Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 157826029

GI number: 157826029

Start: 890315

End: 891961

Strand: Reverse

Name: groEL [H]

Synonym: A1C_04925

Alternate gene names: 157826029

Gene position: 891961-890315 (Counterclockwise)

Preceding gene: 157826030

Following gene: 157826028

Centisome position: 72.45

GC content: 38.8

Gene sequence:

>1647_bases
ATGGCAACAAAACTTATTAAACACGGTTCAAAAGCTCGTGAGCAAATGCTAGAAGGCATTGACGTACTTGCAGATGCAGT
AAAAGTTACTTTAGGTCCAAAAGGCAGAAATGTACTTATTGAGCAATCATTCGGTTCACCGAAAATTACCAAAGACGGTG
TGACGGTTGCAAAATCGATCGAGTTAAAAGATAAAATTAGAAATGCTGGAGCTCAGCTATTAAAATCAGCTGCTACAAAA
GCTGCAGAAGTAGCCGGTGACGGTACTACTACAGCTACGGTACTTGCTAGAGCATTAGCTCGTGAGGGTAATAAGTTAGT
CGCAGCGGGCTATAATCCTATGGATTTAAAGCGTGGTATGGATTTAGCGGTAAACGCAGTAGTAGAAGAAATTAAAAAAT
CAAGTAAAAAAATCAATAGCCAAGAGGAAATTGCACAGGTTGGTACTATATCTTCAAACGGTGATAAGGAAATCGGTGAG
AAAATTGCTAAGGCAATGGAGGAAGTCGGTAAAGAAGGCGTGATAACTGTTGAAGAAGCAAAGAATTTTAGCTTCGATGT
TGAAGTAGTTAAAGGTATGATGTTTGATAGGGGTTATCTATCACCGTATTTTGTAACGAATTCCGAGAAAATGGTTGCTG
AACTTGAAAATCCTTTCATATTGCTATTTGAAAAAAAATTATCAAATTTACAACCGATGTTACCTATACTTGAGGCTGTA
GTACAATCACAACGCCCGTTGTTAATTATTGCTGAGGATGTTGAGGGCGAAGCTCTTGCAACGCTCGTGGTCAATAGATT
ACGTGGTGGTTTAAAAGTTGCGGCAGTAAAAGCGCCAGGTTTTGGTGATAGAAGAAAAGCAATGATGGAAGATATTGCTA
TCCTAACTAAAGGTGAGCTTATTACTGAAGATTTAGGTATGAAGCTTGAAAATGTGAGTATTAAAAGTCTAGGGACGGCA
AAGAGAGTAACAGTTTCTAAAGAAAATACCGTAATTGTTGATGGTAGCGGTGATAAGAAAAATATTGAAGATAGGGTATT
GCAAATTAAATCTCAAATAGCTGAAACTACTTCTGATTATGATAAAGAAAAACTACAAGAGCGTTTAGCTAAACTTTCCG
GTGGTGTTGCCGTATTAAAGGTTGGTGGTGCTACGGAAGTTGAAGTGAAAGAGCGTAAAGATCGTGTTGAAGATGCGCTT
GCTGCAACACGTGCTGCAGTTGAGGAAGGTGTTGTTGCCGGTGGCGGTGTAACATTACTTCATGCATCACAAACTTTAAC
AAAGCTTAAAGTCGAGAATAAGGATCAACAAGCAGGTATTGAGATAGTAATAGAAGCTTTAAAGGATCCGCTAAAACAGA
TTATTGAAAATGCCGGTGAAAACGGTGGCGTAGTAGTTGGTAAATTATTAGAACATAATGATAAAAATTATGGCTTTAAT
GCTCAAGATATGCAATATGTCGATATGATTAAAGCAGGAATTATTGATCCGGCTAAAGTAGTGCGTACTGCGCTTCAAGA
TGCTGCTTCCGTTGCTTCGTTAATTATTACCACGGAAACTTTAATTGTTGACGAACCTTCTGATAAAGAAGATGCAATGC
CGCCAATGCGTGGTGGTATGGGCGGTATGGGCGGTATGGATTTCTAA

Upstream 100 bases:

>100_bases
GTACCGAAATTGAAATTAAAGGCGAAAAACTGATCGTTATGAAAGAAAGCGATGTATTTGGTATTATTAATTAATTATTT
GTTTTAAGGAGAAATTAAAT

Downstream 100 bases:

>100_bases
GTCTATATCTACATAAGATAGGTGATGCAGTAGGTCTAATAAACTCGTCTTATTGCATTGCCTATTTCCATCATTTTGAG
GAGACATTGCGGCATGGATC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MATKLIKHGSKAREQMLEGIDVLADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATK
AAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGE
KIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTA
KRVTVSKENTVIVDGSGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDAL
AATRAAVEEGVVAGGGVTLLHASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIIENAGENGGVVVGKLLEHNDKNYGFN
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEDAMPPMRGGMGGMGGMDF

Sequences:

>Translated_548_residues
MATKLIKHGSKAREQMLEGIDVLADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATK
AAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGE
KIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTA
KRVTVSKENTVIVDGSGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDAL
AATRAAVEEGVVAGGGVTLLHASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIIENAGENGGVVVGKLLEHNDKNYGFN
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEDAMPPMRGGMGGMGGMDF
>Mature_547_residues
ATKLIKHGSKAREQMLEGIDVLADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATKA
AEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEK
IAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAVV
QSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTAK
RVTVSKENTVIVDGSGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALA
ATRAAVEEGVVAGGGVTLLHASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIIENAGENGGVVVGKLLEHNDKNYGFNA
QDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEDAMPPMRGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=53.875236294896, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=53.875236294896, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI5453607, Length=563, Percent_Identity=24.5115452930728, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=60.7142857142857, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=53.4839924670433, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=214, Percent_Identity=52.803738317757, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17564182, Length=574, Percent_Identity=22.8222996515679, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=483, Percent_Identity=23.3954451345756, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147750, Length=133, Percent_Identity=37.593984962406, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=57.2519083969466, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6322524, Length=564, Percent_Identity=22.3404255319149, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=53.4971644612476, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=53.4971644612476, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=52.0992366412214, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=52.0992366412214, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=52.0992366412214, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=45.0090744101633, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=37.9047619047619, Blast_Score=323, Evalue=3e-88,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=37.9047619047619, Blast_Score=323, Evalue=3e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58692; Mature: 58560

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKLIKHGSKAREQMLEGIDVLADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSI
CCCHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELKDKIRNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCC
DLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECC
KNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
CCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGEL
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ITEDLGMKLENVSIKSLGTAKRVTVSKENTVIVDGSGDKKNIEDRVLQIKSQIAETTSDY
HHHHHCCEEECCCHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
HASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIIENAGENGGVVVGKLLEHNDKNYGFN
ECHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCC
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEDAMPPMRGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC
>Mature Secondary Structure 
ATKLIKHGSKAREQMLEGIDVLADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSI
CCHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELKDKIRNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCC
DLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECC
KNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
CCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGEL
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ITEDLGMKLENVSIKSLGTAKRVTVSKENTVIVDGSGDKKNIEDRVLQIKSQIAETTSDY
HHHHHCCEEECCCHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
HASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIIENAGENGGVVVGKLLEHNDKNYGFN
ECHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCC
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEDAMPPMRGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA