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The map label for this gene is glmU [H]

Identifier: 157960695

GI number: 157960695

Start: 1066891

End: 1067559

Strand: Direct

Name: glmU [H]

Synonym: Spea_0867

Alternate gene names: 157960695

Gene position: 1066891-1067559 (Clockwise)

Preceding gene: 157960694

Following gene: 157960696

Centisome position: 20.62

GC content: 46.64

Gene sequence:

>669_bases
ATGAAAGCGATGATTTTAGCGGCGGGGCGAGGAGAACGTCTACGGCCATTAACTGACTCTCTACCTAAACCTTTGGTCGA
GGTAGCAGGAAAACCTTTGATTGTTTATCACATCGAAAAACTTGCTGCTGCAGGTTTTACCGAAATAGTGATTAATCACG
CTTGGCTTGGTCACAAGCTGGTCGAGCTATTAGGTGACGGGCGTAAATGGCAAGTCAGCATTCAATATAGTGAAGAAACA
TCGGCGCTAGAAACAGGCGGCGGTATTAAGCAAGCACTGACTCTATTGGGCGATGAAGCATTTCTGGTTATTAACGGAGA
TATCTTCATCGATGAACTGCCTGAGATTAAACCACTTGAGGCGGGCACTCTTGCACACCTATGGCTTGTCGATAATCCGC
TGCAGCATCCCCATGGTGACTTTGCTTTGCAAGAGGGCAGGGTTTGTGAACAGGGGCTCGAGAAGCTAACATTTTCAGGT
ATAGGGGTTTATCACCCTCAATTATTCAGAGACACACCTGAAGGGGCCTTTGCATTAGCGCTCTTGTTACGCCAAGCCAT
GGCAAAGAGTCTGATTGGTGGTGCTCATTTTAAACAGTATTGGTGCGATGTGGGAACAGTGGAACGACTCGCACAAATAG
AAGCTCGTGAAACAAGTAAGGTTAGATAA

Upstream 100 bases:

>100_bases
ATTGAGCAACTGGATAGCAGAGGTGATTATTCCAGCGGTGAATGCCAAGAGTGATGTTGAGAGTGGCATTAGCATTGGTG
TAAAGAGTGAAGGGCAATAA

Downstream 100 bases:

>100_bases
TGCGTATTTGGGGTAAAGTTTTCGGCTTCATTATTGGATTTATGTTTGGCCGTATTGGTGGCGCTATTTTTGGGCTTTGG
TTAGGGCATATGTATGATCG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKAMILAAGRGERLRPLTDSLPKPLVEVAGKPLIVYHIEKLAAAGFTEIVINHAWLGHKLVELLGDGRKWQVSIQYSEET
SALETGGGIKQALTLLGDEAFLVINGDIFIDELPEIKPLEAGTLAHLWLVDNPLQHPHGDFALQEGRVCEQGLEKLTFSG
IGVYHPQLFRDTPEGAFALALLLRQAMAKSLIGGAHFKQYWCDVGTVERLAQIEARETSKVR

Sequences:

>Translated_222_residues
MKAMILAAGRGERLRPLTDSLPKPLVEVAGKPLIVYHIEKLAAAGFTEIVINHAWLGHKLVELLGDGRKWQVSIQYSEET
SALETGGGIKQALTLLGDEAFLVINGDIFIDELPEIKPLEAGTLAHLWLVDNPLQHPHGDFALQEGRVCEQGLEKLTFSG
IGVYHPQLFRDTPEGAFALALLLRQAMAKSLIGGAHFKQYWCDVGTVERLAQIEARETSKVR
>Mature_222_residues
MKAMILAAGRGERLRPLTDSLPKPLVEVAGKPLIVYHIEKLAAAGFTEIVINHAWLGHKLVELLGDGRKWQVSIQYSEET
SALETGGGIKQALTLLGDEAFLVINGDIFIDELPEIKPLEAGTLAHLWLVDNPLQHPHGDFALQEGRVCEQGLEKLTFSG
IGVYHPQLFRDTPEGAFALALLLRQAMAKSLIGGAHFKQYWCDVGTVERLAQIEARETSKVR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=114, Percent_Identity=38.5964912280702, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI11761619, Length=114, Percent_Identity=38.5964912280702, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788351, Length=146, Percent_Identity=30.8219178082192, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=113, Percent_Identity=38.9380530973451, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509979, Length=120, Percent_Identity=38.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=114, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355443, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644084, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 24408; Mature: 24408

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDSLPKPLVEVAGKPLIVYHIEKLAAAGFTEIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHH
VELLGDGRKWQVSIQYSEETSALETGGGIKQALTLLGDEAFLVINGDIFIDELPEIKPLE
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHHHHHCCCEEEEEECCEEECCCCCCCCCC
AGTLAHLWLVDNPLQHPHGDFALQEGRVCEQGLEKLTFSGIGVYHPQLFRDTPEGAFALA
CCCEEEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHH
LLLRQAMAKSLIGGAHFKQYWCDVGTVERLAQIEARETSKVR
HHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDSLPKPLVEVAGKPLIVYHIEKLAAAGFTEIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHH
VELLGDGRKWQVSIQYSEETSALETGGGIKQALTLLGDEAFLVINGDIFIDELPEIKPLE
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHHHHHCCCEEEEEECCEEECCCCCCCCCC
AGTLAHLWLVDNPLQHPHGDFALQEGRVCEQGLEKLTFSGIGVYHPQLFRDTPEGAFALA
CCCEEEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHH
LLLRQAMAKSLIGGAHFKQYWCDVGTVERLAQIEARETSKVR
HHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]