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The map label for this gene is cysG1 [H]

Identifier: 157960490

GI number: 157960490

Start: 821127

End: 821942

Strand: Direct

Name: cysG1 [H]

Synonym: Spea_0662

Alternate gene names: 157960490

Gene position: 821127-821942 (Clockwise)

Preceding gene: 157960486

Following gene: 157960491

Centisome position: 15.87

GC content: 49.75

Gene sequence:

>816_bases
ATGGAGATTGTAACTTTACCGGGTCAAGCCGCTGGAGGAAAAGTATGGCTAGTGGGAGCGGGTCCTGGTGATGTCGATCT
GCTGACGGTAAAAGCCTATCGGGTGCTGCGAAATGCCGACGCGGTACTTTACGACGCGCTCGTTAGTGAAGAGATCCTTG
CGCTAATCCCCAAGCATGCTGAGAAAATAGCCGTTGGTAAACGAGCAGGCCTTCACAGTGCGGCACAAAGCGAGATTAAT
CAGCTACTGGTGACCAAGGCCTACACTCGCAAGAATGTGGTGCGCTTAAAGGGTGGCGATCCATTTATTTTCGGCCGTGG
TGGTGAAGAGCTAGAAACTATCGTTGCTGCGGGTGTTGATTTCGAGGTTGTGCCAGGTATTACCGCTGCAAGCGGCACGG
CAGCATATGCTGGTATCCCATTAACCCATAGGGATTACGCTCAAGGCGTGAGCTTTATTACCGGCCATTACAAGTTAGAG
AGCCGACCTATGGATTGGCAAAGTTATGCCAATCCTAATAATACCTTAGTGATCTATATGGGGATCTTAAACGCAGGGCT
AATCAAGCAAGGCTTGCTCGATGCGGGGAGAAAGGCTGCAACGCCTGTGGCCATCGTATCGAAAGCGACCACGAGCCAGC
AGCGGGTCTTTATCGGTAGCTTAGACAATATAGACGAGCTAGCCAGCCATCCAGAGCTTGTTATGCCTGCTTTGATGGTT
ATCGGTGAGGTGGTTGAATTAGCCGATAGCCTAAATTGGTTTACGCCACAGGCAAACCAGATTAAGCATTCTGATTTAGC
TGCACAAATTAAATAA

Upstream 100 bases:

>100_bases
CTTAAATAACAAAAAGTTATAACAACTAATAAATATCTATTTATTATGGAATAAGGAGGCGGCTATATTTCAGTACAAGA
AATCACAGTGAGGTAGCGCT

Downstream 100 bases:

>100_bases
TTGATTGAAGAAAACGGAGAATTAGCATGGCCGCGAAAGAGTTAAGCCATTTGCAACAACTGGAAGCTGAGAGCATTCAA
ATCATCCGCGAAGTGGCGGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MEIVTLPGQAAGGKVWLVGAGPGDVDLLTVKAYRVLRNADAVLYDALVSEEILALIPKHAEKIAVGKRAGLHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVAAGVDFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHYKLE
SRPMDWQSYANPNNTLVIYMGILNAGLIKQGLLDAGRKAATPVAIVSKATTSQQRVFIGSLDNIDELASHPELVMPALMV
IGEVVELADSLNWFTPQANQIKHSDLAAQIK

Sequences:

>Translated_271_residues
MEIVTLPGQAAGGKVWLVGAGPGDVDLLTVKAYRVLRNADAVLYDALVSEEILALIPKHAEKIAVGKRAGLHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVAAGVDFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHYKLE
SRPMDWQSYANPNNTLVIYMGILNAGLIKQGLLDAGRKAATPVAIVSKATTSQQRVFIGSLDNIDELASHPELVMPALMV
IGEVVELADSLNWFTPQANQIKHSDLAAQIK
>Mature_271_residues
MEIVTLPGQAAGGKVWLVGAGPGDVDLLTVKAYRVLRNADAVLYDALVSEEILALIPKHAEKIAVGKRAGLHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVAAGVDFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHYKLE
SRPMDWQSYANPNNTLVIYMGILNAGLIKQGLLDAGRKAATPVAIVSKATTSQQRVFIGSLDNIDELASHPELVMPALMV
IGEVVELADSLNWFTPQANQIKHSDLAAQIK

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=54.7325102880658, Blast_Score=262, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322922, Length=242, Percent_Identity=35.1239669421488, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 28879; Mature: 28879

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVTLPGQAAGGKVWLVGAGPGDVDLLTVKAYRVLRNADAVLYDALVSEEILALIPKHA
CEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EKIAVGKRAGLHSAAQSEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVAAGVD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHYKLESRPMDWQSYANPNNTLVIYM
EEECCCCEECCCCCEEECCCCCCHHHHCCHHEEEEEEEECCCCCCHHHHCCCCCEEEEEE
GILNAGLIKQGLLDAGRKAATPVAIVSKATTSQQRVFIGSLDNIDELASHPELVMPALMV
HHHCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHH
IGEVVELADSLNWFTPQANQIKHSDLAAQIK
HHHHHHHHHHCCCCCCCCCCCCCCCHHEECC
>Mature Secondary Structure
MEIVTLPGQAAGGKVWLVGAGPGDVDLLTVKAYRVLRNADAVLYDALVSEEILALIPKHA
CEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EKIAVGKRAGLHSAAQSEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVAAGVD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHYKLESRPMDWQSYANPNNTLVIYM
EEECCCCEECCCCCEEECCCCCCHHHHCCHHEEEEEEEECCCCCCHHHHCCCCCEEEEEE
GILNAGLIKQGLLDAGRKAATPVAIVSKATTSQQRVFIGSLDNIDELASHPELVMPALMV
HHHCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHH
IGEVVELADSLNWFTPQANQIKHSDLAAQIK
HHHHHHHHHHCCCCCCCCCCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA