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The map label for this gene is kefC [H]

Identifier: 157961053

GI number: 157961053

Start: 1489454

End: 1491382

Strand: Reverse

Name: kefC [H]

Synonym: Spea_1225

Alternate gene names: 157961053

Gene position: 1491382-1489454 (Counterclockwise)

Preceding gene: 157961054

Following gene: 157961051

Centisome position: 28.82

GC content: 48.42

Gene sequence:

>1929_bases
ATGACTGCTTATTTTATTCAAGCTTTTATCTATTTATGCGCCGCCGTCATCGCCGTGCCTATTGCTAAGCGGCTCGGCCT
AGGCTCAGTGCTGGGCTATTTAATGGCAGGGGTAGTAATAGGGCCTATTATTGGTCTGGTCGGTGCCGAAACCAACACAC
TGCAGCACTTTGCCGAATTTGGCGTGGTGATGATGCTATTCCTAGTAGGTCTCGAACTTGAGCCCAAGATGCTCTGGAAT
ATGCGCAATAAACTTATTGGTTTAGGTGGACTTCAAGTAGGACTCTCTACCTTAGTGGTGATGGGTATCGCCCTGAGTTT
CGGCTATGGCTGGAGTATCGCCCTCACGGTGGGAATGATTTTCTCGCTGTCATCGACCGCTATCGTACTGCAGACCTTCA
ATGAGAAGAGTCTAACCAAAACCGAAGGCGGAAAGAATGCCTTTTCGGTGCTGTTATTTCAAGATATCGCCGTGATCCCT
ATGCTGGCGTTTATCCCGCTCTTGGCCTTGCCTGAACTCGTCGAAAAAGCTCAGTCTGTCACCCAAAGTGCTGCAGAGCA
CCATGAGGAGCTTTCGCTCGTCGCAGGTCTGCCGGGCTGGGCTTACGGAGTGGTCGTCTTGATGGCCATCGCTAGCGTCG
TGATTGGCGGTCATTATTTGAGTCGTCCGCTATTTCGCTATGTCGCCAGCTCAGGACTTAGGGAGATCTTTACTGCCACC
GCGCTTATGCTGGTTATTGGTATTGCTGCACTCATGAGCCTCGTAGGGCTATCTCCCGCACTAGGCACCTTCCTTGCGGG
CGTTGTATTGGCAAACAGTGAGTTTAGACACGAGCTTGAGTCCAATATCGAGCCTTTCAAGGGGCTATTACTCGGGTTAT
TTTTTATTACCGTGGGCGCAGGCATCAACTTCGATGTGCTGCTCAGTAATATCGGCCCAGTGATGGCAATGACCCTTGGG
GTCATTCTGATTAAGGCCGCTGTATTACTGGTACTGGCCTTTATTTTTAAGATCAGGGGCAGTGACCGTTGGCTATTTGC
CTTGAGCCTAGCGCAAGCGGGTGAGTTTGGTTTCGTGCTACTGAGTTACACAGTGCAAAACCATGTGATCCCTACCGAGC
TTGCTCAGTTACTGTCACTAGTGGTTGCCATATCCATGTTCCTCACACCAGGCCTATTCATTCTGTTTGATAAAGTCATT
TTACCCCGCTATGAAAAAACAGAAAATACACGAGAGCCTGATGATATCGACGAGACAGGCACTGTGATTATTGCCGGAGT
CGGCCGCTTTGGGCAGATAGTTAATCGCCTGCTGGTGACCAATGGTGTTAAAACAGTCGTACTGGATCATGAAGTTCAGC
AAATCGAAAACTTAAGGAAAATCAATACAAAAAGCTATTACGGCGATGCCACTCAGCCCGACTTACTCCATACTGCAGGT
ATCGAGCAGGCTAAGATGCTTGTCATTGCCATAGATGATCCTGAACGAGCCGTAGGTTTAGTCGAATATATCAAGCATAC
CCATCCCCATGTGATCGTGATGGCTCGCGCCTTTGATCGAAGGCACCTGTATCGTCTTCGTAATGCGGGGGCTGACTTTA
TGGTAAGCGAGACCTTCCATTCGGCGCTCAATTTAGGTAAGCATGCACTGATAAAACTTGGCGTACACCCGTTTAAGGCC
GAGCAACAGCGTGCAACTTTCTATGAGACCGAAACGACTCATAAAGACACTCTGTATGAGGCTTGGAAACAGTTCACCGA
AGACGATAAATACCTAGTACATTATCGCGATATGTTTATCCAGCTTGAAGAAACTCTAAGCGAAGCGATGAAAGACGAGC
GTTATCGCAGCTTTTCAAAAGTGGAGCGCAGCTGGACGCCACCTCCTAAGGAAAATCATACTGAATTTTCTAAAGCTGAA
AGCGATTAA

Upstream 100 bases:

>100_bases
CACTCAAGGCACTTAGTGAGGACAGATTCGATATCGAACAGGCTCAATCCCTTGAAAAACTCAATGGTCACCTCGACCAA
TTGATCCGGGAGCACTAATT

Downstream 100 bases:

>100_bases
CCAGGAACAATATCCAATAGAAAACGGTCAAAAAAAGCCCCCGTCACCGTTAGGTAGCGGGGGCTTATTATCTATTGTCT
AATGACAAGAATCGATCTTG

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MTAYFIQAFIYLCAAVIAVPIAKRLGLGSVLGYLMAGVVIGPIIGLVGAETNTLQHFAEFGVVMMLFLVGLELEPKMLWN
MRNKLIGLGGLQVGLSTLVVMGIALSFGYGWSIALTVGMIFSLSSTAIVLQTFNEKSLTKTEGGKNAFSVLLFQDIAVIP
MLAFIPLLALPELVEKAQSVTQSAAEHHEELSLVAGLPGWAYGVVVLMAIASVVIGGHYLSRPLFRYVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIEPFKGLLLGLFFITVGAGINFDVLLSNIGPVMAMTLG
VILIKAAVLLVLAFIFKIRGSDRWLFALSLAQAGEFGFVLLSYTVQNHVIPTELAQLLSLVVAISMFLTPGLFILFDKVI
LPRYEKTENTREPDDIDETGTVIIAGVGRFGQIVNRLLVTNGVKTVVLDHEVQQIENLRKINTKSYYGDATQPDLLHTAG
IEQAKMLVIAIDDPERAVGLVEYIKHTHPHVIVMARAFDRRHLYRLRNAGADFMVSETFHSALNLGKHALIKLGVHPFKA
EQQRATFYETETTHKDTLYEAWKQFTEDDKYLVHYRDMFIQLEETLSEAMKDERYRSFSKVERSWTPPPKENHTEFSKAE
SD

Sequences:

>Translated_642_residues
MTAYFIQAFIYLCAAVIAVPIAKRLGLGSVLGYLMAGVVIGPIIGLVGAETNTLQHFAEFGVVMMLFLVGLELEPKMLWN
MRNKLIGLGGLQVGLSTLVVMGIALSFGYGWSIALTVGMIFSLSSTAIVLQTFNEKSLTKTEGGKNAFSVLLFQDIAVIP
MLAFIPLLALPELVEKAQSVTQSAAEHHEELSLVAGLPGWAYGVVVLMAIASVVIGGHYLSRPLFRYVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIEPFKGLLLGLFFITVGAGINFDVLLSNIGPVMAMTLG
VILIKAAVLLVLAFIFKIRGSDRWLFALSLAQAGEFGFVLLSYTVQNHVIPTELAQLLSLVVAISMFLTPGLFILFDKVI
LPRYEKTENTREPDDIDETGTVIIAGVGRFGQIVNRLLVTNGVKTVVLDHEVQQIENLRKINTKSYYGDATQPDLLHTAG
IEQAKMLVIAIDDPERAVGLVEYIKHTHPHVIVMARAFDRRHLYRLRNAGADFMVSETFHSALNLGKHALIKLGVHPFKA
EQQRATFYETETTHKDTLYEAWKQFTEDDKYLVHYRDMFIQLEETLSEAMKDERYRSFSKVERSWTPPPKENHTEFSKAE
SD
>Mature_641_residues
TAYFIQAFIYLCAAVIAVPIAKRLGLGSVLGYLMAGVVIGPIIGLVGAETNTLQHFAEFGVVMMLFLVGLELEPKMLWNM
RNKLIGLGGLQVGLSTLVVMGIALSFGYGWSIALTVGMIFSLSSTAIVLQTFNEKSLTKTEGGKNAFSVLLFQDIAVIPM
LAFIPLLALPELVEKAQSVTQSAAEHHEELSLVAGLPGWAYGVVVLMAIASVVIGGHYLSRPLFRYVASSGLREIFTATA
LMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIEPFKGLLLGLFFITVGAGINFDVLLSNIGPVMAMTLGV
ILIKAAVLLVLAFIFKIRGSDRWLFALSLAQAGEFGFVLLSYTVQNHVIPTELAQLLSLVVAISMFLTPGLFILFDKVIL
PRYEKTENTREPDDIDETGTVIIAGVGRFGQIVNRLLVTNGVKTVVLDHEVQQIENLRKINTKSYYGDATQPDLLHTAGI
EQAKMLVIAIDDPERAVGLVEYIKHTHPHVIVMARAFDRRHLYRLRNAGADFMVSETFHSALNLGKHALIKLGVHPFKAE
QQRATFYETETTHKDTLYEAWKQFTEDDKYLVHYRDMFIQLEETLSEAMKDERYRSFSKVERSWTPPPKENHTEFSKAES
D

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=423, Percent_Identity=27.8959810874704, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786232, Length=632, Percent_Identity=43.5126582278481, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1789749, Length=615, Percent_Identity=40.4878048780488, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1786685, Length=529, Percent_Identity=27.4102079395085, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 70696; Mature: 70565

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYFIQAFIYLCAAVIAVPIAKRLGLGSVLGYLMAGVVIGPIIGLVGAETNTLQHFAEF
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWNMRNKLIGLGGLQVGLSTLVVMGIALSFGYGWSIALTVGMI
HHHHHHHHHCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FSLSSTAIVLQTFNEKSLTKTEGGKNAFSVLLFQDIAVIPMLAFIPLLALPELVEKAQSV
HHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQSAAEHHEELSLVAGLPGWAYGVVVLMAIASVVIGGHYLSRPLFRYVASSGLREIFTAT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIEPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GINFDVLLSNIGPVMAMTLGVILIKAAVLLVLAFIFKIRGSDRWLFALSLAQAGEFGFVL
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCEEE
LSYTVQNHVIPTELAQLLSLVVAISMFLTPGLFILFDKVILPRYEKTENTREPDDIDETG
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
TVIIAGVGRFGQIVNRLLVTNGVKTVVLDHEVQQIENLRKINTKSYYGDATQPDLLHTAG
CEEEEECCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
IEQAKMLVIAIDDPERAVGLVEYIKHTHPHVIVMARAFDRRHLYRLRNAGADFMVSETFH
CCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHH
SALNLGKHALIKLGVHPFKAEQQRATFYETETTHKDTLYEAWKQFTEDDKYLVHYRDMFI
HHHHCCHHHHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
QLEETLSEAMKDERYRSFSKVERSWTPPPKENHTEFSKAESD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAYFIQAFIYLCAAVIAVPIAKRLGLGSVLGYLMAGVVIGPIIGLVGAETNTLQHFAEF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWNMRNKLIGLGGLQVGLSTLVVMGIALSFGYGWSIALTVGMI
HHHHHHHHHCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FSLSSTAIVLQTFNEKSLTKTEGGKNAFSVLLFQDIAVIPMLAFIPLLALPELVEKAQSV
HHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQSAAEHHEELSLVAGLPGWAYGVVVLMAIASVVIGGHYLSRPLFRYVASSGLREIFTAT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIEPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GINFDVLLSNIGPVMAMTLGVILIKAAVLLVLAFIFKIRGSDRWLFALSLAQAGEFGFVL
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCEEE
LSYTVQNHVIPTELAQLLSLVVAISMFLTPGLFILFDKVILPRYEKTENTREPDDIDETG
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
TVIIAGVGRFGQIVNRLLVTNGVKTVVLDHEVQQIENLRKINTKSYYGDATQPDLLHTAG
CEEEEECCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
IEQAKMLVIAIDDPERAVGLVEYIKHTHPHVIVMARAFDRRHLYRLRNAGADFMVSETFH
CCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHH
SALNLGKHALIKLGVHPFKAEQQRATFYETETTHKDTLYEAWKQFTEDDKYLVHYRDMFI
HHHHCCHHHHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
QLEETLSEAMKDERYRSFSKVERSWTPPPKENHTEFSKAESD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA