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The map label for this gene is gltA [H]

Identifier: 157826319

GI number: 157826319

Start: 1172942

End: 1174249

Strand: Reverse

Name: gltA [H]

Synonym: A1C_06540

Alternate gene names: 157826319

Gene position: 1174249-1172942 (Counterclockwise)

Preceding gene: 157826320

Following gene: 157826318

Centisome position: 95.39

GC content: 36.16

Gene sequence:

>1308_bases
ATGACCAATGACAATGATTCTGATTCAGAATTTGCCGAATTAAAAATCAGAGGAAAAATATTTCAATTACCTATACTTAA
AGCAAGTATAGGTGAGGATGTAATCGACATAAGCAGGGTATCTGCGGAAGTCAATTGTTTTACTTATGACCCGGGTTTTA
TGTCTACTGCTTCTTGTAAGTCTACTATCACTTATATAGACGGTGATAAAGGAATCTTGCGGCATCGAGGATATAATATT
AAAGATTTAGCCGAGAAGAGCGATTTTTTGGAAGTGGCATATTTGCTAATCTATGGAGAATTACCAAGCATCGAGCAGTA
TAATAATTTCACTAAACAGGTTGCTCATCATTCATTAGTGAATGAAAGATTACACTATTTATTTCAAACCTTTTGTAGCT
CTTCTCATCCTATGGCTATTATGCTTGCGGCTATTGGTTCTCTGTCGGCATTTTATCCTGATTTACTGAATTTTAAAGAA
GCAGACTACGAACTTACCGCTATTAGAATGATTGCTAAGATACCAACTATCGCCGCAATGTCTTATAAATATTCTATAGG
ACAACCGTTTGTTTATCCTGATAATTCGTTAGATTTTACTGAAAATTTTCTGCATATGATGTTTGCAACGCCTTGTACAA
AATACAAAGTAAATCCAATAATAAAAAATGCGCTTAATAAGATATTTATCCTACATGCAGACCATGAGCAGAATGCTTCT
ACTTCAACAGTCCGAATAGCTGGTTCATCTGGAGCTAATGCTTTTGCGTGTATTAGCACTGGTATTGCATCACTTTGGGG
ACCTGCTCACGGCGGAGCTAATGAAGCGGTAATAAACATGCTTAAAGAAATCGGTAGTTCTGAGAATATACCTAAATATA
TAGCTAAAGCTAAGGATAAAAGTGATCCGTTTAGGTTAATGGGTTTCGGTCATCGTGTATATAAAAACTATGACCCACGT
GCCTCAGTACTTAAAGAAACGTGCAAAGAAGTATTAAAGGAACTTGGGCAGCTAGAAAATAATCCACTTTTACAAATAGC
AATAGAACTTGAAGCTATCGCTCTTAAAGATGAATATTTTATTGAGAGAAAATTATATCCAAATGTTGATTTTTATTCAG
GTATTATCTATAAAGCTATGGGTATACCGTCGCAAATGTTCACGGTACTTTTTGCAATAGCAAGAACCGTAGGCTGGATG
GCACAATGGAAAGAAATGCACGAAGACCCTGGACAAAAAATCAGCAGACCTAGACAGCTTTATACCGGTTATGTACATAG
AGAGTATACGGGTATCGGGGAAAGGTAA

Upstream 100 bases:

>100_bases
AATATAGAAAATTTTTAAAGCCTCATAAATACTAATTCATTTCTAATTTCATTAAATTAGGGTTATATTTACTGATGTAT
AAAAATAGGGTATATCCATT

Downstream 100 bases:

>100_bases
ACATTATCGTGAGCGGGTATTGCGTTGTGTGGACACCAAATCCGTCATTGCGAGGAGCCATAGGCGACGTGGCAATCTAG
AAAATAATTTAAAAAATAAA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTNDNDSDSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCKSTITYIDGDKGILRHRGYNI
KDLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLVNERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKE
ADYELTAIRMIAKIPTIAAMSYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNAS
TSTVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDKSDPFRLMGFGHRVYKNYDPR
ASVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYFIERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWM
AQWKEMHEDPGQKISRPRQLYTGYVHREYTGIGER

Sequences:

>Translated_435_residues
MTNDNDSDSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCKSTITYIDGDKGILRHRGYNI
KDLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLVNERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKE
ADYELTAIRMIAKIPTIAAMSYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNAS
TSTVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDKSDPFRLMGFGHRVYKNYDPR
ASVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYFIERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWM
AQWKEMHEDPGQKISRPRQLYTGYVHREYTGIGER
>Mature_434_residues
TNDNDSDSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCKSTITYIDGDKGILRHRGYNIK
DLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLVNERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKEA
DYELTAIRMIAKIPTIAAMSYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNAST
STVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDKSDPFRLMGFGHRVYKNYDPRA
SVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYFIERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWMA
QWKEMHEDPGQKISRPRQLYTGYVHREYTGIGER

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=393, Percent_Identity=27.735368956743, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1786939, Length=420, Percent_Identity=61.9047619047619, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1786527, Length=364, Percent_Identity=30.4945054945055, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17555174, Length=396, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324328, Length=388, Percent_Identity=26.5463917525773, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319850, Length=390, Percent_Identity=25.1282051282051, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24640126, Length=403, Percent_Identity=28.0397022332506, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640124, Length=403, Percent_Identity=28.0397022332506, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356863, Length=390, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48976; Mature: 48844

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDNDSDSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCK
CCCCCCCCCCEEEEEEECEEEEECCHHHHCCCHHHHHHHHCEEEEEEEECCCCCCCCCCC
STITYIDGDKGILRHRGYNIKDLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLV
CEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKEADYELTAIRMIAKIPTIAAM
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHE
SYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNAS
EEEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHCEEEEEECCCCCCCC
TSTVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDK
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCC
SDPFRLMGFGHRVYKNYDPRASVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYF
CCCCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECHHHH
IERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWMAQWKEMHEDPGQKISRPRQL
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHH
YTGYVHREYTGIGER
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
TNDNDSDSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCK
CCCCCCCCCEEEEEEECEEEEECCHHHHCCCHHHHHHHHCEEEEEEEECCCCCCCCCCC
STITYIDGDKGILRHRGYNIKDLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLV
CEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKEADYELTAIRMIAKIPTIAAM
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHE
SYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNAS
EEEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHCEEEEEECCCCCCCC
TSTVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDK
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCC
SDPFRLMGFGHRVYKNYDPRASVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYF
CCCCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECHHHH
IERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWMAQWKEMHEDPGQKISRPRQL
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHH
YTGYVHREYTGIGER
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112124; 9823893; 7557459 [H]