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The map label for this gene is apt [H]

Identifier: 157961333

GI number: 157961333

Start: 1826790

End: 1827341

Strand: Direct

Name: apt [H]

Synonym: Spea_1507

Alternate gene names: 157961333

Gene position: 1826790-1827341 (Clockwise)

Preceding gene: 157961332

Following gene: 157961334

Centisome position: 35.3

GC content: 41.49

Gene sequence:

>552_bases
ATGGTAATGAATACTGACAGCTTGGCACTAATAAAGAACAGCATTAAAACCATCCCTAATTATCCTAAAGAAGGGATCCT
GTTTAGAGATGTGACTAGCTTATTAGAAGATCCACAAGCCTATAAACTCACCATTGGCCTTTTAGTTGAGCACTATAAAG
ACCAAGGGTTTACTAAGGTTGTCGGTACTGAAGCGCGCGGCTTTTTGTTTGGCGCACCTTTAGCCCTTGAGCTAGGCATA
GGCTTTGTACCTGTTCGTAAGCCTGGTAAATTACCAAGAGAAACGATTTCAGAAAGCTATGAGCTTGAATATGGTCATGA
TGTATTAGAGATCCATGTTGATGCGATCAATGCTGACGACAAAGTACTGGTAATCGATGACTTACTTGCAACTGGCGGTA
CAATCGAAGCGACTGTTAAGCTTATCCGTAAATTAGGCGGAAGCGTAAACGATGCCGCTTTTGTTATTTCATTACCTGAC
TTAGGTGGTGAAGAGCGTCTAAAAGCGATGGATCTTAAGCTAATCAGTCTTTGTGAGTTTGAAGGCGAATAA

Upstream 100 bases:

>100_bases
GCTTGATGCCGATTTTTACACTTCGATGACATCTATACCGGCATAATCAAATTTTGGGGCTGGGGATGTCAGCAAACTAA
AGTAGATTAAGTAAAGAATT

Downstream 100 bases:

>100_bases
GTCTATAGGCTGCTGCGATAAACAGTAGCAATAAGGAGTTGGCAAAACTGTCGATTCTTTATCTTAAAAGGTGAATTAAT
CACCGCCAAATCGCTCCTAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINADDKVLVIDDLLATGGTIEATVKLIRKLGGSVNDAAFVISLPD
LGGEERLKAMDLKLISLCEFEGE

Sequences:

>Translated_183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINADDKVLVIDDLLATGGTIEATVKLIRKLGGSVNDAAFVISLPD
LGGEERLKAMDLKLISLCEFEGE
>Mature_183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINADDKVLVIDDLLATGGTIEATVKLIRKLGGSVNDAAFVISLPD
LGGEERLKAMDLKLISLCEFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=182, Percent_Identity=40.6593406593407, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=45.1127819548872, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=72.1311475409836, Blast_Score=261, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=42.7745664739884, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=40.5882352941176, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=39.0243902439024, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136334, Length=177, Percent_Identity=45.1977401129944, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19986; Mature: 19986

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINADD
ECCCCCCEEEECCEEEEECCCEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEEEEECCCC
KVLVIDDLLATGGTIEATVKLIRKLGGSVNDAAFVISLPDLGGEERLKAMDLKLISLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
EGE
CCC
>Mature Secondary Structure
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINADD
ECCCCCCEEEECCEEEEECCCEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEEEEECCCC
KVLVIDDLLATGGTIEATVKLIRKLGGSVNDAAFVISLPDLGGEERLKAMDLKLISLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
EGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA