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The map label for this gene is rotA [H]

Identifier: 157961768

GI number: 157961768

Start: 2365103

End: 2365708

Strand: Reverse

Name: rotA [H]

Synonym: Spea_1945

Alternate gene names: 157961768

Gene position: 2365708-2365103 (Counterclockwise)

Preceding gene: 157961774

Following gene: 157961754

Centisome position: 45.72

GC content: 39.27

Gene sequence:

>606_bases
ATGAATAAAGCAATTCCTCTTCTATTTTGTATGACTTTGGCCGCTTGCGGTGGCAGCGAAACAGATAATGTTGAAATACC
TCAACCTCCTATCCAAGCACCAAATTTACAAGCTGACATTTGTTACCAGATGTCGACGACTATGGGCGATATACTATTAG
CTATCGATCTAACTAACATGCCAATCACGGGTCAAAACTTTAAAAGTTATGCTGATGAAGGCTTCTACACTGGAACCTTA
TTTCATCGCACTATCAATAATTTCGTAATACAGACAGGAGGTTTTACTAGTGGTTTAGTATATAAGCCTGGTAACGAACC
GATAGTTAATGAGGCTGATATAGGGATAAGTAATAAGCGCGGCACCATTGCTATGGCTCGTACGAGTGCAGCTGATTCTG
CAACCACTCAGTTTTTCATTAATGTATTAGATAACCCTCAGCTAGATGCAACAGACGCTAACTATGGCTATGCTGTGTTT
GGCAAGGTATTGCAAGGTATGGATGTAGTGGATCAGATAAGCATCGTTGAAACGGATAGTAATGATGTTCCGAAAACAGA
AATCATTATTAATTCACTTACAGAATCTAGCTGTATGGTCAATTAA

Upstream 100 bases:

>100_bases
TTGCTCCCCTGCCTAGAATCGTTAAAATCAACACTCAACTGCAACACCAGACACATCAGGTTAACAACATTTTAATTGAT
GATATAATTGTGAGAACAAA

Downstream 100 bases:

>100_bases
CAAGCTATAAAATGAGTGTCGTTGCTTACTTTCTATAGCGCGACACTAACATATAAACCCTATCATATTTTCCCACCCTC
TTCGCTTCCTCACTGCAAAC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MNKAIPLLFCMTLAACGGSETDNVEIPQPPIQAPNLQADICYQMSTTMGDILLAIDLTNMPITGQNFKSYADEGFYTGTL
FHRTINNFVIQTGGFTSGLVYKPGNEPIVNEADIGISNKRGTIAMARTSAADSATTQFFINVLDNPQLDATDANYGYAVF
GKVLQGMDVVDQISIVETDSNDVPKTEIIINSLTESSCMVN

Sequences:

>Translated_201_residues
MNKAIPLLFCMTLAACGGSETDNVEIPQPPIQAPNLQADICYQMSTTMGDILLAIDLTNMPITGQNFKSYADEGFYTGTL
FHRTINNFVIQTGGFTSGLVYKPGNEPIVNEADIGISNKRGTIAMARTSAADSATTQFFINVLDNPQLDATDANYGYAVF
GKVLQGMDVVDQISIVETDSNDVPKTEIIINSLTESSCMVN
>Mature_201_residues
MNKAIPLLFCMTLAACGGSETDNVEIPQPPIQAPNLQADICYQMSTTMGDILLAIDLTNMPITGQNFKSYADEGFYTGTL
FHRTINNFVIQTGGFTSGLVYKPGNEPIVNEADIGISNKRGTIAMARTSAADSATTQFFINVLDNPQLDATDANYGYAVF
GKVLQGMDVVDQISIVETDSNDVPKTEIIINSLTESSCMVN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22547215, Length=156, Percent_Identity=33.974358974359, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI22547212, Length=156, Percent_Identity=33.974358974359, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI7657473, Length=156, Percent_Identity=33.974358974359, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4758950, Length=170, Percent_Identity=31.1764705882353, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=33.9622641509434, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=29.1139240506329, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=160, Percent_Identity=50, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=49.0683229813665, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17539496, Length=152, Percent_Identity=32.2368421052632, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506307, Length=171, Percent_Identity=34.5029239766082, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=151, Percent_Identity=36.4238410596026, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17986117, Length=144, Percent_Identity=32.6388888888889, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922376, Length=157, Percent_Identity=29.9363057324841, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21651; Mature: 21651

Theoretical pI: Translated: 3.92; Mature: 3.92

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAIPLLFCMTLAACGGSETDNVEIPQPPIQAPNLQADICYQMSTTMGDILLAIDLTNM
CCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHEEEEHHCCCCEEEEEEEECCC
PITGQNFKSYADEGFYTGTLFHRTINNFVIQTGGFTSGLVYKPGNEPIVNEADIGISNKR
CCCCCCHHHHHCCCCEEHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCC
GTIAMARTSAADSATTQFFINVLDNPQLDATDANYGYAVFGKVLQGMDVVDQISIVETDS
CEEEEEECCCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEEECCC
NDVPKTEIIINSLTESSCMVN
CCCCHHHHEEECCCCCCCCCC
>Mature Secondary Structure
MNKAIPLLFCMTLAACGGSETDNVEIPQPPIQAPNLQADICYQMSTTMGDILLAIDLTNM
CCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHEEEEHHCCCCEEEEEEEECCC
PITGQNFKSYADEGFYTGTLFHRTINNFVIQTGGFTSGLVYKPGNEPIVNEADIGISNKR
CCCCCCHHHHHCCCCEEHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCC
GTIAMARTSAADSATTQFFINVLDNPQLDATDANYGYAVFGKVLQGMDVVDQISIVETDS
CEEEEEECCCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEEECCC
NDVPKTEIIINSLTESSCMVN
CCCCHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]