Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 157960811

GI number: 157960811

Start: 1196074

End: 1197795

Strand: Reverse

Name: clcA [H]

Synonym: Spea_0983

Alternate gene names: 157960811

Gene position: 1197795-1196074 (Counterclockwise)

Preceding gene: 157960814

Following gene: 157960810

Centisome position: 23.15

GC content: 45.99

Gene sequence:

>1722_bases
TTGGAAATTCCTGTGCATCCAGCAATTGTTAAGAAGCGAGAGCAATTTCAAAAGTACTTACATACCGACCTTAAAGACAC
GCTTTCTCAGTCTAAGGTCAGTGTACAGTTATGTTTGCTCGCGTTGCTTTTTGCACTGTTTGCATCCGGTGTCATTGTTC
TTTTTAGGTTATTACTGGTCTGGTGCGACACCTTCACCAAAACCCAAGAGCTGAATTTTACGGACATCATCGATGACTGG
CGAGTATTATTACCGCTTTTCGGCTCCTTTTTAATCTGGGGTGTCGCAAAAATGGGATCTCAGCGCTATAAACGTATGGG
CATCGCCTATGTTATCCACAGAATGAAACTGCATTATGGCAAGATCCCGCTGCAGTCTGCCCCCGGACAATTTTTCCAAG
CTTTATTTGCCCTTGCCACCAACTTCTCTGTAGGACGAGAAGGACCGGCCATCCATTTAGGTGCCGTCAGTGCCAGTGTA
TTAGCGGAAAAGTTTAAGCTTCCCGATAACAGTGTTCGTGTCATGTGTGCCAGTGGTATTGCCGCTGGAATAGCGGCGAT
TTTTAACGCGCCACTCGCTGCCGTGATTTTTGTATTTGAAGTGGTGCTTAGGGAATACAAAATCCACTACTTCTTCCCGA
TCATGCTTTCAGCTATCTGCGGTGCACTCAGTAGTCAGTTGGTATTTGGTAATGTGCATGAATTCGAGCAGATCGGCGTT
GAAGTGATCCCTCTCAGCCAGTACCCACTGTTAGCTATATTCGGTTTGGTACTCGGTTGTATTGCAGCATTTTTTAATAC
CAGCCTATTAAAAATTACTGCCATCGGCCAAAAATGGCCGCTTATTAATCGTCTGTTACTTGCAGGTGCCGTTACTACCC
TAGTGGGGCTAGTTTTACCGCAAGCGATTGGTAGTGGTGAACTGGCTATTGCAGAGACCATTAATCAGCACCCGAGCATT
TTATTCTTAAGCGCGATTTTAGCTGGCAAGATCATCGCCACCATCGCCGCTATAGGCTTAGGCATTCCTGGTGGACTCAT
CGGCCCACTCTATGGAATAGGTGCTTTACTCGGCACCATATTGGCCTTAATTAGCGCCTTGTTTTTTCCAAGTATCGCGC
CCTATATTGGCTTATATACTATTATCGGCATGACAGGCATGATGGGCGTGTGTTTAAGCGCCCCACTCGCGGCACTAGTA
GCCTTAATCGAGCTGACAAATAACGCCTCGATTATTTTACCTTCTATGTTTGTGGTGATCCCTGCCTTCTTAATTGCTCA
TCAAGGCTTTAAGACCAAGTCTATATTCTTCAAACAGCTCGAGATAATGGGGCTGGGCTATAAAGTTGCGCCAGTAAATC
TTGGATTGCAGAAGGTCGGCGTGCGCCATCTCATGGATAAACGCTTCGTCATCGTTTACGACAACCAAGAACTATTACTA
GAGGTACTTAAGCGTGCAGAGGGTCGCTCTGTATTGGTACGCAATGCTCAAGGTGCTGTAGAGATGTTACAGCTTGAACT
GCAAGTCAGAGATCAAGACACCACCTTGACTCGTCATCCGATTCAGGGGCTGCCCGATACATCTACCCTCAATGAAGTAT
ACGCAATTCTTTCTAAGGAACGACGAGGGGAGGTTTATATCTATCAAGAGACAAATGAACAGATTGTTGGGGTGATTAAT
TGGGTCTCGCTGCGTAAAGAGATCCGTTCAGGGCAAGTGTAA

Upstream 100 bases:

>100_bases
CACTTGCAAGCGATCGGCCCAACGATGATAATTTGGCATTAAGTAACAGCCCCTTAATAAAAAATCTCACATTTTGAAAT
CAATGTGACAAACATAAATT

Downstream 100 bases:

>100_bases
ATTTATTCTCAAATCTACATACACTCATTTGCTTATAGAGAAGAGGCTCAAACCATTTAACAGCCGCTTAAGTACATTTG
AAACATTTACCAACCCAACT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MEIPVHPAIVKKREQFQKYLHTDLKDTLSQSKVSVQLCLLALLFALFASGVIVLFRLLLVWCDTFTKTQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRMKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGALSSQLVFGNVHEFEQIGV
EVIPLSQYPLLAIFGLVLGCIAAFFNTSLLKITAIGQKWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLSAILAGKIIATIAAIGLGIPGGLIGPLYGIGALLGTILALISALFFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFKQLEIMGLGYKVAPVNLGLQKVGVRHLMDKRFVIVYDNQELLL
EVLKRAEGRSVLVRNAQGAVEMLQLELQVRDQDTTLTRHPIQGLPDTSTLNEVYAILSKERRGEVYIYQETNEQIVGVIN
WVSLRKEIRSGQV

Sequences:

>Translated_573_residues
MEIPVHPAIVKKREQFQKYLHTDLKDTLSQSKVSVQLCLLALLFALFASGVIVLFRLLLVWCDTFTKTQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRMKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGALSSQLVFGNVHEFEQIGV
EVIPLSQYPLLAIFGLVLGCIAAFFNTSLLKITAIGQKWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLSAILAGKIIATIAAIGLGIPGGLIGPLYGIGALLGTILALISALFFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFKQLEIMGLGYKVAPVNLGLQKVGVRHLMDKRFVIVYDNQELLL
EVLKRAEGRSVLVRNAQGAVEMLQLELQVRDQDTTLTRHPIQGLPDTSTLNEVYAILSKERRGEVYIYQETNEQIVGVIN
WVSLRKEIRSGQV
>Mature_573_residues
MEIPVHPAIVKKREQFQKYLHTDLKDTLSQSKVSVQLCLLALLFALFASGVIVLFRLLLVWCDTFTKTQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRMKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGALSSQLVFGNVHEFEQIGV
EVIPLSQYPLLAIFGLVLGCIAAFFNTSLLKITAIGQKWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLSAILAGKIIATIAAIGLGIPGGLIGPLYGIGALLGTILALISALFFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFKQLEIMGLGYKVAPVNLGLQKVGVRHLMDKRFVIVYDNQELLL
EVLKRAEGRSVLVRNAQGAVEMLQLELQVRDQDTTLTRHPIQGLPDTSTLNEVYAILSKERRGEVYIYQETNEQIVGVIN
WVSLRKEIRSGQV

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=314, Percent_Identity=27.7070063694268, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081943, Length=401, Percent_Identity=24.4389027431421, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62612; Mature: 62612

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA