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The map label for this gene is tyrR [H]

Identifier: 157961276

GI number: 157961276

Start: 1763886

End: 1765427

Strand: Direct

Name: tyrR [H]

Synonym: Spea_1450

Alternate gene names: 157961276

Gene position: 1763886-1765427 (Clockwise)

Preceding gene: 157961275

Following gene: 157961277

Centisome position: 34.09

GC content: 45.46

Gene sequence:

>1542_bases
ATGCGCTTGGAAGTCAGCTGTTTAGACCGAGTGGGTCTCGCCAAAGATATCTTATTGATTATGGAAGACTATGGGATTAA
TTTGTTTGCTATTGACGCAAGCAACCAAGGTTTTCTTTATCTACAATTTGCTGAAGTGAGTTTCGATACTCTCAGTGAAT
TGCTCCCCCTTATACGAAAAGTAGAAGGCGTACATGATGTGCGGACGGTGTCATTTATGCCGTCTGAGCAGGAACACTAC
GCACTAAAAACGCTTTTAAAAACCTTACCAGACTCTGTGTTCTCACTCGATGTGAAAGGACGGATCCGCATCGTTAATGA
ATCGGCCTTACACACAGTCGGTATGGCCGAACATGAAGTGATAGATGAGCCTATAAATCATTGGGTGCAGGGATTCAGCT
TTAGCCGTTGGTTAAGCGAATCAACCGTACTGGCTCAAGCGACACGGGTGAATATCGGAGAGAATGAATACTTAGCCGAG
ATGTTACCTATTTATTTACCCGATAGTGGTAGTGAGACGCCCATTTTAGCGGGTGCAGTGGTATCGCTAAAATCGCCAGC
ACGTTTAGGTAAACAATTTAACGCCCTGCAAAATCAATCTAGTGGCTTTGAGAATGTGCTTGCAACCAGTGACAAGATGA
AAGAGGTCCTCGTTCAGGCTCGCCGTATGGCACAGCTCGATGCGCCTTTGTTGATTACGGGTGAAACGGGGACGGGAAAA
GAGCTAATGTCTCGTGCTTGCCATGATGCCAGTATGCGCCGTGAACATCCTTTTATCGCAATTAACTGTGCAGCTATGCC
AGACAGTGCTGCCGAAGAAGAGCTTTTTGGTTTTGTTAGTAATGGCAACGTGGCCAAGCGTGGCTTTATTGAGGAAGCTA
AGGGCGGAACGATTTTTCTTGATGAGATAGCCGAGATGTCAAAGTCTGCTCAGGTCAAGTTGTTACGATTCATACAAGAC
GGTACCTTTAGACGGGTAGGGGGCGATGAGGAGATCCGCAGTGACGTGCGTATTATCTGCTCGACGCAGAAGAATCTTGC
CGAGCTATGCCAAAATGGCGAGTTTAGAGAAGATCTTTATTACCGTATCCATGTATTGAGTTTTCATGTGCCTTCCTTGC
GTGAACGTAAAGTGGATATCATTCCGCTGACAGAAATGTTTTTAGAGCATTACAGCCAGCAACTATCAATCCCTATTCGC
CGCATATCAGGTGAGTGTCGCGAGCACCTGTTAGCTTATGCATGGCCAGGCAATGTACGTCAGCTTAAAAATGCTATCTT
TAGAGCCGTATCTATGTGGGATGGAAGTGCAGAACTCACGGTTGAACAACTAAAGTTACCCTCATACGCCGAAGGTTTTG
GCTATTTCGATCATCAGTTCGAAGGCAGTCTTGAGCAAGCGATGAAACAGTTTGAAGCGAGTCTCTTACGAAGATTGTAT
CCGGCTTACCCAAGTACTCGACAACTAGCTAAGAAGTTAGGTGTATCTCATACCGCAATCGCTAACAAACTACGAGAATA
TAAGATCAACAAACCCAAGTAG

Upstream 100 bases:

>100_bases
GTGGATGTTGCTTTTAAGCTGCCCCCTAAACCGTGCGAATTCCCTTCTGATGGTTGTTTTATCCCAATAACGAGTATTTA
GAAAAGGGAATTGCAATAGT

Downstream 100 bases:

>100_bases
CTGTAAATGAGGTTTGCCGTCGATTGCTGTTTAGATAGGCAGCTTTCGACCTAAACTATTACTTTTAGCCTATTATTTAT
GGGGTGTATCTATAAGTTTA

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDTLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSLDVKGRIRIVNESALHTVGMAEHEVIDEPINHWVQGFSFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVAKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQNGEFREDLYYRIHVLSFHVPSLRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLAYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEQAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKINKPK

Sequences:

>Translated_513_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDTLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSLDVKGRIRIVNESALHTVGMAEHEVIDEPINHWVQGFSFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVAKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQNGEFREDLYYRIHVLSFHVPSLRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLAYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEQAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKINKPK
>Mature_513_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDTLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSLDVKGRIRIVNESALHTVGMAEHEVIDEPINHWVQGFSFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVAKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQNGEFREDLYYRIHVLSFHVPSLRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLAYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEQAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKINKPK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=515, Percent_Identity=47.378640776699, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788550, Length=314, Percent_Identity=37.2611464968153, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1788905, Length=278, Percent_Identity=40.2877697841727, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789233, Length=470, Percent_Identity=30.8510638297872, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082117, Length=324, Percent_Identity=34.8765432098765, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790299, Length=244, Percent_Identity=40.1639344262295, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=36.1370716510903, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1790437, Length=259, Percent_Identity=38.2239382239382, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082152, Length=248, Percent_Identity=42.3387096774194, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786524, Length=270, Percent_Identity=40.3703703703704, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=40.5172413793103, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789828, Length=321, Percent_Identity=29.2834890965732, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI87081858, Length=367, Percent_Identity=27.7929155313352, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57786; Mature: 57786

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDTLSELLPLIRK
CEEEHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VEGVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSLDVKGRIRIVNESALHTVGMAEHEV
HCCHHHHEEEEECCCCHHHHHHHHHHHHCCHHHEEEECCCEEEEEECHHHHHHCCHHHHH
IDEPINHWVQGFSFSRWLSESTVLAQATRVNIGENEYLAEMLPIYLPDSGSETPILAGAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHCCEEECCCCCCCCEEEHHH
VSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
HHCCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVAKRGFIEEAKGGTIFL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEECCCCCCHHCCCHHHCCCCEEEH
DEIAEMSKSAQVKLLRFIQDGTFRRVGGDEEIRSDVRIICSTQKNLAELCQNGEFREDLY
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCHHEEECCHHHHHHHHHCCCCCHHHH
YRIHVLSFHVPSLRERKVDIIPLTEMFLEHYSQQLSIPIRRISGECREHLLAYAWPGNVR
EEEEEEEECCCCHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCHH
QLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEQAMKQFEASLLRRLY
HHHHHHHHHHHHCCCCCCEEHHHHCCCCHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHC
PAYPSTRQLAKKLGVSHTAIANKLREYKINKPK
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDTLSELLPLIRK
CEEEHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VEGVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSLDVKGRIRIVNESALHTVGMAEHEV
HCCHHHHEEEEECCCCHHHHHHHHHHHHCCHHHEEEECCCEEEEEECHHHHHHCCHHHHH
IDEPINHWVQGFSFSRWLSESTVLAQATRVNIGENEYLAEMLPIYLPDSGSETPILAGAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHCCEEECCCCCCCCEEEHHH
VSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
HHCCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVAKRGFIEEAKGGTIFL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEECCCCCCHHCCCHHHCCCCEEEH
DEIAEMSKSAQVKLLRFIQDGTFRRVGGDEEIRSDVRIICSTQKNLAELCQNGEFREDLY
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCHHEEECCHHHHHHHHHCCCCCHHHH
YRIHVLSFHVPSLRERKVDIIPLTEMFLEHYSQQLSIPIRRISGECREHLLAYAWPGNVR
EEEEEEEECCCCHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCHH
QLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEQAMKQFEASLLRRLY
HHHHHHHHHHHHCCCCCCEEHHHHCCCCHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHC
PAYPSTRQLAKKLGVSHTAIANKLREYKINKPK
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]