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The map label for this gene is mrdA [H]

Identifier: 157825937

GI number: 157825937

Start: 789117

End: 790901

Strand: Reverse

Name: mrdA [H]

Synonym: A1C_04385

Alternate gene names: 157825937

Gene position: 790901-789117 (Counterclockwise)

Preceding gene: 157825938

Following gene: 157825936

Centisome position: 64.25

GC content: 34.62

Gene sequence:

>1785_bases
ATGCTAAATAAAAAAATACTACATGGTGAGTTAATTTCACGAAGGGCCTTTATAATCGGGTTAGGTAAACTCGGATTTTT
ATCACTGCTTGGAATAAGAATGTTTTATTTGCAGCTTATTAAAAGTGAAGAATATAAGACTTTATCAGATAAGAATCGTA
TTAATTTTGTTGTACTTCCGCCGACCAGAGGAAGAATTTATGATGTAGACGGCAGTATCTTAGCTACTAATAAACCATGT
TATCAGTTAGTAATAGATAGGAGCATTAATAATAATTATCTGGATGAATTAGCAATAGTTAGTAATATTCTAAATTTATC
TCCGGAAAAATATAATTATATTAAGCAAAAAATTAAAAAATCTAGTCGCCACACTCCTGTAATAATACTTGATCAGCTCG
ATTGGCAGCAAGTATCAATGGTTGAAGAACAAAAGCATAAACTAGCTTCAATATTCATTGATATAGGATATTTAAGATTT
TATCCTTTTTCAAGCACTACTTCTCATTTAATCGGTTATCTAGGTCAAATAAATGAACAAGAGAAGCAAGAGTTAAATAT
ACATAGCTTAAGCGATTTTAATATTGGTAAATACGGTATCGAAAAATATTACGATAGTAAATTACGAGGAGAATTCGGTT
ATAAAAAAGTTGAAGTAAACGCTTACGGTAAGCAGGTAAGAGAAATAGCAGGAACCCCTACTAAAGCTGGTAAAGATATG
TATTTAAATATCGATGCTTCTCTTCAGCAAAATATCCAGCAATATTTAAATCCTAAAGGCTCTTCGGCAATAGTTATGGA
TACTAGAAGCGGAAACATACTAATTTGTGCTTCCACACCGGGTTTTGAATCAAATAATTTCAATAAATTATCGGAAAATT
ATTGGCAAAGTTTAATTAGCAATCCTTATAAGCCTTTAATTAATAAGGTAATACAAAGCTCGTATCCCCCAGGTTCGGTT
TTTAAAATAATTACCGTACTTGCAGCCCTTGAAGTAGGCATTAATCCTAATAAAACCGTTTTTTGCGACGGTAGCTCTGC
TCTTGGTACTAATAGCTTTAGATGTTGGAATCATAGCGGGCATGGGACGGTAGATATGATGTCTGCTTTAAAGCATTCTT
GTAATATTTATATGTATGCACTCGCAAGAATAGTAGGTCCGGATAAAATTCTTGAAGTTGCAAGAGAATTTGGCCTCGGC
TCAAAGACCGGTATTGATTTAGCTCCTGAAAGTAGTGGATTTGTACCGTCAAAAGAATGGAAAAAGAAAAAATTACAGAT
TCCTTGGTCAATAGGTGATAGCTTTAATTTGGCAATCGGGCAAGGATTTTTAGGAGTAACGCCGATTCAGCTTGCAAGAT
TTATTACGGCTATTGCAAGTAACGGTAAACTATATACGCCTAGAATATTAAAAAATGATTCGGAATTTTATAATGTTAAT
ATTAAGCCTGAAAATATCAAAATAATACAAGAAAGTTTATATAATACTGTGAATGTTGCGGGAGGTACGGCGTATTATAA
TAGAATTTTAGGTAAAAATAGGCAGCTTGCTGGTAAAACCGGTACTTCCCAAGTACAAGGCAAACTAAATGCTAAAGACG
ATTTAAGCCGTGACTCTATTGCCTGGGAGAGGCGTAATCATGCTTTGTTCTTGGGCTTCGCTCCTTATCACGATCCTCTT
TATTCCGTTACTGTTTTTGTTGACCATGGAGGAGGCGGTAGTAAAGCCGCCGCCCCAATAGCTCGTAAAATCATGTCTGA
CGTGCTGGATAAGTATACTCGTTGA

Upstream 100 bases:

>100_bases
GACGGATATTTAATAATTTGCTTTCAATTTTTAACAACTATATTTTCTTACAATATAATGCGTCTTATACTTGATTCTCC
TATGAATTACTTTAAAAAGT

Downstream 100 bases:

>100_bases
ATTTGAAAAATTGGCTTAGTTGTACTTGACTATAGTATGTACGCTGCGGTTAAAAGATTCAAAACAGATTCCTCTTTTCC
AAATTGAGCTTCATATACCT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MLNKKILHGELISRRAFIIGLGKLGFLSLLGIRMFYLQLIKSEEYKTLSDKNRINFVVLPPTRGRIYDVDGSILATNKPC
YQLVIDRSINNNYLDELAIVSNILNLSPEKYNYIKQKIKKSSRHTPVIILDQLDWQQVSMVEEQKHKLASIFIDIGYLRF
YPFSSTTSHLIGYLGQINEQEKQELNIHSLSDFNIGKYGIEKYYDSKLRGEFGYKKVEVNAYGKQVREIAGTPTKAGKDM
YLNIDASLQQNIQQYLNPKGSSAIVMDTRSGNILICASTPGFESNNFNKLSENYWQSLISNPYKPLINKVIQSSYPPGSV
FKIITVLAALEVGINPNKTVFCDGSSALGTNSFRCWNHSGHGTVDMMSALKHSCNIYMYALARIVGPDKILEVAREFGLG
SKTGIDLAPESSGFVPSKEWKKKKLQIPWSIGDSFNLAIGQGFLGVTPIQLARFITAIASNGKLYTPRILKNDSEFYNVN
IKPENIKIIQESLYNTVNVAGGTAYYNRILGKNRQLAGKTGTSQVQGKLNAKDDLSRDSIAWERRNHALFLGFAPYHDPL
YSVTVFVDHGGGGSKAAAPIARKIMSDVLDKYTR

Sequences:

>Translated_594_residues
MLNKKILHGELISRRAFIIGLGKLGFLSLLGIRMFYLQLIKSEEYKTLSDKNRINFVVLPPTRGRIYDVDGSILATNKPC
YQLVIDRSINNNYLDELAIVSNILNLSPEKYNYIKQKIKKSSRHTPVIILDQLDWQQVSMVEEQKHKLASIFIDIGYLRF
YPFSSTTSHLIGYLGQINEQEKQELNIHSLSDFNIGKYGIEKYYDSKLRGEFGYKKVEVNAYGKQVREIAGTPTKAGKDM
YLNIDASLQQNIQQYLNPKGSSAIVMDTRSGNILICASTPGFESNNFNKLSENYWQSLISNPYKPLINKVIQSSYPPGSV
FKIITVLAALEVGINPNKTVFCDGSSALGTNSFRCWNHSGHGTVDMMSALKHSCNIYMYALARIVGPDKILEVAREFGLG
SKTGIDLAPESSGFVPSKEWKKKKLQIPWSIGDSFNLAIGQGFLGVTPIQLARFITAIASNGKLYTPRILKNDSEFYNVN
IKPENIKIIQESLYNTVNVAGGTAYYNRILGKNRQLAGKTGTSQVQGKLNAKDDLSRDSIAWERRNHALFLGFAPYHDPL
YSVTVFVDHGGGGSKAAAPIARKIMSDVLDKYTR
>Mature_594_residues
MLNKKILHGELISRRAFIIGLGKLGFLSLLGIRMFYLQLIKSEEYKTLSDKNRINFVVLPPTRGRIYDVDGSILATNKPC
YQLVIDRSINNNYLDELAIVSNILNLSPEKYNYIKQKIKKSSRHTPVIILDQLDWQQVSMVEEQKHKLASIFIDIGYLRF
YPFSSTTSHLIGYLGQINEQEKQELNIHSLSDFNIGKYGIEKYYDSKLRGEFGYKKVEVNAYGKQVREIAGTPTKAGKDM
YLNIDASLQQNIQQYLNPKGSSAIVMDTRSGNILICASTPGFESNNFNKLSENYWQSLISNPYKPLINKVIQSSYPPGSV
FKIITVLAALEVGINPNKTVFCDGSSALGTNSFRCWNHSGHGTVDMMSALKHSCNIYMYALARIVGPDKILEVAREFGLG
SKTGIDLAPESSGFVPSKEWKKKKLQIPWSIGDSFNLAIGQGFLGVTPIQLARFITAIASNGKLYTPRILKNDSEFYNVN
IKPENIKIIQESLYNTVNVAGGTAYYNRILGKNRQLAGKTGTSQVQGKLNAKDDLSRDSIAWERRNHALFLGFAPYHDPL
YSVTVFVDHGGGGSKAAAPIARKIMSDVLDKYTR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=600, Percent_Identity=31.3333333333333, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1786272, Length=605, Percent_Identity=25.7851239669421, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66482; Mature: 66482

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKKILHGELISRRAFIIGLGKLGFLSLLGIRMFYLQLIKSEEYKTLSDKNRINFVVLP
CCCCCCHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
PTRGRIYDVDGSILATNKPCYQLVIDRSINNNYLDELAIVSNILNLSPEKYNYIKQKIKK
CCCCEEEECCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SSRHTPVIILDQLDWQQVSMVEEQKHKLASIFIDIGYLRFYPFSSTTSHLIGYLGQINEQ
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHCCCCH
EKQELNIHSLSDFNIGKYGIEKYYDSKLRGEFGYKKVEVNAYGKQVREIAGTPTKAGKDM
HHHHCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEE
YLNIDASLQQNIQQYLNPKGSSAIVMDTRSGNILICASTPGFESNNFNKLSENYWQSLIS
EEEECHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
NPYKPLINKVIQSSYPPGSVFKIITVLAALEVGINPNKTVFCDGSSALGTNSFRCWNHSG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCC
HGTVDMMSALKHSCNIYMYALARIVGPDKILEVAREFGLGSKTGIDLAPESSGFVPSKEW
CCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHH
KKKKLQIPWSIGDSFNLAIGQGFLGVTPIQLARFITAIASNGKLYTPRILKNDSEFYNVN
HHCEEECCEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCHHCCCCCCEEEEE
IKPENIKIIQESLYNTVNVAGGTAYYNRILGKNRQLAGKTGTSQVQGKLNAKDDLSRDSI
ECCCHHHHHHHHHHCEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCH
AWERRNHALFLGFAPYHDPLYSVTVFVDHGGGGSKAAAPIARKIMSDVLDKYTR
HHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNKKILHGELISRRAFIIGLGKLGFLSLLGIRMFYLQLIKSEEYKTLSDKNRINFVVLP
CCCCCCHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
PTRGRIYDVDGSILATNKPCYQLVIDRSINNNYLDELAIVSNILNLSPEKYNYIKQKIKK
CCCCEEEECCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SSRHTPVIILDQLDWQQVSMVEEQKHKLASIFIDIGYLRFYPFSSTTSHLIGYLGQINEQ
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHCCCCH
EKQELNIHSLSDFNIGKYGIEKYYDSKLRGEFGYKKVEVNAYGKQVREIAGTPTKAGKDM
HHHHCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEE
YLNIDASLQQNIQQYLNPKGSSAIVMDTRSGNILICASTPGFESNNFNKLSENYWQSLIS
EEEECHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
NPYKPLINKVIQSSYPPGSVFKIITVLAALEVGINPNKTVFCDGSSALGTNSFRCWNHSG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCC
HGTVDMMSALKHSCNIYMYALARIVGPDKILEVAREFGLGSKTGIDLAPESSGFVPSKEW
CCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHH
KKKKLQIPWSIGDSFNLAIGQGFLGVTPIQLARFITAIASNGKLYTPRILKNDSEFYNVN
HHCEEECCEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCHHCCCCCCEEEEE
IKPENIKIIQESLYNTVNVAGGTAYYNRILGKNRQLAGKTGTSQVQGKLNAKDDLSRDSI
ECCCHHHHHHHHHHCEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCH
AWERRNHALFLGFAPYHDPLYSVTVFVDHGGGGSKAAAPIARKIMSDVLDKYTR
HHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]