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The map label for this gene is hpt [H]

Identifier: 157960516

GI number: 157960516

Start: 849917

End: 850450

Strand: Direct

Name: hpt [H]

Synonym: Spea_0688

Alternate gene names: 157960516

Gene position: 849917-850450 (Clockwise)

Preceding gene: 157960515

Following gene: 157960517

Centisome position: 16.42

GC content: 42.88

Gene sequence:

>534_bases
ATGAAACACACCACTGAAGTGATGATCACTGCTGAAGAGATCGATCAAAAATTGGATATTTTGGCTGAGCAGATTAATGC
ACATTATGCCGATAGCGACCGCCTGTTGATGGTAGGTTTACTGAAAGGTTCTGTTGTTTTTATGGCAGATCTTTGTAGAC
GTATTAAAGGTCATGTTGAGATCGACTTTATGTCGGTATCAAGCTATGGCAACGAAATGAGCAGCAGCCGCGACGTAAAA
ATTCTTAAAGACGTGCAGTCTGAAATTCAGGGTCGTGATGTGTTGATCGTTGAAGATCTTATCGATTCAGGCAATACCTT
AAACAAGGTACGCGATATGCTATTGCTACGAGAGCCAAAGAGTTTGGCGCTTTGTACGCTATTAGATAAGCCTGAACGCC
GTGAAGTTGACGTACCAGTCGATTTTATTGGCTTTACTATCCCTGACGAGTTCATCGTGGGCTATGGTATCGACTATGCG
GAGCAGTATCGTAACCTGCCGTATATCGCTAAAGTTGTACCGTTAGAAGACTAA

Upstream 100 bases:

>100_bases
GTCGCTCGAATTCTTGACCATTTGGGCGTTAACCATGCACTAACGAATCGTTGGGGTTATGACAAGCATAACGTTAGCGA
CATCGACTACTGAGAGTTTT

Downstream 100 bases:

>100_bases
ACTAGAAGTTACGTTACGGCGCGATTACATAGGTAAAGTTACCTGAGTTGATTGGCACCTAACCTAATACAATGACTCCC
GCAATCGCGGGAGTTTTTAT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNEMSSSRDVK
ILKDVQSEIQGRDVLIVEDLIDSGNTLNKVRDMLLLREPKSLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLED

Sequences:

>Translated_177_residues
MKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNEMSSSRDVK
ILKDVQSEIQGRDVLIVEDLIDSGNTLNKVRDMLLLREPKSLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLED
>Mature_177_residues
MKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNEMSSSRDVK
ILKDVQSEIQGRDVLIVEDLIDSGNTLNKVRDMLLLREPKSLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLED

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=162, Percent_Identity=34.5679012345679, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=31.2138728323699, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI87081689, Length=178, Percent_Identity=64.6067415730337, Blast_Score=241, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17510817, Length=161, Percent_Identity=34.7826086956522, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20078; Mature: 20078

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVE
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNTLNKVRDMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLED
HHEEEEECCCCCCCCCCCCHHEEEECCCCHHHEECCCCHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVE
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNTLNKVRDMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLED
HHEEEEECCCCCCCCCCCCHHEEEECCCCHHHEECCCCHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]