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The map label for this gene is gppA [H]

Identifier: 157960229

GI number: 157960229

Start: 482881

End: 483792

Strand: Direct

Name: gppA [H]

Synonym: Spea_0400

Alternate gene names: 157960229

Gene position: 482881-483792 (Clockwise)

Preceding gene: 157960228

Following gene: 157960230

Centisome position: 9.33

GC content: 43.42

Gene sequence:

>912_bases
ATGAAACCACCTCTTTATGCTGCCATTACGTTAGGCTCAAATAGTTTTAATATGCTGGTCGCGAAAACCGTTGCTCAGCA
GCCTAAAGTTATTGCCAAGTACAAACGTAAGGTCCGCTTAGCCGAAGGGATCCAGGCCGATGGTTCCCTGAGTGAAGAGG
TGCTATTACGTGGTTTAGATTGTCTAACCATGTTCGCAGAGATGCTCCGCAAAGAAGGTATTTCTGCTAATAATGTAGCT
GTGATTGCCACGGCTACATTGAGAAATATTTCTAACTCTGATGACTTTTGTCGGCGAGCCTTCCCCATTCTAGGTCACCC
TATCGAGATTATTTCTGGCATGCGAGAGGCCGAGCTTATCTATCTGGGTATGGTCGCGACCACTGCAGGTGAGGGGCGTC
GCCTTGTCATCGATATTGGTGGAGCTAGCACCGAGTTTATTATTGGCGATGGTACAAAGGTATTACTGAAGACCAGTTTA
CCTATGGGCTGTGTCACTTTTAATGAATCTTTTTTTAGTAATTTCCCATTCCAACAATTAGATTTTGATGACGCTAAAGC
CAAGGTAAAAGCAGTACTTGGTGAGCAACTTTCAGAGCTTAAATCATTAGGTTGGCACTGTGTTGTTGGCGCATCGGGAA
GTGTTCAGTCGGTAGTCGAACTCCTCAATCATCGTAACCTTTCAGCGGTTGTTACCTTAGATGTTTTACTGGATTTAAAG
CAGGAAATTTTAGCGCAAAATAGTGTGTCTATGCAGGCTATCCCTGGTTTAAATCATGAAAGAGCTCCCACATTTACAGC
TGGTATTTCAATTCTGCTGGCCCTGTTTGAATTACTTGAAATAGAAAAACTTCACCTTTCAGGTGGCGCATTACGTGAAG
GGGTTTTACAAACCTTAGCCTGTAATATTTAG

Upstream 100 bases:

>100_bases
AATACTCGTGATCGTAGTTCTGGTCGTCCACAGGGTGGGCAGCGCAATGGACCTCGACGTCATGACAAAACGCGTAGACA
TTCGTAGGCGATAAAGCTTA

Downstream 100 bases:

>100_bases
ATCCATTTCTTGTTCTCACTATTTTTAGTTACCCTCCTCAGAAAATAAGTCGTACAACTTCGCTTCTTTATTCTAAATGT
ATTGGTATTTTACCCTTAGC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKPPLYAAITLGSNSFNMLVAKTVAQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLTMFAEMLRKEGISANNVA
VIATATLRNISNSDDFCRRAFPILGHPIEIISGMREAELIYLGMVATTAGEGRRLVIDIGGASTEFIIGDGTKVLLKTSL
PMGCVTFNESFFSNFPFQQLDFDDAKAKVKAVLGEQLSELKSLGWHCVVGASGSVQSVVELLNHRNLSAVVTLDVLLDLK
QEILAQNSVSMQAIPGLNHERAPTFTAGISILLALFELLEIEKLHLSGGALREGVLQTLACNI

Sequences:

>Translated_303_residues
MKPPLYAAITLGSNSFNMLVAKTVAQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLTMFAEMLRKEGISANNVA
VIATATLRNISNSDDFCRRAFPILGHPIEIISGMREAELIYLGMVATTAGEGRRLVIDIGGASTEFIIGDGTKVLLKTSL
PMGCVTFNESFFSNFPFQQLDFDDAKAKVKAVLGEQLSELKSLGWHCVVGASGSVQSVVELLNHRNLSAVVTLDVLLDLK
QEILAQNSVSMQAIPGLNHERAPTFTAGISILLALFELLEIEKLHLSGGALREGVLQTLACNI
>Mature_303_residues
MKPPLYAAITLGSNSFNMLVAKTVAQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLTMFAEMLRKEGISANNVA
VIATATLRNISNSDDFCRRAFPILGHPIEIISGMREAELIYLGMVATTAGEGRRLVIDIGGASTEFIIGDGTKVLLKTSL
PMGCVTFNESFFSNFPFQQLDFDDAKAKVKAVLGEQLSELKSLGWHCVVGASGSVQSVVELLNHRNLSAVVTLDVLLDLK
QEILAQNSVSMQAIPGLNHERAPTFTAGISILLALFELLEIEKLHLSGGALREGVLQTLACNI

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=292, Percent_Identity=44.8630136986301, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788848, Length=296, Percent_Identity=39.8648648648649, Blast_Score=221, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 32699; Mature: 32699

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPLYAAITLGSNSFNMLVAKTVAQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLD
CCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLTMFAEMLRKEGISANNVAVIATATLRNISNSDDFCRRAFPILGHPIEIISGMREAELI
HHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHEE
YLGMVATTAGEGRRLVIDIGGASTEFIIGDGTKVLLKTSLPMGCVTFNESFFSNFPFQQL
EEEEEEECCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCEEEEECHHHHCCCCCCCC
DFDDAKAKVKAVLGEQLSELKSLGWHCVVGASGSVQSVVELLNHRNLSAVVTLDVLLDLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
QEILAQNSVSMQAIPGLNHERAPTFTAGISILLALFELLEIEKLHLSGGALREGVLQTLA
HHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CNI
CCC
>Mature Secondary Structure
MKPPLYAAITLGSNSFNMLVAKTVAQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLD
CCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLTMFAEMLRKEGISANNVAVIATATLRNISNSDDFCRRAFPILGHPIEIISGMREAELI
HHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHEE
YLGMVATTAGEGRRLVIDIGGASTEFIIGDGTKVLLKTSLPMGCVTFNESFFSNFPFQQL
EEEEEEECCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCEEEEECHHHHCCCCCCCC
DFDDAKAKVKAVLGEQLSELKSLGWHCVVGASGSVQSVVELLNHRNLSAVVTLDVLLDLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
QEILAQNSVSMQAIPGLNHERAPTFTAGISILLALFELLEIEKLHLSGGALREGVLQTLA
HHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CNI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA