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The map label for this gene is fumC [H]

Identifier: 157826068

GI number: 157826068

Start: 917053

End: 918444

Strand: Direct

Name: fumC [H]

Synonym: A1C_05130

Alternate gene names: 157826068

Gene position: 917053-918444 (Clockwise)

Preceding gene: 157826067

Following gene: 157826069

Centisome position: 74.49

GC content: 37.28

Gene sequence:

>1392_bases
ATGAAAAATTACAGAACCGAAAGCGATTCTTTTGGAGAAATTCAAATAGAAGAAAAATTTTATTGGGGAGCTCAAACTCA
AAGATCTTTAGAAAATTTTAAAATAGGCAAACAAAAAATGCCTGAAATTTTAATTCGTGCTCTTGCTATTTTAAAAAAAT
GTGCAGCACAGGTTAATTATGAGTTTGGTGATTTAGAAGCTAAAATAGCTACAAGTATCGATAAAGCTACAGATAGAATC
TTAGAAGGCGAATTTGAGGATAATTTTCCTTTAGTAGTTTGGCAAACGGGTTCGGGTACGCAAACAAACATGAATATGAA
CGAGGTTATTGCATCTATTGCTAATGAAGAATTAACAAGCAAGAAAGGCGGCAAATCTCCAGTACATCCTAACGACCATG
TTAATAAAGGACAATCATCCAACGACTCTTTTCCAACCGCTATGCATATAGCAACCGTACTTGCAACTAAACAGCAACTT
ATACCGGCTTTGAATAATTTACTTACAGCTTTGCAAGACAAGTCAAAAGATTGGGGTAAAATCATAAAAATAGGACGCAC
CCACTTGCAGGACGCAACTCCTTTAACTCTTAAACAGGAATTCTCCGGATATATTACACAAATAGAGTATGCTTTAGAAC
GCATAGGAGATGCACTAAAAAAAGTTTATCTACTTGCTCAAGGTGGAACGGCAGTCGGCACAGGTATTAACTCAAAAATA
GGCTTTGATATCAGATTTGCTGAGAAAGTGGCAGAGTTTACTAAACAACCCTTCAAGACGGCTCCTAATAAATTTGAAAG
TCTAGCTGCCCACGACGCACTAGTAGAATTTTCAGGAACTCTTAATACTATAGCAGTTAGCTTAATGAAAATAGCACATG
ATATAAGGTTACTCGGGTCAGGTCCAAGATGCGGTCTTGGTGAGCTGCATTTACCAGAAAACGAACCCGGTTCTTCGATT
ATGCCCGGTAAAGTAAACCCTACCCAAGTCGAAGCTTTAACAATGGTGTGCAGTCAGGTGATGGGAAATCATGTTACGGT
TACTATTGCCGGCTCTAACGGACATCTTGAACTTAACGTATTTAAACCTGTAATAATATACAATATCCTACAATCTATAG
AGCTGTTATCCGATAGCGTAAATAGCTTTGTTACTCACTGTGTTAAGGGCTTAGAACCTAATATAGCACGCATTAATGAT
TTACGTGATAAATCGCTAATGCTTGTTACGGCTCTTAATCCGCATATCGGCTATGATAACGCCGCAAAAATTGCTAAAGA
AGCTCATAAGCATGGTATTACTCTAAAAGAAGCAGCTAAAAAACTCAATCTTTTATCGGAAGAAGATTTCGATAAAATAG
TAGTGCCTGTAAAAATGGTTGGACAACCTTAG

Upstream 100 bases:

>100_bases
AATTATATTATAGCTTTGCTAAATTAGCCCAGCAATTAGACTTGAATGTAGCAAGTAATCATTTTATGAAAAAAGATAAT
TATATAACATTTAACAATTT

Downstream 100 bases:

>100_bases
GTTTGGTGCTAAAATATAAATTTTGACTATTAATATTACTGCACAAAATCTTATAAATATGCTAGTATTAAATTAGTTTA
TTTATTGTATTGCCTGTGTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNYEFGDLEAKIATSIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTSKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNLLTALQDKSKDWGKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIGDALKKVYLLAQGGTAVGTGINSKI
GFDIRFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIAHDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEEDFDKIVVPVKMVGQP

Sequences:

>Translated_463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNYEFGDLEAKIATSIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTSKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNLLTALQDKSKDWGKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIGDALKKVYLLAQGGTAVGTGINSKI
GFDIRFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIAHDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEEDFDKIVVPVKMVGQP
>Mature_463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNYEFGDLEAKIATSIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTSKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNLLTALQDKSKDWGKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIGDALKKVYLLAQGGTAVGTGINSKI
GFDIRFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIAHDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEEDFDKIVVPVKMVGQP

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.9067245119306, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=57.1428571428571, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.9175704989154, Blast_Score=536, Evalue=1e-154,
Organism=Escherichia coli, GI87082375, Length=454, Percent_Identity=37.4449339207048, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=60.475161987041, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=63.5802469135803, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=61.1713665943601, Blast_Score=578, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=61.1231101511879, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=61.1231101511879, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=58.4415584415584, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=58.008658008658, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.0518358531317, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50785; Mature: 50785

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNY
CCCCCCCCCCCCEEEEECEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
EFGDLEAKIATSIDKATDRILEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTS
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQLIPALNNLLTALQDKSKDWGK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIGDALKKVYLLAQGGTAVGTGINSKI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCCCCC
GFDIRFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIAHDIRLLGS
CCEEHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GPRCGLGELHLPENEPGSSIMPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEE
FKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARINDLRDKSLMLVTALNPHIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCH
AAKIAKEAHKHGITLKEAAKKLNLLSEEDFDKIVVPVKMVGQP
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEHEECCCC
>Mature Secondary Structure
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNY
CCCCCCCCCCCCEEEEECEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
EFGDLEAKIATSIDKATDRILEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTS
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQLIPALNNLLTALQDKSKDWGK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIGDALKKVYLLAQGGTAVGTGINSKI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCCCCC
GFDIRFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIAHDIRLLGS
CCEEHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GPRCGLGELHLPENEPGSSIMPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEE
FKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARINDLRDKSLMLVTALNPHIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCH
AAKIAKEAHKHGITLKEAAKKLNLLSEEDFDKIVVPVKMVGQP
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA