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The map label for this gene is pccB [H]

Identifier: 157826018

GI number: 157826018

Start: 877333

End: 878877

Strand: Reverse

Name: pccB [H]

Synonym: A1C_04860

Alternate gene names: 157826018

Gene position: 878877-877333 (Counterclockwise)

Preceding gene: 157826022

Following gene: 157826017

Centisome position: 71.39

GC content: 39.81

Gene sequence:

>1545_bases
ATGACTCAAAGTAATATAATCTCCCTTGAGTTATTGGATGAGAGAAAAAATATTGCAAGGCAAGGGGGCGGTGAAGCTAG
GATCAACGCACAACATCAAAAAGGTAAGTTAACTGCACGAGAACGCATAGAAGTATTATTAGATCCGAATAGTTTTACCG
AAACTGGGATGTTTGTAGCACATAGATGCGATAATTTTGGGATGCAGGATAAAAAGTTTTTAGGTGACGGTGTTGTAACT
GGGCATGGTACGATAAACGGTAGATTGGTATTTATTTACAGCCAAGATTTTACCGTACTAGGCGGTTCTCTCGGCGAATA
TCATGCTAAGAAAATCTGCGATATTATCGATCAAGCTATAGCAACCGGTGCTCCAGTAATAGGTATTAACGACTCAGGGG
GAGCAAGAATTCAAGAAGGGGTTGATGCTCTTGCCGGATACGGTGAATTATTTCAGCGTAATGTGTTAGCGTCAGGTGTT
ATCCCTCAAATTACCTTAATTATGGGACCTTGTGCCGGTGGTGCGGTATATTCCCCTGCCTTAACTGATTTTATATTTAT
GGTTAAGAATAGTTCTTATATGTTCGTAACCGGTCCCGATGTAGTAAAAACTGTTACGGGTGAAGCAGTAAGCCAAGAAA
AGCTCGGCGGTGCTAGAATGCATACCACTAAAAGCGGTGTTGCCGATCTTGCATTCAATAATGATATAGAAGCATTGCTC
GAAATCCGTAAGTTCTTTAATTTCCTTCCATCATCCAATCGTAGTCCTCTTCCTGTTCGTTCGACTATTGATCCTGCCGA
TAGAGTCGATATGTCTCTTAGCACGTTAATACCTAACACTCCTAATAAGCCTTATGATATGAAAGAGCTTGTTGAGCGTA
TCGTTGATGAGGGAGAATTTTTTGAACTACAATCTGATTTTGCCAAGAATATCATTATCGGATTTGGTTATATGGAAGGT
TATACGGTAGGATTTGTGGCTAATCAGCCTTTGCATTTAGCAGGATGTTTAGATATAAACGCCTCAAGAAAAGCAGCAAG
ATTTATTAGATTCTGTGATGCTTTCAATATTCCTATAGTAAGTCTTGTGGATGTACCTGGATTTCTGCCTGGTACATCCC
AAGAGCATGACGGTATTATTAAACACGGTGCTAAGCTGTTATACGCGTATGCAGAAGCTACAGTGCCGAAGATTACCGTA
ATTACCCGTAAGGCTTACGGTGGTGCTTATATAGTTATGAACTCCAAGCATCTTAGAGGCGATATAAACTATGCTTGGTT
TAATTCAGAAATCGCTGTTATGGGGGCAGAGGGAGCAGCCGAGATAATATTTAAGGAAGAATGTAAAGACCCTGAAGCTA
AAAAACAAAAAATCGATGAATATAGAAAGGTAGTAACTTCGCCTTTTGTTGCGGCATCTAGGGGATATTTGGATGATATT
ATAAGACCGCAAAATACTAGATGGCGAATATGTAAGGCGTTAAATTTCCTGCGTACTAAAAAAGTAGAATTGCCTTGGAA
AAAGCATGATAATTTGCCGTTGTAA

Upstream 100 bases:

>100_bases
TTCTTTAGTATCTTCGGTAGATGACATAAATAATTATCTTTTCACGTTAGCATTATTATATTATATTATGGATATTTTGG
AAATAAAACTATAAATATTT

Downstream 100 bases:

>100_bases
TGTTTAATTGTCATTCCAGCGAAAGTGGAATCCAGAAAAACATATATACAGCAAATTTTTGCAATTAAAAGCTCGATTTA
TCTCGCTTTATGCTGAATTC

Product: propionyl-CoA carboxylase beta chain precursor

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTQSNIISLELLDERKNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVAHRCDNFGMQDKKFLGDGVVT
GHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIATGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGV
IPQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEAVSQEKLGGARMHTTKSGVADLAFNNDIEALL
EIRKFFNFLPSSNRSPLPVRSTIDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQSDFAKNIIIGFGYMEG
YTVGFVANQPLHLAGCLDINASRKAARFIRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITV
ITRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKDPEAKKQKIDEYRKVVTSPFVAASRGYLDDI
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL

Sequences:

>Translated_514_residues
MTQSNIISLELLDERKNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVAHRCDNFGMQDKKFLGDGVVT
GHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIATGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGV
IPQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEAVSQEKLGGARMHTTKSGVADLAFNNDIEALL
EIRKFFNFLPSSNRSPLPVRSTIDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQSDFAKNIIIGFGYMEG
YTVGFVANQPLHLAGCLDINASRKAARFIRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITV
ITRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKDPEAKKQKIDEYRKVVTSPFVAASRGYLDDI
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
>Mature_513_residues
TQSNIISLELLDERKNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVAHRCDNFGMQDKKFLGDGVVTG
HGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIATGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGVI
PQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEAVSQEKLGGARMHTTKSGVADLAFNNDIEALLE
IRKFFNFLPSSNRSPLPVRSTIDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQSDFAKNIIIGFGYMEGY
TVGFVANQPLHLAGCLDINASRKAARFIRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITVI
TRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKDPEAKKQKIDEYRKVVTSPFVAASRGYLDDII
RPQNTRWRICKALNFLRTKKVELPWKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=63.905325443787, Blast_Score=677, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=61.4800759013283, Blast_Score=664, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=496, Percent_Identity=32.6612903225806, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI134142062, Length=418, Percent_Identity=24.6411483253589, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679960, Length=409, Percent_Identity=24.4498777506112, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679977, Length=409, Percent_Identity=24.4498777506112, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679967, Length=409, Percent_Identity=24.4498777506112, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679974, Length=409, Percent_Identity=24.4498777506112, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679971, Length=409, Percent_Identity=24.4498777506112, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=62.2266401590457, Blast_Score=673, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=62.2266401590457, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=523, Percent_Identity=32.5047801147228, Blast_Score=237, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=362, Percent_Identity=22.6519337016575, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586065, Length=514, Percent_Identity=33.6575875486381, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56556; Mature: 56424

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSNIISLELLDERKNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVA
CCCCCEEEEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCEEE
HRCDNFGMQDKKFLGDGVVTGHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAI
ECCCCCCCCCHHHCCCCEEECCCEECCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
ATGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGVIPQITLIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LTDFIFMVKNSSYMFVTGPDVVKTVTGEAVSQEKLGGARMHTTKSGVADLAFNNDIEALL
HHHEEEEEECCCEEEEECCHHHHHHCCCHHHHHHCCCCEEEECCCCCEEEEECCCHHHHH
EIRKFFNFLPSSNRSPLPVRSTIDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEF
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCE
FELQSDFAKNIIIGFGYMEGYTVGFVANQPLHLAGCLDINASRKAARFIRFCDAFNIPIV
EEHHHHHHCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEE
SLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYIVMNSKHLRG
EEECCCCCCCCCCCCCCCHHHHHHHHEEHHHHCCCCEEEEEEEECCCCEEEEECCCCCCC
DINYAWFNSEIAVMGAEGAAEIIFKEECKDPEAKKQKIDEYRKVVTSPFVAASRGYLDDI
CCEEEEECCEEEEEECCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHH
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQSNIISLELLDERKNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVA
CCCCEEEEEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCEEE
HRCDNFGMQDKKFLGDGVVTGHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAI
ECCCCCCCCCHHHCCCCEEECCCEECCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
ATGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGVIPQITLIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LTDFIFMVKNSSYMFVTGPDVVKTVTGEAVSQEKLGGARMHTTKSGVADLAFNNDIEALL
HHHEEEEEECCCEEEEECCHHHHHHCCCHHHHHHCCCCEEEECCCCCEEEEECCCHHHHH
EIRKFFNFLPSSNRSPLPVRSTIDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEF
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCE
FELQSDFAKNIIIGFGYMEGYTVGFVANQPLHLAGCLDINASRKAARFIRFCDAFNIPIV
EEHHHHHHCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEE
SLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYIVMNSKHLRG
EEECCCCCCCCCCCCCCCHHHHHHHHEEHHHHCCCCEEEEEEEECCCCEEEEECCCCCCC
DINYAWFNSEIAVMGAEGAAEIIFKEECKDPEAKKQKIDEYRKVVTSPFVAASRGYLDDI
CCEEEEECCEEEEEECCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHH
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]