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The map label for this gene is fabB [H]

Identifier: 157961432

GI number: 157961432

Start: 1945794

End: 1947068

Strand: Direct

Name: fabB [H]

Synonym: Spea_1606

Alternate gene names: 157961432

Gene position: 1945794-1947068 (Clockwise)

Preceding gene: 157961430

Following gene: 157961433

Centisome position: 37.6

GC content: 45.88

Gene sequence:

>1275_bases
ATGAAAAGCGATACCATTGGTGCAGCAAAATTGGTACTAGATGTACAAAATGGAAAGTTAATAATGAAAAGAGTCGTGAT
CACTGGACTTGGTGTCGTATCAAGTATCGGTAACAACAAGCAAGAAGTCACTGAATCATTAAAAGCGGGTCGTAGTGGTA
TTACCCACTCTGATCAGTTTGAAGAAATGAAGCTGCGTAGTCATGTTTGGGGCGACATTAAGATTGACCCATCAGAATAT
ATTGACCGTAAAGCACTGCGCTTTATGGGTAATGCAGCAGCTTACGCACATATCGCAATGCAAGAAGCGATTAAAGATGC
AGGTTTAGTTGAAGAGCAGTATTCAGACCCTCGTGTCGGTATTATCGTAGGCTCGGGCGGCGCATCTTCAGCAAATCAGG
TTCAAGCTGCTGACACGTTACGTGAAAAAGGCGTTAAGCGCGTTGGTCCATATATTGTGCCGCGTATTATGTCGAGCACA
GCAAGCGCATGTTTGGCTACGCCATTTAAGATTAAAGGCATGAACTACTCAATCAGTTCTGCTTGTGCAACTAGCGCACA
CTGTATCGGCCACGCGGCTGAACTTATCCAGATGGGTAAGCAAGATATGGTATTTGCTGGTGGTGCAGAAGAAGTGGATT
GGACGCTTACCATGGGCTTCGATGCTATGGGCGCACTATCGACTAAGTTTAATGATGATCCCACTAAAGCATCTCGTACC
TATGATGCAGACCGTGATGGTTTTGTTATCTCTGGTGGCGGCGGAATCGTGGTTGTTGAAGAGCTAGAACACGCTCTTGC
ACGTGGCGCAAAAATCTACGCTGAGATCATCGGTTATGGCGCATCATCAGACGGCTATGACATGGTTGCTCCATCAGGTG
AAGGTGCGGTTCGCTGTATGCAGATGGCTCTTGCCGATGTAGACACACCAATCGATTACATCAATACTCACGGTACATCA
ACACCTGTGGGTGATATGCGTGAGCTTGAAGCACTACGTGAAACCTTTGGTGATAACCTACCAGCTATCGCATCGACTAA
GTCTCTAACGGGTCATGCACTGGGCGCGGCGGGTGCACACGAAGCGATTTATAGCTTGATCATGATGGAAAGTAGTTTCA
TCGCACCAAGCATCAACATTGATACTGTCGATGAAAAAGCCGAAGGCATGCCAATTGTGACTAAAATGACTGAAAAAGAG
CTCAATACTGTGATGAGCAACAGTTTTGGTTTTGGTGGCACAAACGCAACTTTGGTTATGCGTAAGTACAAGTAA

Upstream 100 bases:

>100_bases
TTGTACATTTTTATGGGCATATTTTGGCAAAGATTATACGTAAGGTCTCATAATGAGCATTATTTTTGTGTTCCTTATGG
AAAGCTGACCACTTAAATGG

Downstream 100 bases:

>100_bases
ACTGTACTTATACTCAGCAAAGATAGATTGAAAAGGAAGCCTAGGCTTCCTTTTTTTGTGTCTTGTTTTGCTGTCCAGCC
CCAATTGACAGGATCCCTTC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKSDTIGAAKLVLDVQNGKLIMKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSDQFEEMKLRSHVWGDIKIDPSEY
IDRKALRFMGNAAAYAHIAMQEAIKDAGLVEEQYSDPRVGIIVGSGGASSANQVQAADTLREKGVKRVGPYIVPRIMSST
ASACLATPFKIKGMNYSISSACATSAHCIGHAAELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKFNDDPTKASRT
YDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDYINTHGTS
TPVGDMRELEALRETFGDNLPAIASTKSLTGHALGAAGAHEAIYSLIMMESSFIAPSINIDTVDEKAEGMPIVTKMTEKE
LNTVMSNSFGFGGTNATLVMRKYK

Sequences:

>Translated_424_residues
MKSDTIGAAKLVLDVQNGKLIMKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSDQFEEMKLRSHVWGDIKIDPSEY
IDRKALRFMGNAAAYAHIAMQEAIKDAGLVEEQYSDPRVGIIVGSGGASSANQVQAADTLREKGVKRVGPYIVPRIMSST
ASACLATPFKIKGMNYSISSACATSAHCIGHAAELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKFNDDPTKASRT
YDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDYINTHGTS
TPVGDMRELEALRETFGDNLPAIASTKSLTGHALGAAGAHEAIYSLIMMESSFIAPSINIDTVDEKAEGMPIVTKMTEKE
LNTVMSNSFGFGGTNATLVMRKYK
>Mature_424_residues
MKSDTIGAAKLVLDVQNGKLIMKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSDQFEEMKLRSHVWGDIKIDPSEY
IDRKALRFMGNAAAYAHIAMQEAIKDAGLVEEQYSDPRVGIIVGSGGASSANQVQAADTLREKGVKRVGPYIVPRIMSST
ASACLATPFKIKGMNYSISSACATSAHCIGHAAELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKFNDDPTKASRT
YDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDYINTHGTS
TPVGDMRELEALRETFGDNLPAIASTKSLTGHALGAAGAHEAIYSLIMMESSFIAPSINIDTVDEKAEGMPIVTKMTEKE
LNTVMSNSFGFGGTNATLVMRKYK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=35.5608591885441, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=42.7536231884058, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=25.5269320843091, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=69.1358024691358, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=39.1727493917275, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=34.4497607655502, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=38.4905660377359, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=330, Percent_Identity=27.8787878787879, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=26.4788732394366, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=31.4159292035398, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=37.6190476190476, Blast_Score=258, Evalue=8e-69,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=26.1904761904762, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=26.1904761904762, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581345, Length=339, Percent_Identity=24.188790560472, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 45019; Mature: 45019

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDTIGAAKLVLDVQNGKLIMKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSDQF
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHH
EEMKLRSHVWGDIKIDPSEYIDRKALRFMGNAAAYAHIAMQEAIKDAGLVEEQYSDPRVG
HHHHHHHHCCCCEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEE
IIVGSGGASSANQVQAADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISS
EEEECCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHH
ACATSAHCIGHAAELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKFNDDPTKASRT
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCC
YDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIIGYGASSDGYDMVAPSGEGAVRCM
CCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHH
QMALADVDTPIDYINTHGTSTPVGDMRELEALRETFGDNLPAIASTKSLTGHALGAAGAH
HHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
EAIYSLIMMESSFIAPSINIDTVDEKAEGMPIVTKMTEKELNTVMSNSFGFGGTNATLVM
HHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCEEEEE
RKYK
EECC
>Mature Secondary Structure
MKSDTIGAAKLVLDVQNGKLIMKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSDQF
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHH
EEMKLRSHVWGDIKIDPSEYIDRKALRFMGNAAAYAHIAMQEAIKDAGLVEEQYSDPRVG
HHHHHHHHCCCCEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEE
IIVGSGGASSANQVQAADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISS
EEEECCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHH
ACATSAHCIGHAAELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKFNDDPTKASRT
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCC
YDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIIGYGASSDGYDMVAPSGEGAVRCM
CCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHH
QMALADVDTPIDYINTHGTSTPVGDMRELEALRETFGDNLPAIASTKSLTGHALGAAGAH
HHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
EAIYSLIMMESSFIAPSINIDTVDEKAEGMPIVTKMTEKELNTVMSNSFGFGGTNATLVM
HHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCEEEEE
RKYK
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]