Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 157826177

GI number: 157826177

Start: 1022369

End: 1023631

Strand: Direct

Name: glyA [H]

Synonym: A1C_05770

Alternate gene names: 157826177

Gene position: 1022369-1023631 (Clockwise)

Preceding gene: 157826176

Following gene: 157826178

Centisome position: 83.05

GC content: 36.03

Gene sequence:

>1263_bases
ATGAATATTTTTAATAATAATTTGCATGAAACGGATAAAGAAATTAATGAAATAATAAAACATGAAAAGTTACGTCAAAG
TAGCGTAATCGAGCTTATTGCATCAGAGAATTTCGTAAGTCCCGCAGTACTTGAAGCTCAAGGGTCGATTCTGACTAATA
AATATGCAGAAGGGTATTCCGGTAAACGTTTTTATAACGGTTGTGAGGAAGTAGATAAAGCTGAAAATTTAGCTATAGAG
AGAGTAAAAAAATTATTTAACTGCAAATATGCAAATGTGCAACCTCATTCAGGCTCACAAGCAAATCAAGCTGTATATCT
TACTTTATTACAGCCGGGCGATACAATTCTTGGTATGTCATTAGATAGCGGTGGGCATCTAACGCACGGTGCATCCCCTA
ATATGTCCGGTAAATGGTTTAACGCCGTTTCTTATGGCGTAAATAAAAAAACTTATTTAATCGATTATGATGAGATTGAG
AGGTTAGCAGTTTTACATAAGCCAAAACTACTTATAGCTGGCTTTTCTGCTTATCCTCGTAATATTGATTTTACAAGATT
TAGAGAAATTGCGGATAAAGTCGGAGCATATTTCATGGCAGATATTGCTCATATTGCAGGGCTTGTTGCCACAGGTGAGC
ATCAAAGCCCTATTTCTTATGCTCATGTTGTTACCTCCACTACTCACAAAACGCTTAGGGGACCAAGGGGTGGTTTAGTC
TTATCTGACGATGAAGAGATAGGCAAAAAAATAAATTCTGCATTATTTCCAGGATTACAAGGTGGTCCGTTAATGCATAT
AGTCGCCGCAAAAGCAGTAGCTTTTTTAGAAAGCTTGCAGCCTGAATATAAAAGCTATATTAAGCAGATAATAAGTAACG
CTAAAGCTTTAGCAAGTAGCTTGCAAGAAAGAGGATATGATATATTAACAGGCGGAACAGATAATCATATTGTTTTAGTG
GATTTGCGTAAAAACGGAATTACCGGAAAGCTTGCTGCTAATTCTTTAGATAACGCAGGGATTACATGTAATAAGAATGC
TATCCCGTTTGATGAAACTTCGCCTTTTATCACTTCAGGTATTCGCCTTGGTACTCCCGCATGTACTACTAGAGGCTTTA
AAGAACAGGATTTCGTATCAGTCGGTCATATGGTAGCAGATATTTTAGATGGTCTAAAGAATAATAAAGATAATACTAAA
GCTGAACAGCAAGTGCTACATAAAGTAACAAAACTAATTAAATTATTTCCGTTTTATGACTAA

Upstream 100 bases:

>100_bases
CTAGAACATGGCATAATCATGGAAATAAGTTCAGGTTCAGAAATAGTAGATTGCACGAGTTGTATGAAAATGTAAAACCA
ATATAAATATGGGATAATTA

Downstream 100 bases:

>100_bases
TTTAAATAAAAAACCGGATTGGATAAAGGTTAAAGCTCCTAATTCTGCAGAGTATTATAATACAAAAGATTTAATAAAGA
ATCTGAGTTTAAATACTGTG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYSGKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMSLDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIE
RLAVLHKPKLLIAGFSAYPRNIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLV
LSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTK
AEQQVLHKVTKLIKLFPFYD

Sequences:

>Translated_420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYSGKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMSLDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIE
RLAVLHKPKLLIAGFSAYPRNIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLV
LSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTK
AEQQVLHKVTKLIKLFPFYD
>Mature_420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYSGKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMSLDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIE
RLAVLHKPKLLIAGFSAYPRNIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLV
LSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTK
AEQQVLHKVTKLIKLFPFYD

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=409, Percent_Identity=46.9437652811736, Blast_Score=355, Evalue=7e-98,
Organism=Homo sapiens, GI261862352, Length=409, Percent_Identity=46.9437652811736, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI261862350, Length=409, Percent_Identity=46.9437652811736, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI261862348, Length=409, Percent_Identity=46.9437652811736, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=48.3790523690773, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI261862346, Length=404, Percent_Identity=46.2871287128713, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI22547189, Length=387, Percent_Identity=45.4780361757106, Blast_Score=302, Evalue=4e-82,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=54.2168674698795, Blast_Score=443, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25144732, Length=409, Percent_Identity=48.1662591687042, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25144729, Length=409, Percent_Identity=48.1662591687042, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=399, Percent_Identity=45.3634085213033, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=429, Percent_Identity=40.5594405594406, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24640005, Length=404, Percent_Identity=49.7524752475247, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221329721, Length=404, Percent_Identity=49.7524752475247, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46042; Mature: 46042

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCCC
GKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIERLAVLHKPKLLIAGFSAYPR
ECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCEEEEECCCCCC
NIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
LSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASS
ECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LQERGYDILTGGTDNHIVLVDLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSG
HHHCCCEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHCC
IRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTKAEQQVLHKVTKLIKLFPFYD
EECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCCC
GKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIERLAVLHKPKLLIAGFSAYPR
ECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCEEEEECCCCCC
NIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
LSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASS
ECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LQERGYDILTGGTDNHIVLVDLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSG
HHHCCCEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHCC
IRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTKAEQQVLHKVTKLIKLFPFYD
EECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA