Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 157826138

GI number: 157826138

Start: 991492

End: 992469

Strand: Reverse

Name: lpxK

Synonym: A1C_05575

Alternate gene names: 157826138

Gene position: 992469-991492 (Counterclockwise)

Preceding gene: 157826139

Following gene: 157826137

Centisome position: 80.62

GC content: 29.14

Gene sequence:

>978_bases
ATGATCAAACTTTTATATCCTAAATTTTGGCAAAAGCGAAATATTATAGCTTATTTGCTTTTGCCTATAGGCCTGATATA
TAAATTTTTAGGCTATTTACGAGATAGTTTAGCGCGTCCTATTATGTTGCCTGCTAAAGTTATTTGTGTCGGTAATTGTA
GCGTAGGAGGTACGGGTAAGACACAGATAGTAATGTATCTAGCCAAATTACTGAGAGCTAAAAATGTAAGTTTTGTAATA
GTAACTAAGGCTTATGGTAGTAACCTTAAAAGTGCAACTACCATACATCCAGGACATACAGCATTAGAGGTAGGAGATGA
GGGAGTAATACTTGCAAAGTATGGAACAGTTATTGCTACTAAAAATATTAAAGAGATTTTACCATTAATTAATGAGCTTA
AACCTGATATAATAATAATTGATGATTTCCTACAAAATCCTTATTTTTATAAAGATTTTACTATAGTTTCAGTAGATAGC
CAAAGGCTTTTTGGCAATGGCTTTCTAATTCCTGCAGGGCCCTTAAGACAAGATCCAAATAAAGCCCTTGATGCAGCTGA
TTTAATTTTTTTAGTCAGTAGTACCAATGATAAAATACCGAATATTTTAACTCCTTATGTCAATAAAGTAATAAGTGCTC
AAATAGTTCCTTCAAATAATATAGATAAAACTAAAAATTATTTTGCTTTTAGTGGTATCGGTAATCCTGAGCGTTTCTTT
TCGACTTTAAAAAATTATGGACTGAATATAACCGGTTACAAAATTTTTCCTGATCATTATAATTATTTACAAGAAGATTT
GGAAAATTTATATTCGTTAGCTAAAGAGCATAATACTACCTTAATTACTACAAGAAAAGATCATATTAAGTTCAATGATT
TAAATAATAATATTGTCTGTTTAGATGTAGAACTATCTATAAACAACCATGATTTATTAAATGAAAAAATTTTTAAAAAA
GCTCAGATATTTAATTGA

Upstream 100 bases:

>100_bases
TGAAGTTATTGTTTATGGATCTCAGCCTACGCGGGAATGACATAGAGTAGGTTTATCGATCCATGCAATAACACAAATAT
TAACCTAATTTATATATAAC

Downstream 100 bases:

>100_bases
GTATTTTATCGTCGTTATATTCCTTAAAGTAATAGGAATATTCGGTGTAGATAAAGCAGCAGATATTTGTAGTTTTATAG
CAAGAAAAGTCGGTATATTA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIKLLYPKFWQKRNIIAYLLLPIGLIYKFLGYLRDSLARPIMLPAKVICVGNCSVGGTGKTQIVMYLAKLLRAKNVSFVI
VTKAYGSNLKSATTIHPGHTALEVGDEGVILAKYGTVIATKNIKEILPLINELKPDIIIIDDFLQNPYFYKDFTIVSVDS
QRLFGNGFLIPAGPLRQDPNKALDAADLIFLVSSTNDKIPNILTPYVNKVISAQIVPSNNIDKTKNYFAFSGIGNPERFF
STLKNYGLNITGYKIFPDHYNYLQEDLENLYSLAKEHNTTLITTRKDHIKFNDLNNNIVCLDVELSINNHDLLNEKIFKK
AQIFN

Sequences:

>Translated_325_residues
MIKLLYPKFWQKRNIIAYLLLPIGLIYKFLGYLRDSLARPIMLPAKVICVGNCSVGGTGKTQIVMYLAKLLRAKNVSFVI
VTKAYGSNLKSATTIHPGHTALEVGDEGVILAKYGTVIATKNIKEILPLINELKPDIIIIDDFLQNPYFYKDFTIVSVDS
QRLFGNGFLIPAGPLRQDPNKALDAADLIFLVSSTNDKIPNILTPYVNKVISAQIVPSNNIDKTKNYFAFSGIGNPERFF
STLKNYGLNITGYKIFPDHYNYLQEDLENLYSLAKEHNTTLITTRKDHIKFNDLNNNIVCLDVELSINNHDLLNEKIFKK
AQIFN
>Mature_325_residues
MIKLLYPKFWQKRNIIAYLLLPIGLIYKFLGYLRDSLARPIMLPAKVICVGNCSVGGTGKTQIVMYLAKLLRAKNVSFVI
VTKAYGSNLKSATTIHPGHTALEVGDEGVILAKYGTVIATKNIKEILPLINELKPDIIIIDDFLQNPYFYKDFTIVSVDS
QRLFGNGFLIPAGPLRQDPNKALDAADLIFLVSSTNDKIPNILTPYVNKVISAQIVPSNNIDKTKNYFAFSGIGNPERFF
STLKNYGLNITGYKIFPDHYNYLQEDLENLYSLAKEHNTTLITTRKDHIKFNDLNNNIVCLDVELSINNHDLLNEKIFKK
AQIFN

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=314, Percent_Identity=28.9808917197452, Blast_Score=128, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_RICAH (A8GPM5)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493858.1
- STRING:   A8GPM5
- GeneID:   5645071
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_05575
- NMPDR:   fig|293614.3.peg.1050
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   RAKA293614:A1C_05575-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36636; Mature: 36636

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLLYPKFWQKRNIIAYLLLPIGLIYKFLGYLRDSLARPIMLPAKVICVGNCSVGGTGK
CEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCH
TQIVMYLAKLLRAKNVSFVIVTKAYGSNLKSATTIHPGHTALEVGDEGVILAKYGTVIAT
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCEEEECCCCEEEEECCCEEEE
KNIKEILPLINELKPDIIIIDDFLQNPYFYKDFTIVSVDSQRLFGNGFLIPAGPLRQDPN
CCHHHHHHHHHHCCCCEEEEEHHHCCCEEEECEEEEEECCCEEECCCEEECCCCCCCCCC
KALDAADLIFLVSSTNDKIPNILTPYVNKVISAQIVPSNNIDKTKNYFAFSGIGNPERFF
HHHCCEEEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCCHHHHH
STLKNYGLNITGYKIFPDHYNYLQEDLENLYSLAKEHNTTLITTRKDHIKFNDLNNNIVC
HHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEEE
LDVELSINNHDLLNEKIFKKAQIFN
EEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKLLYPKFWQKRNIIAYLLLPIGLIYKFLGYLRDSLARPIMLPAKVICVGNCSVGGTGK
CEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCH
TQIVMYLAKLLRAKNVSFVIVTKAYGSNLKSATTIHPGHTALEVGDEGVILAKYGTVIAT
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCEEEECCCCEEEEECCCEEEE
KNIKEILPLINELKPDIIIIDDFLQNPYFYKDFTIVSVDSQRLFGNGFLIPAGPLRQDPN
CCHHHHHHHHHHCCCCEEEEEHHHCCCEEEECEEEEEECCCEEECCCEEECCCCCCCCCC
KALDAADLIFLVSSTNDKIPNILTPYVNKVISAQIVPSNNIDKTKNYFAFSGIGNPERFF
HHHCCEEEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCCHHHHH
STLKNYGLNITGYKIFPDHYNYLQEDLENLYSLAKEHNTTLITTRKDHIKFNDLNNNIVC
HHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEEE
LDVELSINNHDLLNEKIFKKAQIFN
EEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA