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The map label for this gene is tdh [H]

Identifier: 157959936

GI number: 157959936

Start: 118993

End: 120018

Strand: Reverse

Name: tdh [H]

Synonym: Spea_0106

Alternate gene names: 157959936

Gene position: 120018-118993 (Counterclockwise)

Preceding gene: 157959937

Following gene: 157959935

Centisome position: 2.32

GC content: 48.25

Gene sequence:

>1026_bases
ATGAAAGCACTCAGCAAGCTAAAGCCTGAAGAAGGCATCTGGATGGTAGATGCGCCTAAACCAGAAGTGGGCCATAACGA
TCTATTAATTAAAATTCGTAAGACCGCTATCTGCGGTACCGACGTTCATATCTACAACTGGGATGAGTGGTCACAAAACA
CCATTCCTGTGCCTATGGTTGTTGGTCATGAATATGTGGGTGAAGTTGTCGGTATGGGCCAAGAAGTACGTGGCTTTACT
ATTGGCGACCGTGTTTCCGGTGAAGGCCATATTACTTGCGGCCATTGCCGTAACTGTCGTGGTGGTCGCACTCACTTATG
CCGCAATACTTCGGGTGTCGGCGTTAACCGTGAAGGTGCCTTTGCTGAATACCTAGTTATCCCAGCATTTAACGCCTTTA
AGATCCCTGATGATATCTCTGATGATTTGGCCTCTATCTTCGATCCATTTGGTAACGCGGTGCATACTGCGCTGTCATTC
GATCTTGTCGGTGAAGACGTTCTTATTACTGGTGCAGGCCCAATTGGCATTATGGCAGCGGCCGTATGTCGTCACGTTGG
TGCGCGCCATGTGGTGATCACCGATGTGAACGAATACCGCCTAGAGCTAGCCGAGAAAATGGGAGCGACCCGTGCAGTTA
ACGTCGCCAAAGAGAATCTTGAAGATGTAATGCAAGAGCTCGGTATGACAGAAGGCTTCGATGTAGGTCTAGAGATGTCA
GGCGTGCCTTCGGCATTCCACTCTATGCTCGACACCATGAACCACGGTGGCAAAATTGCCATGCTAGGTATTCCAGGTGG
CGACATGGCTATCGACTGGAGCAAGGTGATCTTTAAAGGGCTTATCATTAAGGGCATTTATGGCCGTGAGATGTTTGAGA
CCTGGTATAAGATGGCAAGCCTTATCCAATCTGGACTCGATATTTCGCCAATCATCACCCACCATTATAGTATTGATGAG
TTCCAGCAAGGCTTTGATGCCATGCGTTCAGGTCAATCAGGTAAAGTGATCCTCAACTGGGATTAA

Upstream 100 bases:

>100_bases
TGGGTATCATCAGCTAAAATCAAATCAATAGGGGCTACGTATGTAGCCCTTTTTGAATGACATTCAGCAAGCCGCAAGCC
GGCCTGTAATAGGTTATAAA

Downstream 100 bases:

>100_bases
ATCATTAGCCAGCTTTTGATTTATTCTCCGAACAAGTGACTGTAATATCTGCTTGAGACTATTACAGTCGCTTTTGTCTT
CTCTAATCTAATCAATACAG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRGFT
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMS
GVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLIQSGLDISPIITHHYSIDE
FQQGFDAMRSGQSGKVILNWD

Sequences:

>Translated_341_residues
MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRGFT
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMS
GVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLIQSGLDISPIITHHYSIDE
FQQGFDAMRSGQSGKVILNWD
>Mature_341_residues
MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRGFT
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMS
GVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLIQSGLDISPIITHHYSIDE
FQQGFDAMRSGQSGKVILNWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=24.8502994011976, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=24.6648793565684, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=23.8636363636364, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=23.7333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI71743840, Length=351, Percent_Identity=24.2165242165242, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=351, Percent_Identity=24.2165242165242, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=24.2857142857143, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501939, Length=344, Percent_Identity=24.1279069767442, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=23.1197771587744, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI71565154, Length=355, Percent_Identity=24.7887323943662, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=88.2697947214076, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=31.4199395770393, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=29.0055248618785, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=29.080118694362, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=29.1291291291291, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082125, Length=330, Percent_Identity=30.6060606060606, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.8221574344023, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=25.8566978193146, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786825, Length=396, Percent_Identity=27.5252525252525, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=29.9625468164794, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=26.4705882352941, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786518, Length=282, Percent_Identity=25.177304964539, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=30.4477611940298, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=336, Percent_Identity=30.0595238095238, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71988145, Length=202, Percent_Identity=32.6732673267327, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=127, Percent_Identity=34.6456692913386, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=24.8, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=271, Percent_Identity=26.5682656826568, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=24.1847826086957, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=24.198250728863, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=27.4509803921569, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=27.1241830065359, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=295, Percent_Identity=26.4406779661017, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=275, Percent_Identity=28.7272727272727, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=26.3586956521739, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=324, Percent_Identity=28.3950617283951, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=332, Percent_Identity=28.3132530120482, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=28.9634146341463, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=254, Percent_Identity=27.1653543307087, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=260, Percent_Identity=29.6153846153846, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=267, Percent_Identity=28.0898876404494, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=27.2455089820359, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17737895, Length=358, Percent_Identity=26.2569832402235, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221457811, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551930, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37237; Mature: 37237

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMV
CCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGMGQEVRGFTIGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGA
ECHHHHHHHHCCCCHHCCEEECCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
GVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LIQSGLDISPIITHHYSIDEFQQGFDAMRSGQSGKVILNWD
HHHCCCCCCCHHEECCCHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMV
CCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGMGQEVRGFTIGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGA
ECHHHHHHHHCCCCHHCCEEECCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
GVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LIQSGLDISPIITHHYSIDEFQQGFDAMRSGQSGKVILNWD
HHHCCCCCCCHHEECCCHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA