Click here to switch to the map view.

The map label for this gene is pth

Identifier: 157825997

GI number: 157825997

Start: 855694

End: 856251

Strand: Reverse

Name: pth

Synonym: A1C_04745

Alternate gene names: 157825997

Gene position: 856251-855694 (Counterclockwise)

Preceding gene: 157825998

Following gene: 157825996

Centisome position: 69.55

GC content: 30.47

Gene sequence:

>558_bases
ATGATTCTTGTTATTGGTCTTGGTAATCCAGGAAAAGAGTATCAATATACGAGGCATAATATCGGCTTTATTGCTATAGA
GAAAATAGCAAACCAATATAATTCATCATTTAGTACAAAGAAACAATTCAATTGCGAGATTGCTGAAACTATTAGTGATG
GACAAAAGATTATTTTTATAAAGCCCACTACCTATATGAACTTGTCCGGTAAGTCAGTGATATCAGTGAAAACATATTAT
AATATCAACCCCGCAAAAATCTTTGTTATTCATGATGATATTGATTTAGAAACATGTAGAATAAAATTTAAAACCGGTGG
CGGTAACGGCGGGCATAACGGTTTAAAATCAATTGACGGTGTTATAGGCAATAATTATAATCGCATTAGGGTTGGGGTAG
GTAGACCAAAAAATAATCAGGATGTAGCAGATTACTTACTTAATAATTTCTTGCAATCCGAGTATGAAATAGCAATGCAA
GCTATAGATAGAATAGTTAATAATTTTGATTTAATATTAGAGAATAAGTTAGAAAAATTTAAGAATAAGATAGTATAA

Upstream 100 bases:

>100_bases
CGCTAGAAACGAGAATGACATTCTGAATACTCACGTACTTCTTCCAGATTAATATTTCTTCAAAAATTTTCCATTACTAT
TATTTATTAGGTAAATTATT

Downstream 100 bases:

>100_bases
AAATTGTCATTGTGAGGAGCGACACAACGCGGCAATCTCGTCAAATATCCTGAGATTGTCGCTCCTCGCAATGACTGTGT
GGTATCCACGCAACAATGCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSTKKQFNCEIAETISDGQKIIFIKPTTYMNLSGKSVISVKTYY
NINPAKIFVIHDDIDLETCRIKFKTGGGNGGHNGLKSIDGVIGNNYNRIRVGVGRPKNNQDVADYLLNNFLQSEYEIAMQ
AIDRIVNNFDLILENKLEKFKNKIV

Sequences:

>Translated_185_residues
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSTKKQFNCEIAETISDGQKIIFIKPTTYMNLSGKSVISVKTYY
NINPAKIFVIHDDIDLETCRIKFKTGGGNGGHNGLKSIDGVIGNNYNRIRVGVGRPKNNQDVADYLLNNFLQSEYEIAMQ
AIDRIVNNFDLILENKLEKFKNKIV
>Mature_185_residues
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSTKKQFNCEIAETISDGQKIIFIKPTTYMNLSGKSVISVKTYY
NINPAKIFVIHDDIDLETCRIKFKTGGGNGGHNGLKSIDGVIGNNYNRIRVGVGRPKNNQDVADYLLNNFLQSEYEIAMQ
AIDRIVNNFDLILENKLEKFKNKIV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=184, Percent_Identity=29.3478260869565, Blast_Score=103, Evalue=8e-23,
Organism=Escherichia coli, GI1787455, Length=184, Percent_Identity=36.4130434782609, Blast_Score=116, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_RICAH (A8GP84)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493717.1
- ProteinModelPortal:   A8GP84
- SMR:   A8GP84
- STRING:   A8GP84
- GeneID:   5645483
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_04745
- NMPDR:   fig|293614.3.peg.887
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   RAKA293614:A1C_04745-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20886; Mature: 20886

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSTKKQFNCEIAETISDGQKIIFI
CEEEEECCCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCHHCCCCHHHHHCCCCEEEEE
KPTTYMNLSGKSVISVKTYYNINPAKIFVIHDDIDLETCRIKFKTGGGNGGHNGLKSIDG
CCCEEEECCCCEEEEEEEEEECCCEEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHH
VIGNNYNRIRVGVGRPKNNQDVADYLLNNFLQSEYEIAMQAIDRIVNNFDLILENKLEKF
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNKIV
HHCCC
>Mature Secondary Structure
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSTKKQFNCEIAETISDGQKIIFI
CEEEEECCCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCHHCCCCHHHHHCCCCEEEEE
KPTTYMNLSGKSVISVKTYYNINPAKIFVIHDDIDLETCRIKFKTGGGNGGHNGLKSIDG
CCCEEEECCCCEEEEEEEEEECCCEEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHH
VIGNNYNRIRVGVGRPKNNQDVADYLLNNFLQSEYEIAMQAIDRIVNNFDLILENKLEKF
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNKIV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA