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The map label for this gene is mpg1 [H]

Identifier: 157960129

GI number: 157960129

Start: 336532

End: 337725

Strand: Reverse

Name: mpg1 [H]

Synonym: Spea_0300

Alternate gene names: 157960129

Gene position: 337725-336532 (Counterclockwise)

Preceding gene: 157960130

Following gene: 157960128

Centisome position: 6.53

GC content: 44.39

Gene sequence:

>1194_bases
ATGAAAGGAATGATACTCGCCGCAGGGAAAGGCACTCGAATAAAACCAATCTCTTATGCGATTCCAAAGCCAATGGTACC
AATTCTAGGTAAGCCCGTTATGGAGTCTATGATTCAATTGTTTGCCAAACATGGCATAGATAAAATAGTCATTAATACCA
GTCACTTGGCCGAGATAATCGAAAGTTATTTTGGAGATGGGCACCATTTCAATGTGCAGCTTTCCTATTCCTATGAAGCG
AAAGAAGTTAATGGTGAATACATCAGCCAAGCTCTAGGCAGTGCTGGCGGCATGAGAAAAATACAAGATTTTTCAGGCTT
TTTTGACGAAACCTTCGTGGTCGTTTGCGGTGATGCGTGGATCGATCTTGATCTCAAGCAAGCAATAGAACACCACAAAA
GCCATGGTGGACTCGCCACTATCATCACTCGAGAAGTCGCATCTTCTGAAGTGAGTAAATATGGCGTAGTGGTCACAGAT
AAACACAATCAAGTCACCAGCTTTCAAGAAAAACCAGCCGAAGATGAGGCTCTTTCAAATAGAATCAACACGGGTATCTA
TATATTTGAACCAGCAATTTTTGACTTTATTCCTAAAGATGTCGAATTTGATATTGGCAGCGATCTGTTTCCACTGCTTG
TGGAAAGACAGGCTAACCTTTACGCAATAAACATGGACTTCCAATGGCTTGATGTGGGCAAAGTGAAAGACGTATGGGAA
GTCACCAGTGACATTCTAAACGGTAATGTTAAAGGCTATCCCATCCCCGGCACTCAAGTTTCTCCCGGAGTCTGGGTGGG
CATCAACACTCGTGTCGACACCACAAAATGTAAAATCACCCCGCCGGTTATCATCAGCAGCGGCAGCGAAGTGCAGGATG
GTGCCACCATCATAGGCCCTACGGTTATCGGAGCAAACTGCAAGGTGGAAGGCAGGAGCCTAGTTAGCAACACGCTTATT
TGCGACTACATTCACCTCGCCGATGATGCCTATATCGTCAATAAGACCATGTTCGGTGACTACCTACTGGGCCATGATGG
TTACACCCAGCTGTTATCGGACTGCCAATATGTGCATATTCTTAAAAATCGCAACGTCTCACGCCCCCTATTAGCTAAAA
ACAGTGCTGAAGATATTTATTTAGCACTGAGTACTCCAGCAACACTTCCAACGCCTTTACAGCAAGTTAAATAG

Upstream 100 bases:

>100_bases
ATTGTCGATCTATTAAAACTGACTCGCATGGATAAGCTCATCCTAAGTCACCCCACAATAGAAGCTGCACTGACTACTAC
AGCGTAAAGAGGCATATCGA

Downstream 100 bases:

>100_bases
GGAGTTTAAACCGTGAGAACAAGGACGTTTCACCAACAATATTCAAGTTGCTTAGAAGCATCTAGGCTTGTTGCCTCCGA
TATAGTTCCTTTTTGGCGGC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKGMILAAGKGTRIKPISYAIPKPMVPILGKPVMESMIQLFAKHGIDKIVINTSHLAEIIESYFGDGHHFNVQLSYSYEA
KEVNGEYISQALGSAGGMRKIQDFSGFFDETFVVVCGDAWIDLDLKQAIEHHKSHGGLATIITREVASSEVSKYGVVVTD
KHNQVTSFQEKPAEDEALSNRINTGIYIFEPAIFDFIPKDVEFDIGSDLFPLLVERQANLYAINMDFQWLDVGKVKDVWE
VTSDILNGNVKGYPIPGTQVSPGVWVGINTRVDTTKCKITPPVIISSGSEVQDGATIIGPTVIGANCKVEGRSLVSNTLI
CDYIHLADDAYIVNKTMFGDYLLGHDGYTQLLSDCQYVHILKNRNVSRPLLAKNSAEDIYLALSTPATLPTPLQQVK

Sequences:

>Translated_397_residues
MKGMILAAGKGTRIKPISYAIPKPMVPILGKPVMESMIQLFAKHGIDKIVINTSHLAEIIESYFGDGHHFNVQLSYSYEA
KEVNGEYISQALGSAGGMRKIQDFSGFFDETFVVVCGDAWIDLDLKQAIEHHKSHGGLATIITREVASSEVSKYGVVVTD
KHNQVTSFQEKPAEDEALSNRINTGIYIFEPAIFDFIPKDVEFDIGSDLFPLLVERQANLYAINMDFQWLDVGKVKDVWE
VTSDILNGNVKGYPIPGTQVSPGVWVGINTRVDTTKCKITPPVIISSGSEVQDGATIIGPTVIGANCKVEGRSLVSNTLI
CDYIHLADDAYIVNKTMFGDYLLGHDGYTQLLSDCQYVHILKNRNVSRPLLAKNSAEDIYLALSTPATLPTPLQQVK
>Mature_397_residues
MKGMILAAGKGTRIKPISYAIPKPMVPILGKPVMESMIQLFAKHGIDKIVINTSHLAEIIESYFGDGHHFNVQLSYSYEA
KEVNGEYISQALGSAGGMRKIQDFSGFFDETFVVVCGDAWIDLDLKQAIEHHKSHGGLATIITREVASSEVSKYGVVVTD
KHNQVTSFQEKPAEDEALSNRINTGIYIFEPAIFDFIPKDVEFDIGSDLFPLLVERQANLYAINMDFQWLDVGKVKDVWE
VTSDILNGNVKGYPIPGTQVSPGVWVGINTRVDTTKCKITPPVIISSGSEVQDGATIIGPTVIGANCKVEGRSLVSNTLI
CDYIHLADDAYIVNKTMFGDYLLGHDGYTQLLSDCQYVHILKNRNVSRPLLAKNSAEDIYLALSTPATLPTPLQQVK

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=354, Percent_Identity=26.271186440678, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI11761619, Length=328, Percent_Identity=27.1341463414634, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790224, Length=256, Percent_Identity=25.78125, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788351, Length=252, Percent_Identity=26.1904761904762, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789837, Length=271, Percent_Identity=22.8782287822878, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=357, Percent_Identity=31.3725490196078, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17509979, Length=313, Percent_Identity=27.4760383386581, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=302, Percent_Identity=27.1523178807947, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=331, Percent_Identity=31.4199395770393, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21355443, Length=378, Percent_Identity=29.3650793650794, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24644084, Length=378, Percent_Identity=29.3650793650794, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24653912, Length=206, Percent_Identity=29.6116504854369, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 43627; Mature: 43627

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGMILAAGKGTRIKPISYAIPKPMVPILGKPVMESMIQLFAKHGIDKIVINTSHLAEII
CCCEEEECCCCCEECEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
ESYFGDGHHFNVQLSYSYEAKEVNGEYISQALGSAGGMRKIQDFSGFFDETFVVVCGDAW
HHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCE
IDLDLKQAIEHHKSHGGLATIITREVASSEVSKYGVVVTDKHNQVTSFQEKPAEDEALSN
EECCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHH
RINTGIYIFEPAIFDFIPKDVEFDIGSDLFPLLVERQANLYAINMDFQWLDVGKVKDVWE
HCCCCEEEECCHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECEEEEECCCHHHHHH
VTSDILNGNVKGYPIPGTQVSPGVWVGINTRVDTTKCKITPPVIISSGSEVQDGATIIGP
HHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCCCCCCEEECC
TVIGANCKVEGRSLVSNTLICDYIHLADDAYIVNKTMFGDYLLGHDGYTQLLSDCQYVHI
EEECCCCEECCCHHHHCCCEEEEEEECCCEEEEEEEEECCEEECCCCHHHHHHCCEEEEE
LKNRNVSRPLLAKNSAEDIYLALSTPATLPTPLQQVK
ECCCCCCCCHHCCCCCCCEEEEEECCCCCCCCHHHCC
>Mature Secondary Structure
MKGMILAAGKGTRIKPISYAIPKPMVPILGKPVMESMIQLFAKHGIDKIVINTSHLAEII
CCCEEEECCCCCEECEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
ESYFGDGHHFNVQLSYSYEAKEVNGEYISQALGSAGGMRKIQDFSGFFDETFVVVCGDAW
HHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCE
IDLDLKQAIEHHKSHGGLATIITREVASSEVSKYGVVVTDKHNQVTSFQEKPAEDEALSN
EECCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHH
RINTGIYIFEPAIFDFIPKDVEFDIGSDLFPLLVERQANLYAINMDFQWLDVGKVKDVWE
HCCCCEEEECCHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECEEEEECCCHHHHHH
VTSDILNGNVKGYPIPGTQVSPGVWVGINTRVDTTKCKITPPVIISSGSEVQDGATIIGP
HHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCCCCCCEEECC
TVIGANCKVEGRSLVSNTLICDYIHLADDAYIVNKTMFGDYLLGHDGYTQLLSDCQYVHI
EEECCCCEECCCHHHHCCCEEEEEEECCCEEEEEEEEECCEEECCCCHHHHHHCCEEEEE
LKNRNVSRPLLAKNSAEDIYLALSTPATLPTPLQQVK
ECCCCCCCCHHCCCCCCCEEEEEECCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]