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The map label for this gene is lpd [H]

Identifier: 157826261

GI number: 157826261

Start: 1115997

End: 1117376

Strand: Reverse

Name: lpd [H]

Synonym: A1C_06210

Alternate gene names: 157826261

Gene position: 1117376-1115997 (Counterclockwise)

Preceding gene: 157826262

Following gene: 157826260

Centisome position: 90.77

GC content: 35.94

Gene sequence:

>1380_bases
ATGGAACAATATGATGTAGCCGTCATAGGCGGTGGTCCCAGTGGATATGTTGCAGCAATTAGAGCGGCACAATTAAGGAA
AAAAGTTGTATTAATAGAAAAAGAACATTTGGGAGGGGTATGTCTTAATTGGGGGTGTATACCGACTAAATCCCTGCTTA
AGTCTGCTGAGGTTTTTGAATATACAAAGCACGCTAAAGATTATGGAATTGATTCTGAAGGTGCTGAAATCAATATTAAG
AAAATAGTTGAGCGTTCAAGAGAGATTTCAAATAAGCTTGCAGGTGGCGTTAAGTTACTGTTGAAAAAAAATAAAGTTAC
CGTGATAGACGGAGTAGCAAGTCTTGCAGGAAATAAGGTAGTAAATATCAATAATAAATCTACAGTAAAAGCAGAAAATA
TTATTATAGCTACCGGAGCAAGATCTAGGGTGTTAAAAGGTTTTGAGCCTGATAGCAAGCAAATATGGACTTCAAAAGAA
GCTATGATACCGCGTCATGTGCCGAAATCTATGATTATTGTTGGTTCAGGTGCAATAGGTATAGAATTTGCTTCATTTTA
TAATAGTATTGGTGTGGATGTTACCGTAATTGAGGCACATAATAGAATATTACCTGCTGAAGATACGGAAATTTCCGGAA
TCGCTCATAAGAATTTTGAGAAAAAGGGAATAAAAATTATTACAAATGCTAAATTAATTAAGCAAACAAAATCAAAAGAT
AAGATAGAAGTGGAGCTAGAGTTATCCAGTAAAACACAAAAATTACAAGCTGAAATCTTACTTATGGCAGTAGGTATTAC
TGCAAATACAGAAAGTTTAGGACTAGAGAAAACCAAAGTTAAAGTAGAAAATGGTTATATAGTTACTAACGGATTAATGC
AAACTGCAGAACTAGGAATTTATGCTATAGGCGATGTAGCAGGAGTGCCTTGTTTAGCTCATAAAGCAAGCCATGAAGGT
ATTATTGCAGCAGAAAGCATAGCGGGCTTAAAACCCTATGCTATCAATAAGCATAATATACCGGGTTGCACTTATTCTTC
GCCGCAAATAGCAAGCGTCGGACTTACAGAAGAAGCAGCAAAAGCTTTGGGTTATGAATTAAAAATCGGTAAGTTTCCTT
TTATGGCTAATGGTAAGGCTTTAGTAATTGGTGATAGCGATGGCTTAATTAAAACTATATTTGATGCTAAGACTGGTGAG
TTGCTCGGTGCTCATATGATAGGCTTGGAAGTAACAGAATTAATACAAGGATATGTGGTTTCAAAAAATTTAGAAGCAAC
AGAGTTGGATTTAATTAATACTATCTTCCCACATCCGACTTTATCGGAAATGATGCACGAGTCAGTACTCGCTGCTTATG
ATAGGGTAGTACATGTATGA

Upstream 100 bases:

>100_bases
TACTTGTAATCCCACGACTTGATCGCGGGATCAAAAAAAATCAAAATCTAGATCCCGTGATCAAGTTGCGGGATTACAAT
ATAAACAAAACAAAAATAAA

Downstream 100 bases:

>100_bases
ACAAAGATAATTTAATCAAGAATTATGCAGTGGCGTTATTTAATAATGCTGTGGTTGATAACATACAAGATAAAATCTTT
GAAGAAATTACCGCTATAAA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MEQYDVAVIGGGPSGYVAAIRAAQLRKKVVLIEKEHLGGVCLNWGCIPTKSLLKSAEVFEYTKHAKDYGIDSEGAEINIK
KIVERSREISNKLAGGVKLLLKKNKVTVIDGVASLAGNKVVNINNKSTVKAENIIIATGARSRVLKGFEPDSKQIWTSKE
AMIPRHVPKSMIIVGSGAIGIEFASFYNSIGVDVTVIEAHNRILPAEDTEISGIAHKNFEKKGIKIITNAKLIKQTKSKD
KIEVELELSSKTQKLQAEILLMAVGITANTESLGLEKTKVKVENGYIVTNGLMQTAELGIYAIGDVAGVPCLAHKASHEG
IIAAESIAGLKPYAINKHNIPGCTYSSPQIASVGLTEEAAKALGYELKIGKFPFMANGKALVIGDSDGLIKTIFDAKTGE
LLGAHMIGLEVTELIQGYVVSKNLEATELDLINTIFPHPTLSEMMHESVLAAYDRVVHV

Sequences:

>Translated_459_residues
MEQYDVAVIGGGPSGYVAAIRAAQLRKKVVLIEKEHLGGVCLNWGCIPTKSLLKSAEVFEYTKHAKDYGIDSEGAEINIK
KIVERSREISNKLAGGVKLLLKKNKVTVIDGVASLAGNKVVNINNKSTVKAENIIIATGARSRVLKGFEPDSKQIWTSKE
AMIPRHVPKSMIIVGSGAIGIEFASFYNSIGVDVTVIEAHNRILPAEDTEISGIAHKNFEKKGIKIITNAKLIKQTKSKD
KIEVELELSSKTQKLQAEILLMAVGITANTESLGLEKTKVKVENGYIVTNGLMQTAELGIYAIGDVAGVPCLAHKASHEG
IIAAESIAGLKPYAINKHNIPGCTYSSPQIASVGLTEEAAKALGYELKIGKFPFMANGKALVIGDSDGLIKTIFDAKTGE
LLGAHMIGLEVTELIQGYVVSKNLEATELDLINTIFPHPTLSEMMHESVLAAYDRVVHV
>Mature_459_residues
MEQYDVAVIGGGPSGYVAAIRAAQLRKKVVLIEKEHLGGVCLNWGCIPTKSLLKSAEVFEYTKHAKDYGIDSEGAEINIK
KIVERSREISNKLAGGVKLLLKKNKVTVIDGVASLAGNKVVNINNKSTVKAENIIIATGARSRVLKGFEPDSKQIWTSKE
AMIPRHVPKSMIIVGSGAIGIEFASFYNSIGVDVTVIEAHNRILPAEDTEISGIAHKNFEKKGIKIITNAKLIKQTKSKD
KIEVELELSSKTQKLQAEILLMAVGITANTESLGLEKTKVKVENGYIVTNGLMQTAELGIYAIGDVAGVPCLAHKASHEG
IIAAESIAGLKPYAINKHNIPGCTYSSPQIASVGLTEEAAKALGYELKIGKFPFMANGKALVIGDSDGLIKTIFDAKTGE
LLGAHMIGLEVTELIQGYVVSKNLEATELDLINTIFPHPTLSEMMHESVLAAYDRVVHV

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=37.9609544468547, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=29.4759825327511, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=25.8771929824561, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI33519430, Length=469, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519428, Length=469, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519426, Length=469, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277065, Length=469, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277071, Length=469, Percent_Identity=26.865671641791, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=25, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI291045268, Length=456, Percent_Identity=24.1228070175439, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=35.3711790393013, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=28.8793103448276, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=28.5403050108932, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=29.4252873563218, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1787352, Length=316, Percent_Identity=24.6835443037975, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=39.0086206896552, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71983429, Length=435, Percent_Identity=26.6666666666667, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=435, Percent_Identity=26.6666666666667, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17557007, Length=484, Percent_Identity=25.2066115702479, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=25.987525987526, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=37.8947368421053, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=27.4261603375527, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=26.4516129032258, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=37.6623376623377, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=25.6900212314225, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=25.6900212314225, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=25.6900212314225, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737741, Length=467, Percent_Identity=22.9122055674518, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49331; Mature: 49331

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQYDVAVIGGGPSGYVAAIRAAQLRKKVVLIEKEHLGGVCLNWGCIPTKSLLKSAEVFE
CCCEEEEEECCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
YTKHAKDYGIDSEGAEINIKKIVERSREISNKLAGGVKLLLKKNKVTVIDGVASLAGNKV
HHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECHHHHCCCEE
VNINNKSTVKAENIIIATGARSRVLKGFEPDSKQIWTSKEAMIPRHVPKSMIIVGSGAIG
EEECCCCEEEECEEEEECCCHHHHHCCCCCCCCCEECCCCCCCCCCCCCEEEEEECCCCH
IEFASFYNSIGVDVTVIEAHNRILPAEDTEISGIAHKNFEKKGIKIITNAKLIKQTKSKD
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHCCCCC
KIEVELELSSKTQKLQAEILLMAVGITANTESLGLEKTKVKVENGYIVTNGLMQTAELGI
EEEEEEEECCCHHHHHEEEEEEEEEEECCCHHCCCEEEEEEEECCEEEECCCHHHHHCCE
YAIGDVAGVPCLAHKASHEGIIAAESIAGLKPYAINKHNIPGCTYSSPQIASVGLTEEAA
EEECCCCCCCHHHHCCCCCCEEEEHHHCCCCCEECCCCCCCCCCCCCCCEEECCCCHHHH
KALGYELKIGKFPFMANGKALVIGDSDGLIKTIFDAKTGELLGAHMIGLEVTELIQGYVV
HHCCEEEEECCCCEEECCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCEEE
SKNLEATELDLINTIFPHPTLSEMMHESVLAAYDRVVHV
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQYDVAVIGGGPSGYVAAIRAAQLRKKVVLIEKEHLGGVCLNWGCIPTKSLLKSAEVFE
CCCEEEEEECCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
YTKHAKDYGIDSEGAEINIKKIVERSREISNKLAGGVKLLLKKNKVTVIDGVASLAGNKV
HHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECHHHHCCCEE
VNINNKSTVKAENIIIATGARSRVLKGFEPDSKQIWTSKEAMIPRHVPKSMIIVGSGAIG
EEECCCCEEEECEEEEECCCHHHHHCCCCCCCCCEECCCCCCCCCCCCCEEEEEECCCCH
IEFASFYNSIGVDVTVIEAHNRILPAEDTEISGIAHKNFEKKGIKIITNAKLIKQTKSKD
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHCCCCC
KIEVELELSSKTQKLQAEILLMAVGITANTESLGLEKTKVKVENGYIVTNGLMQTAELGI
EEEEEEEECCCHHHHHEEEEEEEEEEECCCHHCCCEEEEEEEECCEEEECCCHHHHHCCE
YAIGDVAGVPCLAHKASHEGIIAAESIAGLKPYAINKHNIPGCTYSSPQIASVGLTEEAA
EEECCCCCCCHHHHCCCCCCEEEEHHHCCCCCEECCCCCCCCCCCCCCCEEECCCCHHHH
KALGYELKIGKFPFMANGKALVIGDSDGLIKTIFDAKTGELLGAHMIGLEVTELIQGYVV
HHCCEEEEECCCCEEECCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCEEE
SKNLEATELDLINTIFPHPTLSEMMHESVLAAYDRVVHV
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]