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The map label for this gene is mdtA [H]

Identifier: 157961805

GI number: 157961805

Start: 2406610

End: 2407692

Strand: Direct

Name: mdtA [H]

Synonym: Spea_1982

Alternate gene names: 157961805

Gene position: 2406610-2407692 (Clockwise)

Preceding gene: 157961804

Following gene: 157961806

Centisome position: 46.51

GC content: 45.15

Gene sequence:

>1083_bases
ATGAAAAAAATAATAATATTCCTTACTTTGCTTGGTGCCGTCGGCGCCTATTTCTATTTACAACAAGCTCCCAGCGAAAA
AGTGAAAAGAGCGCGGCCGACACCGAATGTGGTGATAACTAAGGCGTCGATGCAAGTTATTCGTGATGAGGTCGAGGCGC
TCGGTACCAGTAAGGCAAATGAATCGATTACCGTCACTCCAAAAGTAACTGAAGTGGTTACCCAAGTGAACTTTAATGAT
GGTGAACTGGTTAAGAAAGGCCGATTACTGGTTCAATTGCAGGATCGTGAGCAGCTTGCTCGTGTAACGGTAGCTAAAGT
AAAAGTAAAAGATCACCAGCGAGAACTTGAGCGAATTCGTACGCTTGTGACGAGTCAAACTATTGCCGAACTTGAGCGCG
ATCGCCTACAAACCCTTATCGACACAGCAAAAGCTGAATTAGTTCAAGCAGAGTCAGCCCTAAAAGATAGAAGGATTACT
GCTCCATTTTCTGGTTCATTGGGCCTACGTCAAGTGAGTATTGGCGCACTAGTAACCCCTGGCAATGCAATCACGACCTT
AGATGATATCTCAGTGATCAAATTGGACTTTTCCGTACCCGAACGCTTCTTACAGGCTCTAGCATTAGGAAAAACCGTCG
AAGCGACCGCTGTGGCATTCGACGGGGAGATATTTAACGGCAAAGTCGTTTCTATCGATAGTCGAATAAATCCAAAGACT
CGCGCAGTTATCGTCAGAGCGGAGATCCCCAATCCAAAGCAAAGATTGCTACCCGGAATGTTGATGAAGGTGAAGTTGAT
CAAAACCAGTAGAGATGCGCTCATCCTCCCTGAATCAGCCATCATTCCAATCCAAGACAGGCATTATGTCTATTTGGTGA
ATGAAGAAGGTGTGATAGAGCAAAAGCAGGTCTCTTTAGGTTTACGCAAACGTGGTTGGGTCGAAATCTTGGATGGCGTA
ATGTTGAATGATCAAATCGTAATTCGTGGTTTATTGAAAGTCCGTCCAGGGGACAAAGTAAAAGTGACCCTAAGTGAGCG
CTTTAGCTTTCTTAAGCAAGCGAGTGTGGAGCCAGTGGCATGA

Upstream 100 bases:

>100_bases
CTTAAGTGTGTCATTTGTAAGAAAAAGTAAAAGCTATTGATGCTAAGTTATCTCAAGGTAAACTAAACACAATTGGATAC
CGTAGTCTGTCAGGGCAATC

Downstream 100 bases:

>100_bases
TCCTAACTGATATTTCGGTTAAGCGACCGGTCTTCGCTTCAGTCATCAGTATTCTGCTCATCATATTTGGCCTAGTAGCC
TTTGAAAAGCTGCCGTTGAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKKIIIFLTLLGAVGAYFYLQQAPSEKVKRARPTPNVVITKASMQVIRDEVEALGTSKANESITVTPKVTEVVTQVNFND
GELVKKGRLLVQLQDREQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELVQAESALKDRRIT
APFSGSLGLRQVSIGALVTPGNAITTLDDISVIKLDFSVPERFLQALALGKTVEATAVAFDGEIFNGKVVSIDSRINPKT
RAVIVRAEIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYLVNEEGVIEQKQVSLGLRKRGWVEILDGV
MLNDQIVIRGLLKVRPGDKVKVTLSERFSFLKQASVEPVA

Sequences:

>Translated_360_residues
MKKIIIFLTLLGAVGAYFYLQQAPSEKVKRARPTPNVVITKASMQVIRDEVEALGTSKANESITVTPKVTEVVTQVNFND
GELVKKGRLLVQLQDREQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELVQAESALKDRRIT
APFSGSLGLRQVSIGALVTPGNAITTLDDISVIKLDFSVPERFLQALALGKTVEATAVAFDGEIFNGKVVSIDSRINPKT
RAVIVRAEIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYLVNEEGVIEQKQVSLGLRKRGWVEILDGV
MLNDQIVIRGLLKVRPGDKVKVTLSERFSFLKQASVEPVA
>Mature_360_residues
MKKIIIFLTLLGAVGAYFYLQQAPSEKVKRARPTPNVVITKASMQVIRDEVEALGTSKANESITVTPKVTEVVTQVNFND
GELVKKGRLLVQLQDREQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELVQAESALKDRRIT
APFSGSLGLRQVSIGALVTPGNAITTLDDISVIKLDFSVPERFLQALALGKTVEATAVAFDGEIFNGKVVSIDSRINPKT
RAVIVRAEIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYLVNEEGVIEQKQVSLGLRKRGWVEILDGV
MLNDQIVIRGLLKVRPGDKVKVTLSERFSFLKQASVEPVA

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=358, Percent_Identity=27.9329608938547, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789665, Length=355, Percent_Identity=27.0422535211268, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789929, Length=383, Percent_Identity=24.5430809399478, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786668, Length=344, Percent_Identity=26.1627906976744, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39909; Mature: 39909

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIIFLTLLGAVGAYFYLQQAPSEKVKRARPTPNVVITKASMQVIRDEVEALGTSKAN
CCCEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCC
ESITVTPKVTEVVTQVNFNDGELVKKGRLLVQLQDREQLARVTVAKVKVKDHQRELERIR
CEEEECCHHHHHHHEECCCCCCEEECCEEEEEECCHHHHHHHHHEEEEEHHHHHHHHHHH
TLVTSQTIAELERDRLQTLIDTAKAELVQAESALKDRRITAPFSGSLGLRQVSIGALVTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEECEEECC
GNAITTLDDISVIKLDFSVPERFLQALALGKTVEATAVAFDGEIFNGKVVSIDSRINPKT
CCCEEEECCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCEEECCEEEEECCCCCCCE
RAVIVRAEIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYLVNEEGVIE
EEEEEEECCCCCHHHHCCHHHEEEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCC
QKQVSLGLRKRGWVEILDGVMLNDQIVIRGLLKVRPGDKVKVTLSERFSFLKQASVEPVA
HHHHHHCCCCCCHHHHHCCEEECCCEEEEEHEECCCCCEEEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKIIIFLTLLGAVGAYFYLQQAPSEKVKRARPTPNVVITKASMQVIRDEVEALGTSKAN
CCCEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCC
ESITVTPKVTEVVTQVNFNDGELVKKGRLLVQLQDREQLARVTVAKVKVKDHQRELERIR
CEEEECCHHHHHHHEECCCCCCEEECCEEEEEECCHHHHHHHHHEEEEEHHHHHHHHHHH
TLVTSQTIAELERDRLQTLIDTAKAELVQAESALKDRRITAPFSGSLGLRQVSIGALVTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEECEEECC
GNAITTLDDISVIKLDFSVPERFLQALALGKTVEATAVAFDGEIFNGKVVSIDSRINPKT
CCCEEEECCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCEEECCEEEEECCCCCCCE
RAVIVRAEIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYLVNEEGVIE
EEEEEEECCCCCHHHHCCHHHEEEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCC
QKQVSLGLRKRGWVEILDGVMLNDQIVIRGLLKVRPGDKVKVTLSERFSFLKQASVEPVA
HHHHHHCCCCCCHHHHHCCEEECCCEEEEEHEECCCCCEEEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]