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The map label for this gene is tpm

Identifier: 157960417

GI number: 157960417

Start: 721765

End: 722424

Strand: Direct

Name: tpm

Synonym: Spea_0588

Alternate gene names: 157960417

Gene position: 721765-722424 (Clockwise)

Preceding gene: 157960416

Following gene: 157960420

Centisome position: 13.95

GC content: 47.58

Gene sequence:

>660_bases
ATGCAGCCAAGTTTTTGGCACGACAAATGGGATGCCCAGCAGGTTGGCTTTCATTTGAGTGCAGTTAATCCCCTTCTTGT
AAAATACTGGCCACAGCTTGAGCTCGACGCAAATGCTCAGGTATTTGTTCCTCTGTGCGGCAAATCATTAGATATGTGCT
TCTTGGCAGAGCAGGGCCATGAAGTCTTGGGCTGCGAGTTAAACGAGTTAGCAGTGCAGCAGTTTTACCGTGAAAATGAA
CTTGCTTTTGACATTTCTACACTAGCTGAACACCAACGTTTTCACACCGAACAAGTCACCATCTATCAGGGCGATATTTT
TAGCCTCGATGCTGCTGAGATGCCAAATACTCAGGCGTTTTACGATCGCGCCGCCCTGATTGCTTGGCCTGAAGAGATGC
GTTCAGCCTATGCTCGGCAACTCGCTAAGCTCGTTCCTGCCAATAGTACTGGTTTACTTATCACTTTAGATTACCCGCAG
GCAGAGCTCAATGGGCCACCCTTTGCCGTATCCGATGATTGGGTACAGGCAAACCTAGCCACAGACTTTGAGATAGAGCG
CTTATCGAGTGAAGATGTGCTCAGTGAGAACCCTCGCTTTGTTAACAAGCAGGTTTCATGGCTGACAGAGTCGGTTTATA
AGTTAATACGGAAAGGTTGA

Upstream 100 bases:

>100_bases
TTTCAGTGAGAGCTAACTTCAGTGAGATCTTACCCGTTCTTAGCTGATGATATTCAAGTGCTAGGTCATACCTTGGTTTT
CTTTGATATGGACCTTGAAT

Downstream 100 bases:

>100_bases
AAAAGCAGGTTCTAGGGAAGTAGGTTCTAGGTTTTAGGAAAGGCAAAGACGGTAAAAACCGGGTAAAGCAAGGAAAGCAG
AGACGGTAAAGGCGGAAAAG

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGHEVLGCELNELAVQQFYRENE
LAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAFYDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQ
AELNGPPFAVSDDWVQANLATDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG

Sequences:

>Translated_219_residues
MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGHEVLGCELNELAVQQFYRENE
LAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAFYDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQ
AELNGPPFAVSDDWVQANLATDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG
>Mature_219_residues
MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGHEVLGCELNELAVQQFYRENE
LAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAFYDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQ
AELNGPPFAVSDDWVQANLATDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=29.2237442922374, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_SHEPA (A8H029)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001500451.1
- ProteinModelPortal:   A8H029
- SMR:   A8H029
- STRING:   A8H029
- GeneID:   5660988
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_0588
- NMPDR:   fig|398579.3.peg.517
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   FAVSNDW
- ProtClustDB:   PRK13255
- BioCyc:   SPEA398579:SPEA_0588-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24972; Mature: 24972

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGH
CCCCCCCCCCCHHHHCEEHCCCCHHHHHHCCCEEECCCCEEEEEECCCCCCEEEEECCCC
EVLGCELNELAVQQFYRENELAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAF
EEECCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCCHHH
YDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQAELNGPPFAVSDDWVQANLA
HHCCCEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCCCCCEEECCCCEEEECC
TDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG
CCCCHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGH
CCCCCCCCCCCHHHHCEEHCCCCHHHHHHCCCEEECCCCEEEEEECCCCCCEEEEECCCC
EVLGCELNELAVQQFYRENELAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAF
EEECCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCCHHH
YDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQAELNGPPFAVSDDWVQANLA
HHCCCEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCCCCCEEECCCCEEEECC
TDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG
CCCCHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA