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The map label for this gene is fadE [H]

Identifier: 157961062

GI number: 157961062

Start: 1502313

End: 1504550

Strand: Reverse

Name: fadE [H]

Synonym: Spea_1234

Alternate gene names: 157961062

Gene position: 1504550-1502313 (Counterclockwise)

Preceding gene: 157961063

Following gene: 157961061

Centisome position: 29.08

GC content: 47.59

Gene sequence:

>2238_bases
ATGAGCATAAGAACACAACTAAAAAAAATATTGCCAAGCATTTCTACCACAGAACAAGAGGCACTCGATGCCGGTGATGT
GTGGTTAGAAGGTTCGATTTATCAAGGTGTACCTGACTTTGCAGCCCTACGTGATATCCCCGTTGCTACTCTGTCTAGCG
ACGAGCAGGCATTCCTAGACGGTCCAGTGGCGACCTTACTAGAGATGGTGGATGACTTTGAGATCCAGCGCAGCACACAC
CTCCCTGAAAATATTCTTAACTTCCTAAAAGAAAATAAATTTTTCTCGCTTATTATTCCCAAATCATTCGGTGGCCTCGA
GTTTAGTCCCTACGCAAACTCGACTATCGTTGCCACTATTGCCGCTAAAAGTTCGGCGGTTGCGGTCACTGTAATGGTGC
CAAACTCACTCGGTCCCGGTGAGTTGTTAATGCACTACGGCACCTCTGAGCAACAAGATTACTGGTTACCTCGCCTCGCT
AACGGCCAAGAAATTCCTTGTTTTGCACTAACTAGCCCTGAGGCAGGTTCAGACGCTGGCGGTATTCCGGATATCGGTAC
AGTCACAATGGGCGAATACCAAGGTGAAAAAGTACTTGGCTTAAGCGTAACTTGGGATAAGCGTTATATCACCCTTGCCC
CCATCGCCAGTGTATTAGGCTTGGCCTTTAAGGTAGAAGATCCAAAGGGTCTACTTGGTGGCAAAGAAAATCTTGGTATC
ACCTGCGCGCTTATTCCTAGGTCGCACCCAGGTGTGCAGCTAGGTAATCGTCATGACCCTATGGGGGTTCGCTTTTACAA
CGGTACTACCCGTGGTGAAAACGTGTTTATTCCAATGGACTTCATCATAGGTGGCCAGAAAAACATCGGCCGCGGCTGGG
CAATGCTCGTTGCCTGTCTCGGTGCTGGACGCGGCATTTCACTGCCAGCACTCGGTGTATCAGTGAGTCAGGCGTCATTT
AAATCTTCAGCTGAATATGCAGCAGTGCGTGAGCAGTTTGGCCTATCGATTGGTAAGTTTGAGGGTATTCAAGAGAAGCT
TGCCGATATCGCCGGTAAAACCTATCTGCAAGAAGCGATGCGCGTGCTAACAACTGAAGGCCTAGGCCTTGGGTTAAAGC
CATCGGTTGTGACAGCCATCGCTAAGTATCATATGACAGAGCTTGGCCGTGATATCCTCGACTCGGCAATGGATATTCAG
GCAGGTAAAGCGATTCAGTGTGGCCCGCAAAACACCTTAGCCTCTGGCTATGTGGCCCAACCGATTGCGATTACCGTAGA
AGGCGCCAACATTCTCACCCGTAACCTGATGATTTTCGGTCAAGGTGTGATGCGTTGTCACCCATACTTGCAGTCTATGG
TGGAATCTATCCACTCAAACGAGAAAAGTGCTGACAAAGTCTTTAACGGTATTTTACGTAAAACAGTTAGCTACAGTGTT
GGCAACAGCTTACGTGCCTTTAAGCTAGGTTTATTACCTTTTACCGCATCAGCAGCCTCAACTCTTGCTGAAGTGAAGCC
CTATGAGCAATCAGTACATAAGCTAGCCTCTAAGCTAGCGGTATATGCAGACTTCTCGTTATTAGTTTTAGGTGGCAAGC
TCAAGCAAGCAGAAATGCTGTCAGCCCGCCTAGGTGATGTGATGAGCTACTTGTACGCCGCCATGGCCTCGATTCGTTAC
TATGAAAAGAAATTAACTGCTGCAGAGCAAAAAGAAGCGGCGCCCTATTTCCATTACGCTACGCGCTGGTCACTGTGTCA
GGCAGAGAAAGCCTTGTTGGATTTCTTAGATAACTTCCCTTCATCGGCAACGCGTAAGTTTATGCGTTTAGTCACTGTGA
CTTACTCGGCTAAGATGCCAAAAATCAATGATAATTTAGTTCGTGAATTAGCAGAGCAGGCTCAGCTTAATACCGAGTTC
AAGAAGAACCTGACTCATCTTATTAAGCCTGTGGCAGGTGACGGTAACGACATTAACGAGCAAGCTTACCTTGCGAAGAT
GGTCTGCTTACCACTACTTGCCAAGGTCAAAAAGGCGATTCGCGCCAAGACGTTTAAGCCAGGAGTCAGATTCGCACTGA
CCTTAGATGCCGCGCTTGAGGCTAAGGTGATCACCAGCGACGAGCACAAGCTTTTGCAAGATTACAACCTTAAGCGTGAG
CGTGCTATTCGAGTCGATGAGTTTGACTTTGATATGAACCTTATCGATAACAAGCCCGAGTTGAAGATCGCTAACTAA

Upstream 100 bases:

>100_bases
AATCCAAACGCACGTTTAAATTTATCGTTTGAAAATTTGATCTATGCCTCGTTTTATGACGTAATGTGAAGCATAACTTC
TGGTCGGACGAGCATTTAAT

Downstream 100 bases:

>100_bases
TTGCTAATTCTGTCGTAACTGGCCATGAAGCAGTAATAGACAGTCACTAAAAAGCCACCGCAAGGTGGTTTTTTTAGCTT
CGAAATAAGCTAATTGTATT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MSIRTQLKKILPSISTTEQEALDAGDVWLEGSIYQGVPDFAALRDIPVATLSSDEQAFLDGPVATLLEMVDDFEIQRSTH
LPENILNFLKENKFFSLIIPKSFGGLEFSPYANSTIVATIAAKSSAVAVTVMVPNSLGPGELLMHYGTSEQQDYWLPRLA
NGQEIPCFALTSPEAGSDAGGIPDIGTVTMGEYQGEKVLGLSVTWDKRYITLAPIASVLGLAFKVEDPKGLLGGKENLGI
TCALIPRSHPGVQLGNRHDPMGVRFYNGTTRGENVFIPMDFIIGGQKNIGRGWAMLVACLGAGRGISLPALGVSVSQASF
KSSAEYAAVREQFGLSIGKFEGIQEKLADIAGKTYLQEAMRVLTTEGLGLGLKPSVVTAIAKYHMTELGRDILDSAMDIQ
AGKAIQCGPQNTLASGYVAQPIAITVEGANILTRNLMIFGQGVMRCHPYLQSMVESIHSNEKSADKVFNGILRKTVSYSV
GNSLRAFKLGLLPFTASAASTLAEVKPYEQSVHKLASKLAVYADFSLLVLGGKLKQAEMLSARLGDVMSYLYAAMASIRY
YEKKLTAAEQKEAAPYFHYATRWSLCQAEKALLDFLDNFPSSATRKFMRLVTVTYSAKMPKINDNLVRELAEQAQLNTEF
KKNLTHLIKPVAGDGNDINEQAYLAKMVCLPLLAKVKKAIRAKTFKPGVRFALTLDAALEAKVITSDEHKLLQDYNLKRE
RAIRVDEFDFDMNLIDNKPELKIAN

Sequences:

>Translated_745_residues
MSIRTQLKKILPSISTTEQEALDAGDVWLEGSIYQGVPDFAALRDIPVATLSSDEQAFLDGPVATLLEMVDDFEIQRSTH
LPENILNFLKENKFFSLIIPKSFGGLEFSPYANSTIVATIAAKSSAVAVTVMVPNSLGPGELLMHYGTSEQQDYWLPRLA
NGQEIPCFALTSPEAGSDAGGIPDIGTVTMGEYQGEKVLGLSVTWDKRYITLAPIASVLGLAFKVEDPKGLLGGKENLGI
TCALIPRSHPGVQLGNRHDPMGVRFYNGTTRGENVFIPMDFIIGGQKNIGRGWAMLVACLGAGRGISLPALGVSVSQASF
KSSAEYAAVREQFGLSIGKFEGIQEKLADIAGKTYLQEAMRVLTTEGLGLGLKPSVVTAIAKYHMTELGRDILDSAMDIQ
AGKAIQCGPQNTLASGYVAQPIAITVEGANILTRNLMIFGQGVMRCHPYLQSMVESIHSNEKSADKVFNGILRKTVSYSV
GNSLRAFKLGLLPFTASAASTLAEVKPYEQSVHKLASKLAVYADFSLLVLGGKLKQAEMLSARLGDVMSYLYAAMASIRY
YEKKLTAAEQKEAAPYFHYATRWSLCQAEKALLDFLDNFPSSATRKFMRLVTVTYSAKMPKINDNLVRELAEQAQLNTEF
KKNLTHLIKPVAGDGNDINEQAYLAKMVCLPLLAKVKKAIRAKTFKPGVRFALTLDAALEAKVITSDEHKLLQDYNLKRE
RAIRVDEFDFDMNLIDNKPELKIAN
>Mature_744_residues
SIRTQLKKILPSISTTEQEALDAGDVWLEGSIYQGVPDFAALRDIPVATLSSDEQAFLDGPVATLLEMVDDFEIQRSTHL
PENILNFLKENKFFSLIIPKSFGGLEFSPYANSTIVATIAAKSSAVAVTVMVPNSLGPGELLMHYGTSEQQDYWLPRLAN
GQEIPCFALTSPEAGSDAGGIPDIGTVTMGEYQGEKVLGLSVTWDKRYITLAPIASVLGLAFKVEDPKGLLGGKENLGIT
CALIPRSHPGVQLGNRHDPMGVRFYNGTTRGENVFIPMDFIIGGQKNIGRGWAMLVACLGAGRGISLPALGVSVSQASFK
SSAEYAAVREQFGLSIGKFEGIQEKLADIAGKTYLQEAMRVLTTEGLGLGLKPSVVTAIAKYHMTELGRDILDSAMDIQA
GKAIQCGPQNTLASGYVAQPIAITVEGANILTRNLMIFGQGVMRCHPYLQSMVESIHSNEKSADKVFNGILRKTVSYSVG
NSLRAFKLGLLPFTASAASTLAEVKPYEQSVHKLASKLAVYADFSLLVLGGKLKQAEMLSARLGDVMSYLYAAMASIRYY
EKKLTAAEQKEAAPYFHYATRWSLCQAEKALLDFLDNFPSSATRKFMRLVTVTYSAKMPKINDNLVRELAEQAQLNTEFK
KNLTHLIKPVAGDGNDINEQAYLAKMVCLPLLAKVKKAIRAKTFKPGVRFALTLDAALEAKVITSDEHKLLQDYNLKRER
AIRVDEFDFDMNLIDNKPELKIAN

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=369, Percent_Identity=30.8943089430894, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4557233, Length=317, Percent_Identity=30.5993690851735, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4557235, Length=400, Percent_Identity=24.5, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI76496475, Length=400, Percent_Identity=24.5, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=25.5434782608696, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI226958412, Length=284, Percent_Identity=26.4084507042254, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI226958414, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI87081702, Length=726, Percent_Identity=45.8677685950413, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=340, Percent_Identity=27.0588235294118, Blast_Score=103, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17506239, Length=360, Percent_Identity=26.9444444444444, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71985184, Length=357, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32563615, Length=248, Percent_Identity=28.2258064516129, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=327, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71990804, Length=290, Percent_Identity=25.5172413793103, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=277, Percent_Identity=26.3537906137184, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=304, Percent_Identity=25.9868421052632, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=281, Percent_Identity=25.6227758007117, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=334, Percent_Identity=23.9520958083832, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363737, Length=472, Percent_Identity=25.8474576271186, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356377, Length=291, Percent_Identity=28.8659793814433, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24666513, Length=366, Percent_Identity=25.9562841530055, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646207, Length=317, Percent_Identity=27.4447949526814, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24660351, Length=333, Percent_Identity=24.6246246246246, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355753, Length=310, Percent_Identity=27.4193548387097, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920834, Length=255, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 81208; Mature: 81077

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRTQLKKILPSISTTEQEALDAGDVWLEGSIYQGVPDFAALRDIPVATLSSDEQAFLD
CCHHHHHHHHCCCCCCCHHHHCCCCCEEECCCHHCCCCCHHHHHCCCEEECCCCCHHHHC
GPVATLLEMVDDFEIQRSTHLPENILNFLKENKFFSLIIPKSFGGLEFSPYANSTIVATI
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCEEEEEE
AAKSSAVAVTVMVPNSLGPGELLMHYGTSEQQDYWLPRLANGQEIPCFALTSPEAGSDAG
EECCCEEEEEEEECCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
GIPDIGTVTMGEYQGEKVLGLSVTWDKRYITLAPIASVLGLAFKVEDPKGLLGGKENLGI
CCCCCCEEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHEEEEECCCCCCCCCCCCCCE
TCALIPRSHPGVQLGNRHDPMGVRFYNGTTRGENVFIPMDFIIGGQKNIGRGWAMLVACL
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEHEEECCCCCCCHHHHHHHHHH
GAGRGISLPALGVSVSQASFKSSAEYAAVREQFGLSIGKFEGIQEKLADIAGKTYLQEAM
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RVLTTEGLGLGLKPSVVTAIAKYHMTELGRDILDSAMDIQAGKAIQCGPQNTLASGYVAQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEC
PIAITVEGANILTRNLMIFGQGVMRCHPYLQSMVESIHSNEKSADKVFNGILRKTVSYSV
CEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GNSLRAFKLGLLPFTASAASTLAEVKPYEQSVHKLASKLAVYADFSLLVLGGKLKQAEML
CCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
SARLGDVMSYLYAAMASIRYYEKKLTAAEQKEAAPYFHYATRWSLCQAEKALLDFLDNFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSATRKFMRLVTVTYSAKMPKINDNLVRELAEQAQLNTEFKKNLTHLIKPVAGDGNDINE
CHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCH
QAYLAKMVCLPLLAKVKKAIRAKTFKPGVRFALTLDAALEAKVITSDEHKLLQDYNLKRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHEEEEEECCHHHHHHHCCCCHH
RAIRVDEFDFDMNLIDNKPELKIAN
HCCEEECCCCCCEECCCCCCEEECC
>Mature Secondary Structure 
SIRTQLKKILPSISTTEQEALDAGDVWLEGSIYQGVPDFAALRDIPVATLSSDEQAFLD
CHHHHHHHHCCCCCCCHHHHCCCCCEEECCCHHCCCCCHHHHHCCCEEECCCCCHHHHC
GPVATLLEMVDDFEIQRSTHLPENILNFLKENKFFSLIIPKSFGGLEFSPYANSTIVATI
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCEEEEEE
AAKSSAVAVTVMVPNSLGPGELLMHYGTSEQQDYWLPRLANGQEIPCFALTSPEAGSDAG
EECCCEEEEEEEECCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
GIPDIGTVTMGEYQGEKVLGLSVTWDKRYITLAPIASVLGLAFKVEDPKGLLGGKENLGI
CCCCCCEEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHEEEEECCCCCCCCCCCCCCE
TCALIPRSHPGVQLGNRHDPMGVRFYNGTTRGENVFIPMDFIIGGQKNIGRGWAMLVACL
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEHEEECCCCCCCHHHHHHHHHH
GAGRGISLPALGVSVSQASFKSSAEYAAVREQFGLSIGKFEGIQEKLADIAGKTYLQEAM
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RVLTTEGLGLGLKPSVVTAIAKYHMTELGRDILDSAMDIQAGKAIQCGPQNTLASGYVAQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEC
PIAITVEGANILTRNLMIFGQGVMRCHPYLQSMVESIHSNEKSADKVFNGILRKTVSYSV
CEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GNSLRAFKLGLLPFTASAASTLAEVKPYEQSVHKLASKLAVYADFSLLVLGGKLKQAEML
CCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
SARLGDVMSYLYAAMASIRYYEKKLTAAEQKEAAPYFHYATRWSLCQAEKALLDFLDNFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSATRKFMRLVTVTYSAKMPKINDNLVRELAEQAQLNTEFKKNLTHLIKPVAGDGNDINE
CHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCH
QAYLAKMVCLPLLAKVKKAIRAKTFKPGVRFALTLDAALEAKVITSDEHKLLQDYNLKRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHEEEEEECCHHHHHHHCCCCHH
RAIRVDEFDFDMNLIDNKPELKIAN
HCCEEECCCCCCEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]