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The map label for this gene is hemF [H]

Identifier: 157959868

GI number: 157959868

Start: 41250

End: 42164

Strand: Direct

Name: hemF [H]

Synonym: Spea_0038

Alternate gene names: 157959868

Gene position: 41250-42164 (Clockwise)

Preceding gene: 157959867

Following gene: 157959870

Centisome position: 0.8

GC content: 49.4

Gene sequence:

>915_bases
ATGAGCACACCCGATTCAACACTAGTAAAAGCTTTCTTACTCGATCTTCAAAATCGAATTTGTAATGGACTCGAAGCATT
GGATGGCGCTGCGCAATTTGCTGAAGACTCTTGGAAGCGCGAAGAAGGCGGCGGTGGCCAAAGCCGTGTGTTGACTGGCG
GTGCTGTATTTGAACAAGCCGGGGTAAACTTTTCCCACGTGATGGGCGCTTCAATGCCTGCATCGGCAACGGCGCATCGT
CCAGAGCTTGCGGGTCGCAGTTTCGAAGCCATGGGAGTGTCGTTAGTTATTCACCCTAAAAATCCTCACATTCCAACGAC
TCATGCCAATGTGCGTTTCTTTATCGCCCATAAAGAAGGGGCCGATCCAGTCTGGTGGTTTGGTGGTGGCTTTGACTTAA
CTCCATACTATCCGTATTTAGAAGATGTGGTGGAGTGGCATCAGAGCGCCAAATCTTTATGTGAGCCATTTGGTGAAGAG
GTTTACCCTAAGTATAAGCAGTGGTGTGATGAATACTTCTGGTTACCGCATCGTAATGAGACGCGTGGCGTTGGCGGACT
CTTCTTCGATGATCTCAATAAGCAGGGCTTCGAACAGAGTTTTGCTTTTATGCAGGCGGTAGGTAATGGCTTCTTAACGG
CGTACGCCCCTATCGTTGAGCGTCGTAGAGATACTGAATATGGCGAGCATGAACGCCAGTTCCAACTATATCGTCGTGGG
CGCTATGTTGAGTTTAATTTGGTTTATGATCGTGGCACGCTATTCGGTCTGCAAACTGGTGGGCGTACAGAGTCGATACT
GATGTCTATGCCGCCACTCGTGCGCTGGGAGTATGCCTATACACCAGAAGCGGGTGGTCCAGAGGCGCAGCTTTATAGTG
ATTACCTAAAGCCCCGAGACTGGTTAAACCTTTAA

Upstream 100 bases:

>100_bases
GGGTGAGCTGGGTAGCCAGGCCTCACCATCTACGATTATCGATGCCAGAAGTGGAACCGTTATAAGAGAAGGTTAATCAG
CCTCTATAAAAAGGAATAAT

Downstream 100 bases:

>100_bases
CGTTTTTTATAACGAGCATAGCCATACCGACGAGACCAATAATGTGTTTAAACGTTATTGGTTTCGCATATGGTCCGCTA
GGGTTGCAATTGCACTATAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSTPDSTLVKAFLLDLQNRICNGLEALDGAAQFAEDSWKREEGGGGQSRVLTGGAVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPKNPHIPTTHANVRFFIAHKEGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGEE
VYPKYKQWCDEYFWLPHRNETRGVGGLFFDDLNKQGFEQSFAFMQAVGNGFLTAYAPIVERRRDTEYGEHERQFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGGPEAQLYSDYLKPRDWLNL

Sequences:

>Translated_304_residues
MSTPDSTLVKAFLLDLQNRICNGLEALDGAAQFAEDSWKREEGGGGQSRVLTGGAVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPKNPHIPTTHANVRFFIAHKEGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGEE
VYPKYKQWCDEYFWLPHRNETRGVGGLFFDDLNKQGFEQSFAFMQAVGNGFLTAYAPIVERRRDTEYGEHERQFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGGPEAQLYSDYLKPRDWLNL
>Mature_303_residues
STPDSTLVKAFLLDLQNRICNGLEALDGAAQFAEDSWKREEGGGGQSRVLTGGAVFEQAGVNFSHVMGASMPASATAHRP
ELAGRSFEAMGVSLVIHPKNPHIPTTHANVRFFIAHKEGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGEEV
YPKYKQWCDEYFWLPHRNETRGVGGLFFDDLNKQGFEQSFAFMQAVGNGFLTAYAPIVERRRDTEYGEHERQFQLYRRGR
YVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGGPEAQLYSDYLKPRDWLNL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=305, Percent_Identity=45.5737704918033, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=73.5785953177257, Blast_Score=464, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6320249, Length=319, Percent_Identity=43.8871473354232, Blast_Score=265, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=46.6887417218543, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34478; Mature: 34347

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPDSTLVKAFLLDLQNRICNGLEALDGAAQFAEDSWKREEGGGGQSRVLTGGAVFEQA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHH
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPKNPHIPTTHANVRFFIAHKEG
CCCHHHHHCCCCCCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGEEVYPKYKQWCDEYFWLPHRNE
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TRGVGGLFFDDLNKQGFEQSFAFMQAVGNGFLTAYAPIVERRRDTEYGEHERQFQLYRRG
CCCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGGPEAQLYSDYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHH
WLNL
HCCC
>Mature Secondary Structure 
STPDSTLVKAFLLDLQNRICNGLEALDGAAQFAEDSWKREEGGGGQSRVLTGGAVFEQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHH
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPKNPHIPTTHANVRFFIAHKEG
CCCHHHHHCCCCCCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGEEVYPKYKQWCDEYFWLPHRNE
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TRGVGGLFFDDLNKQGFEQSFAFMQAVGNGFLTAYAPIVERRRDTEYGEHERQFQLYRRG
CCCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGGPEAQLYSDYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHH
WLNL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA