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The map label for this gene is gmk [H]

Identifier: 157826218

GI number: 157826218

Start: 1060517

End: 1061095

Strand: Reverse

Name: gmk [H]

Synonym: A1C_05985

Alternate gene names: 157826218

Gene position: 1061095-1060517 (Counterclockwise)

Preceding gene: 157826219

Following gene: 157826217

Centisome position: 86.19

GC content: 30.74

Gene sequence:

>579_bases
ATGACAATAAAAAATAAAGGACTGATTATAATTTTATCTTCTCCTTCAGGTACTGGTAAGTCAAGTTTAGCTAAAGCATT
ATTGAAAATAGATAATAATTTACGTTTATCTATTTCGGCAACTACAAGAAAACCACGTTTAGGAGAAGTAGATGGCATAC
ACTATTACTTTAAGACCAGTCTAGAATTTAAAGAATTAGTTAAGCAGAATAAATTTTTTGAATATGCTAAAATATACGAT
AATTATTACGGTACGCCTAAAGAATATGTCGAAATGTTATTAAATCAAGGCTTAGACGTTTTGTTTGATATTGATTGGCA
AGGAGCAAAGAGCATTAAGAAAAATGCTACTAATGTTGTTGCTATATTTATATTGCCTCCTAGTATTGAAATACTGGAAC
AACGCTTAAGGAAGAGAGCTACCGATAATGAAGAAGCAATAAAATTACGTATGAAGTCGGCACAAAACGAAATGTCACAT
GCTAATGAGTACGATTATGTGATTACTAACGATGATTTTAGCCATACTCTTAAAAAAATACATGCTATTATAGTTGCAGA
ACGGGAAAAAGCTTTTTGA

Upstream 100 bases:

>100_bases
TCACCTGTACTTTATCTACTGCTTTCGCAGGCTTGCATTTAAAGTCATCTTGTCTGAATCTTTCTGAAATATGCTGTACC
TACGAAATAAAATATAAAAT

Downstream 100 bases:

>100_bases
CTTTATCACTTTTCCTTTTTATACTGAAAATTGGAAGCTTAACTGGTGAATTTCAAAAATTGGCTACGTCGTTCTGCAAG
ATCTCCGGTGCTGAATGTTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MTIKNKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRKPRLGEVDGIHYYFKTSLEFKELVKQNKFFEYAKIYD
NYYGTPKEYVEMLLNQGLDVLFDIDWQGAKSIKKNATNVVAIFILPPSIEILEQRLRKRATDNEEAIKLRMKSAQNEMSH
ANEYDYVITNDDFSHTLKKIHAIIVAEREKAF

Sequences:

>Translated_192_residues
MTIKNKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRKPRLGEVDGIHYYFKTSLEFKELVKQNKFFEYAKIYD
NYYGTPKEYVEMLLNQGLDVLFDIDWQGAKSIKKNATNVVAIFILPPSIEILEQRLRKRATDNEEAIKLRMKSAQNEMSH
ANEYDYVITNDDFSHTLKKIHAIIVAEREKAF
>Mature_191_residues
TIKNKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRKPRLGEVDGIHYYFKTSLEFKELVKQNKFFEYAKIYDN
YYGTPKEYVEMLLNQGLDVLFDIDWQGAKSIKKNATNVVAIFILPPSIEILEQRLRKRATDNEEAIKLRMKSAQNEMSHA
NEYDYVITNDDFSHTLKKIHAIIVAEREKAF

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RPE1 insert domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=186, Percent_Identity=36.5591397849462, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI4504221, Length=186, Percent_Identity=36.5591397849462, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI226874831, Length=186, Percent_Identity=36.5591397849462, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI119943106, Length=148, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=164, Percent_Identity=32.3170731707317, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=23.7373737373737, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI119943108, Length=149, Percent_Identity=30.8724832214765, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI261862237, Length=149, Percent_Identity=30.8724832214765, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=185, Percent_Identity=50.2702702702703, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI193203132, Length=187, Percent_Identity=37.9679144385027, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=187, Percent_Identity=37.9679144385027, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=28.021978021978, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=177, Percent_Identity=24.8587570621469, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=177, Percent_Identity=24.8587570621469, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=146, Percent_Identity=28.0821917808219, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.0765027322404, Blast_Score=143, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.3626373626374, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- InterPro:   IPR005728 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22007; Mature: 21875

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKNKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRKPRLGEVDGIHYYFKTS
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEECC
LEFKELVKQNKFFEYAKIYDNYYGTPKEYVEMLLNQGLDVLFDIDWQGAKSIKKNATNVV
CHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEE
AIFILPPSIEILEQRLRKRATDNEEAIKLRMKSAQNEMSHANEYDYVITNDDFSHTLKKI
EEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
HAIIVAEREKAF
HHHHEECCCCCC
>Mature Secondary Structure 
TIKNKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRKPRLGEVDGIHYYFKTS
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEECC
LEFKELVKQNKFFEYAKIYDNYYGTPKEYVEMLLNQGLDVLFDIDWQGAKSIKKNATNVV
CHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEE
AIFILPPSIEILEQRLRKRATDNEEAIKLRMKSAQNEMSHANEYDYVITNDDFSHTLKKI
EEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
HAIIVAEREKAF
HHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]