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The map label for this gene is fabF [H]

Identifier: 157826212

GI number: 157826212

Start: 1055099

End: 1056379

Strand: Direct

Name: fabF [H]

Synonym: A1C_05945

Alternate gene names: 157826212

Gene position: 1055099-1056379 (Clockwise)

Preceding gene: 157826211

Following gene: 157826213

Centisome position: 85.71

GC content: 39.42

Gene sequence:

>1281_bases
ATGTCGAATCAAAGAGTAAATAAAAGAGTAGTTATTACCGGACTTGGACTTGTTACTCCTGTTGGGCTTAATGTTAGCTC
ATCTTGGAAAAATATTGTAAATGGGGTAAGCGGTATAAAAACTATTACGGAATTTGATGCTTCTAAACTTGCGTGTAAAA
TTGCTGGACTTATAGATTACTCTGAGAAAGATGGATTTAAACTTGAAAATTTCACGCAAGCAGATAACGTTAATAGACTA
AGTAAAATGGATAAATTTATCCATTACGGAGTAGCAGCCGCAACCGAAGCAGTTGAAGATAGCGGCTGGTTACCCGAAAA
TGAAGAATCTCGTGATAGAACCGGCTTGATATTAGGTTCAGGAATCGGCGGGCTTAAAATGATCGAAGATACCTCTATCA
AGCTTTATCAAGAAAATAATGGCAAAGTTAGTCCCTTCTTTATTCCTGCATCACTAATTAATCTTTTATCCGGTCTTGTG
TCTATAAAATACGGTTTTAGCGGTCCAAATCAAGCAGCAGTAACGGCTTGCTCTACAGGAGCACATGCTATAGGCGATGC
TATGCGTATGATAAAACACGGCTATGCAGACGTTATGGTCGCAGGCGGTGCAGAAGCTCCAGTTACACCTGTTGGAGTTG
CAGGTTTCGTTGCTGCTAGAGCATTATGTACTAAATATAACGATAATCCTGAAAAAGCCTCAAGACCTTGGGATAAAGAC
CGCAGCGGTTTTGTTATGGGTGAAGGAGCAGGCGTTGTAGTCTTGGAAGAATATGAGCATGCCTTAAATCGAGGGGCTAA
AATTTACGGTGAAGTTATAGGATACGGCTCTACAGGTGATGCGTACCATATGACAGCACCACATCCTGAAGGTAGAGGGG
CTTATAGAGCGATGAGAAATGCAATGCTAGATGCAGCTATCACCCCCAATATGATTGATTACATTAATGCACATGGCACT
TCTACTAATCTCGGTGATGAGATAGAATTAGCAGCCGTACAAAAATTATTTTTAGAAGCGAATCCTCAAATTTTAATGTC
TTCTACTAAATCATCAATAGGACATTTACTCGGTGCAGCAGGAAGCGTTGAGTTTATCTTTTCAGCTCTTGCAATTCGAG
ATCAGATTGCACCGCCAACTTTAAATTTAGATAACCCCATGGATGAGGTTAAGATAGATTTAGTAAAATTAAAAGCTAGA
GAAACTAAAATAGACTACGTGCTTTCTAATTCATTTGGATTCGGCGGTACTAATGCTAGTTTAGTAATTAAGAGAGTTTG
A

Upstream 100 bases:

>100_bases
ATGAAGCCACTAAAATTAAAACCGTATCCGATGTTATAACATATATCAAAGAACGCCAATCTTAATCTACATCAATTAAA
TCCCTAATAGATAATTAAAA

Downstream 100 bases:

>100_bases
TTCCTACACAGTCATTGCAAGAAACTAAAGGCGTTGTTGCATGGATCGGTTGATGTTATTCCAGCAAAAGCGTGAATCCA
GCGCAAGGCAAGATAAATCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVNGVSGIKTITEFDASKLACKIAGLIDYSEKDGFKLENFTQADNVNRL
SKMDKFIHYGVAAATEAVEDSGWLPENEESRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLV
SIKYGFSGPNQAAVTACSTGAHAIGDAMRMIKHGYADVMVAGGAEAPVTPVGVAGFVAARALCTKYNDNPEKASRPWDKD
RSGFVMGEGAGVVVLEEYEHALNRGAKIYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRNAMLDAAITPNMIDYINAHGT
STNLGDEIELAAVQKLFLEANPQILMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDNPMDEVKIDLVKLKAR
ETKIDYVLSNSFGFGGTNASLVIKRV

Sequences:

>Translated_426_residues
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVNGVSGIKTITEFDASKLACKIAGLIDYSEKDGFKLENFTQADNVNRL
SKMDKFIHYGVAAATEAVEDSGWLPENEESRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLV
SIKYGFSGPNQAAVTACSTGAHAIGDAMRMIKHGYADVMVAGGAEAPVTPVGVAGFVAARALCTKYNDNPEKASRPWDKD
RSGFVMGEGAGVVVLEEYEHALNRGAKIYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRNAMLDAAITPNMIDYINAHGT
STNLGDEIELAAVQKLFLEANPQILMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDNPMDEVKIDLVKLKAR
ETKIDYVLSNSFGFGGTNASLVIKRV
>Mature_425_residues
SNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVNGVSGIKTITEFDASKLACKIAGLIDYSEKDGFKLENFTQADNVNRLS
KMDKFIHYGVAAATEAVEDSGWLPENEESRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVS
IKYGFSGPNQAAVTACSTGAHAIGDAMRMIKHGYADVMVAGGAEAPVTPVGVAGFVAARALCTKYNDNPEKASRPWDKDR
SGFVMGEGAGVVVLEEYEHALNRGAKIYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRNAMLDAAITPNMIDYINAHGTS
TNLGDEIELAAVQKLFLEANPQILMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDNPMDEVKIDLVKLKARE
TKIDYVLSNSFGFGGTNASLVIKRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=47.2813238770686, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI223972627, Length=202, Percent_Identity=37.1287128712871, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=24.7113163972286, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1787337, Length=422, Percent_Identity=52.60663507109, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=426, Percent_Identity=38.2629107981221, Blast_Score=247, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=36.7924528301887, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=42.6923076923077, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=422, Percent_Identity=24.1706161137441, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=439, Percent_Identity=25.0569476082005, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=38.7527839643653, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=43.6194895591647, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI221330659, Length=435, Percent_Identity=22.9885057471264, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920632, Length=435, Percent_Identity=22.9885057471264, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=22.8971962616822, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45454; Mature: 45323

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVNGVSGIKTITEFDASKLACKIAGLIDY
CCCCCCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEC
SEKDGFKLENFTQADNVNRLSKMDKFIHYGVAAATEAVEDSGWLPENEESRDRTGLILGS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
GIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVSIKYGFSGPNQAAVTACSTG
CCCCCEEEECCEEEEEECCCCEECEEEEHHHHHHHHHHHHEEEECCCCCCCCEEEEECCC
AHAIGDAMRMIKHGYADVMVAGGAEAPVTPVGVAGFVAARALCTKYNDNPEKASRPWDKD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCC
RSGFVMGEGAGVVVLEEYEHALNRGAKIYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRN
CCCEEEECCCCEEEEHHHHHHHHCCCEEEEHHEECCCCCCEEEECCCCCCCCHHHHHHHH
AMLDAAITPNMIDYINAHGTSTNLGDEIELAAVQKLFLEANPQILMSSTKSSIGHLLGAA
HHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCC
GSVEFIFSALAIRDQIAPPTLNLDNPMDEVKIDLVKLKARETKIDYVLSNSFGFGGTNAS
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEEEEEEHHCCEEEEEEECCCCCCCCCCE
LVIKRV
EEEEEC
>Mature Secondary Structure 
SNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVNGVSGIKTITEFDASKLACKIAGLIDY
CCCCCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEC
SEKDGFKLENFTQADNVNRLSKMDKFIHYGVAAATEAVEDSGWLPENEESRDRTGLILGS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
GIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVSIKYGFSGPNQAAVTACSTG
CCCCCEEEECCEEEEEECCCCEECEEEEHHHHHHHHHHHHEEEECCCCCCCCEEEEECCC
AHAIGDAMRMIKHGYADVMVAGGAEAPVTPVGVAGFVAARALCTKYNDNPEKASRPWDKD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCC
RSGFVMGEGAGVVVLEEYEHALNRGAKIYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRN
CCCEEEECCCCEEEEHHHHHHHHCCCEEEEHHEECCCCCCEEEECCCCCCCCHHHHHHHH
AMLDAAITPNMIDYINAHGTSTNLGDEIELAAVQKLFLEANPQILMSSTKSSIGHLLGAA
HHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCC
GSVEFIFSALAIRDQIAPPTLNLDNPMDEVKIDLVKLKARETKIDYVLSNSFGFGGTNAS
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEEEEEEHHCCEEEEEEECCCCCCCCCCE
LVIKRV
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]