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The map label for this gene is pepP [H]

Identifier: 157961536

GI number: 157961536

Start: 2078400

End: 2079704

Strand: Reverse

Name: pepP [H]

Synonym: Spea_1711

Alternate gene names: 157961536

Gene position: 2079704-2078400 (Counterclockwise)

Preceding gene: 157961538

Following gene: 157961535

Centisome position: 40.19

GC content: 45.29

Gene sequence:

>1305_bases
ATGTCTAATATCTACCATCAAAGACGCTCCGAACTGCTCGAGCAGTTACCAAATAACAGTTTAGTGCTTATTGCAGGCTA
TCAACAGAAAGTGCGTAGCAAAAATATCAAATACCATTTTAGACAAGATAACGACTTTCTCTACTTAACGGGTTTCGATG
AACCCGATGCCATTGCATTACTTATTAAAGGAGATGTTAACCAGTACATTTTATTTTGTCGGCCAAAAGACCCTGCTCAA
GAGGTTAGCTTTGGTGCGCGAGCGGGAATTGAAGGCGCTGTAGAAATGCACGGTGCTAATAAGGCGTACAGCGTTGCTGA
GTTCGAACACACCCTGCTGCCACTTCTGCAAGGTATTAACACTATCTATGTAAGTGATGAACTGGGGCGCTTCTCGTCGC
AACTCATTAGCTGGGCTAACCATCAACGACATCATTGCTCTTTTGATACACCTAAGCACTTCACCTCGATAAAACCTTTG
GCAGAGCTGTTACACACTAAGCGGGTGATTAAATCCAATGACGAACTCGCTAGAATACGCTCGGCAGTTGCCGCATCCAC
CTTTGGCCATAAGGCGGTCATGCAGGCTTGTAAACCTGGCGTTAATGAACGAGAGCTCTCATCATTATTTGACTTTACTA
TCGCAAAGCATGGCTGTAACGATGTCGCCTACCCTAGTATTGTCGCCGGCGGCAATAACGCCTGTTGTCTGCATTATGAA
GAGAACTGCTGCGAATTATCTGACGGACAGATGCTGCTTATCGATGCTGGCGGTGAATTCAAACATTACGCCGCAGATAT
TACCCGCAGTTACCCGGTTAATGGCCGCTTTACTCCGGAGCAAAAAGCTATCTATCAATTAGTGCTAAATGCGTTAGATC
AAGCCATCGAAAAAGTACGTCCAGGAGCAGCTTGGAATACTCTTTATGAAACATGCATGCAAGTGATGGCTGAGGGGCTT
AAAGAGCTTGGTCTCCTAGAAGGTACTATTGAGGAGATCATGGCAAGTGAGAGTTATAAGCGCTTTACCGTACATAAGAC
TGGCCATTGGTTAGGCATGGATGTTCATGATGTTGGCCCCTATCATGACAATGAAGGTCACTGGCGCACACTCGAAGCTG
ACATGGTGTTTACCATTGAGCCAGGTATTTATTTTCCGAAAGATGCCATAGATATACCAGAAGCGTATCGCGGTATGGGG
ATCCGTATCGAAGATGATATTTTGGTCACCGAAACAGGCTTTGAGAACCTGTCAGTCCATGTACCAAGAACGATAGAAGA
GATTGAAGACTGTATGGGAGCCTAA

Upstream 100 bases:

>100_bases
AACTTGCTATAAAGCAGCTAATAACGTGTAATGAATAAAATATACAGTCTTAAATTTTATAGACTGCAGCAGATTCAATT
AACCGCTATGGAATAATAAG

Downstream 100 bases:

>100_bases
AGCAATCCAGTTCCAGCAATAAAGTTAGAATTAAAGTTAGAGTTAGAGTTAGGTGCAATGAGAGTGACAGTTCATTTTAT
TGCGCTTAGCTCTCCCCCCT

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNIYHQRRSELLEQLPNNSLVLIAGYQQKVRSKNIKYHFRQDNDFLYLTGFDEPDAIALLIKGDVNQYILFCRPKDPAQ
EVSFGARAGIEGAVEMHGANKAYSVAEFEHTLLPLLQGINTIYVSDELGRFSSQLISWANHQRHHCSFDTPKHFTSIKPL
AELLHTKRVIKSNDELARIRSAVAASTFGHKAVMQACKPGVNERELSSLFDFTIAKHGCNDVAYPSIVAGGNNACCLHYE
ENCCELSDGQMLLIDAGGEFKHYAADITRSYPVNGRFTPEQKAIYQLVLNALDQAIEKVRPGAAWNTLYETCMQVMAEGL
KELGLLEGTIEEIMASESYKRFTVHKTGHWLGMDVHDVGPYHDNEGHWRTLEADMVFTIEPGIYFPKDAIDIPEAYRGMG
IRIEDDILVTETGFENLSVHVPRTIEEIEDCMGA

Sequences:

>Translated_434_residues
MSNIYHQRRSELLEQLPNNSLVLIAGYQQKVRSKNIKYHFRQDNDFLYLTGFDEPDAIALLIKGDVNQYILFCRPKDPAQ
EVSFGARAGIEGAVEMHGANKAYSVAEFEHTLLPLLQGINTIYVSDELGRFSSQLISWANHQRHHCSFDTPKHFTSIKPL
AELLHTKRVIKSNDELARIRSAVAASTFGHKAVMQACKPGVNERELSSLFDFTIAKHGCNDVAYPSIVAGGNNACCLHYE
ENCCELSDGQMLLIDAGGEFKHYAADITRSYPVNGRFTPEQKAIYQLVLNALDQAIEKVRPGAAWNTLYETCMQVMAEGL
KELGLLEGTIEEIMASESYKRFTVHKTGHWLGMDVHDVGPYHDNEGHWRTLEADMVFTIEPGIYFPKDAIDIPEAYRGMG
IRIEDDILVTETGFENLSVHVPRTIEEIEDCMGA
>Mature_433_residues
SNIYHQRRSELLEQLPNNSLVLIAGYQQKVRSKNIKYHFRQDNDFLYLTGFDEPDAIALLIKGDVNQYILFCRPKDPAQE
VSFGARAGIEGAVEMHGANKAYSVAEFEHTLLPLLQGINTIYVSDELGRFSSQLISWANHQRHHCSFDTPKHFTSIKPLA
ELLHTKRVIKSNDELARIRSAVAASTFGHKAVMQACKPGVNERELSSLFDFTIAKHGCNDVAYPSIVAGGNNACCLHYEE
NCCELSDGQMLLIDAGGEFKHYAADITRSYPVNGRFTPEQKAIYQLVLNALDQAIEKVRPGAAWNTLYETCMQVMAEGLK
ELGLLEGTIEEIMASESYKRFTVHKTGHWLGMDVHDVGPYHDNEGHWRTLEADMVFTIEPGIYFPKDAIDIPEAYRGMGI
RIEDDILVTETGFENLSVHVPRTIEEIEDCMGA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=408, Percent_Identity=35.5392156862745, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI149589008, Length=482, Percent_Identity=31.1203319502075, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=36.1204013377926, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI260593663, Length=470, Percent_Identity=27.6595744680851, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1789275, Length=435, Percent_Identity=39.3103448275862, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1788728, Length=313, Percent_Identity=26.1980830670927, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1790282, Length=296, Percent_Identity=29.7297297297297, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=472, Percent_Identity=30.7203389830508, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71989583, Length=287, Percent_Identity=31.0104529616725, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=443, Percent_Identity=31.6027088036117, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321118, Length=421, Percent_Identity=29.9287410926366, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19920384, Length=422, Percent_Identity=32.9383886255924, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21357079, Length=455, Percent_Identity=32.967032967033, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48774; Mature: 48643

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIYHQRRSELLEQLPNNSLVLIAGYQQKVRSKNIKYHFRQDNDFLYLTGFDEPDAIAL
CCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEE
LIKGDVNQYILFCRPKDPAQEVSFGARAGIEGAVEMHGANKAYSVAEFEHTLLPLLQGIN
EEECCCCEEEEEECCCCCHHHHCCCHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCC
TIYVSDELGRFSSQLISWANHQRHHCSFDTPKHFTSIKPLAELLHTKRVIKSNDELARIR
EEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SAVAASTFGHKAVMQACKPGVNERELSSLFDFTIAKHGCNDVAYPSIVAGGNNACCLHYE
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEC
ENCCELSDGQMLLIDAGGEFKHYAADITRSYPVNGRFTPEQKAIYQLVLNALDQAIEKVR
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PGAAWNTLYETCMQVMAEGLKELGLLEGTIEEIMASESYKRFTVHKTGHWLGMDVHDVGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCHHCCCC
YHDNEGHWRTLEADMVFTIEPGIYFPKDAIDIPEAYRGMGIRIEDDILVTETGFENLSVH
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCEEEECCEEEEECCCCCEEEE
VPRTIEEIEDCMGA
CCHHHHHHHHHHCC
>Mature Secondary Structure 
SNIYHQRRSELLEQLPNNSLVLIAGYQQKVRSKNIKYHFRQDNDFLYLTGFDEPDAIAL
CCHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEE
LIKGDVNQYILFCRPKDPAQEVSFGARAGIEGAVEMHGANKAYSVAEFEHTLLPLLQGIN
EEECCCCEEEEEECCCCCHHHHCCCHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCC
TIYVSDELGRFSSQLISWANHQRHHCSFDTPKHFTSIKPLAELLHTKRVIKSNDELARIR
EEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SAVAASTFGHKAVMQACKPGVNERELSSLFDFTIAKHGCNDVAYPSIVAGGNNACCLHYE
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEC
ENCCELSDGQMLLIDAGGEFKHYAADITRSYPVNGRFTPEQKAIYQLVLNALDQAIEKVR
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PGAAWNTLYETCMQVMAEGLKELGLLEGTIEEIMASESYKRFTVHKTGHWLGMDVHDVGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCHHCCCC
YHDNEGHWRTLEADMVFTIEPGIYFPKDAIDIPEAYRGMGIRIEDDILVTETGFENLSVH
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCEEEECCEEEEECCCCCEEEE
VPRTIEEIEDCMGA
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]