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The map label for this gene is paaH [C]

Identifier: 157825925

GI number: 157825925

Start: 776810

End: 778975

Strand: Reverse

Name: paaH [C]

Synonym: A1C_04325

Alternate gene names: 157825925

Gene position: 778975-776810 (Counterclockwise)

Preceding gene: 157825926

Following gene: 157825923

Centisome position: 63.28

GC content: 33.29

Gene sequence:

>2166_bases
ATGCAAAATGAAATAAAAAAAATTTGTGTTATCGGTTCAGGGGTAATGGGTTCAGGGATTGCAGCGTTAATTGCTAATTC
CTCTCATAAAGTCGTATTACTGGATATTATCGCTAAAGATTCTGATGATCCTAATAAAATAGTAAAAAATGCTATAGAGA
ATTTGCATAAACAAAAACCTCCCCCTTTATCTTGTCCCGATAAAGCAAATTTCATTACCATCGGTACTTTAGAACATGAT
TTAGATTTAATTACAGAATGTGATTTAATTATTGAAGTTATTGTTGAGAAGTTAGAAATCAAGCACCAATTATATAACAA
ACTTATTCCTTATCTTAAAGAAGAGGCAATTATTGCTTCTAATACTTCTACATTACCTCTTAAAAGACTAAAAGAGAATT
TACCGGATAATATCAAATCGAGATTTGTTATTACGCATTTCTTCAACCCGCCAAGATATATGGAACTGCTTGAGTTAATT
ATAGACCATATGGTAAAGGTTGAAGCCATAGAAAGAGTATCAGAGTTCTTAACGAAAACGCTTGGTAAAACTATAGTCAG
ATGTAATGATACACCTGGTTTTATTGCTAATAGAGTAGGGTGTTTTTTACTGGAGTTAGTAGTCCGCAAAGCGATAAGTC
AAAAGCTTAATTTTGTAGCTTTGGATAAAATATTTACTACATGTTTGGGGCTGCCGAGTACCGGAATTTTTGGTTTATAT
GATCTAATAGGACATGACGTCATGAAGTTAATATCAAGCTCATTACTTGCTGCCCTTCCTGCAAAGGATGCTTATCATAA
AATATATGTCAATACTCCCGTTCTTGATAAGATGATTGGGAGGAAGTTAATTGGGCGTAAAGGCTGTGGTGGATTTTATC
GTTTATCGGTATCAAATGGCAAAAAGATTCAAGAAGTTATCAATATAAACGACTTATCATATAGTCCTGTTCAAAAAGTA
GATATTTCATTTAAGAATCTTGATGAGTTACTAGCTAGCGATTCAGTTTACGGTAAATTTTTTACTGAAATTATCACAGA
ATTTTATGTTTATTTAGCAAGCTTAGTACCATCTGTAACCGATAATATCTATGATATCGATGCTGCTATGAAGCTTGGTT
ACAGTTGGAAATACGGTCCATTTGAATTATTGACCATAGCAGCTAAAGACGGCTGGAATTCGATCATTAAAAATACCGAT
TTAATGCACATCCCACTTCCGCAATATTTAGGTAATAAAGAATATCAAAAAATCGATAAACAAAAATTTAATTCTCACAA
AGATATTTTAAAGGAAAGTCAGATAGTATTAGAAAACGATTCTGCAAAGCTAATAAATTATCGTGAGAATTTAGTGTTTG
TTATTACTACGAAAATGAATTGTTTAAATCATAATGTGTTTTATTTACTGCAAGAAGCAGCAAGTAAAGCTGAAAATGAC
GGCAAAAATCTTTATATCTATCCGCAAGGAAATCATTTTTCTGCTGGTGCGGATTTAAAGCTTCTTCTCTCCTATATTGA
GGATAAAAATTTTCATGATTTAGAGAATTTACTAAAGCTGGGACAGCAAACCATGCTTCACTTAAAATATTCTGCAGCTC
ATATTGTTAGTTGTGCCAAAGGAGTAGCCCTTGGAGGCGGGTGTGAGCTGCTATTGTACTCAAGCTATATTGTCGCAAAT
AATGAACTGAGTGCTGGACTTGTAGAACTTGGAGTCGGTTTAATACCTGGGTGGGGCGGTGTTACCGTAATGTTTGCTCG
CGCTAGAGGAGATAAAACTAAACTAATTAGAAATGTTAGAAATATTATAGAGCAGAATAAAACAAGTTCAGCCGATTACG
TGAAAGCAGATTATGATGTAGAGAATATGCAAGTAAATATGAACAAGCATTACATTCTCGATGAAGCTTTAAAGCTGAAC
CTATCTAAAAAAATAGTACCGGCTACCCATAAAGTTACTTTGCCCAAAATCAATTTAGCAACTGAAATAGATATATCAAA
ATATAACGATCTACAAAATAAGGTACTTAGCAAGTTTCAAACCATTATAGATCAACATAATGAAACGAATGAAGAATCGC
TATTTGCCTATGAGCGTGACATATTTTTAGAACTTGCAAAAGATCCAAAAACTATAGAGAAGTTGAAAGTTGTGTTGGGG
CATTGA

Upstream 100 bases:

>100_bases
TAAAAACATGCTATGTATTGTTAACTGGATTGCTTCGTCAAAATTTTCAATTTTTCCTCGTAATGACGATTAAATAAAAC
CATCAAGAGTGAAGTAACTT

Downstream 100 bases:

>100_bases
TGTCACTTGCAATGACATAGAGAGCATTTACCGGTCCACGCAACAATGCTTCTCACTGGAATTACATAAAAGCCATGCTG
TGGTAACTGTGGTAACACTA

Product: 3-hydroxyacyl-CoA dehydrogenase FadB

Products: NA

Alternate protein names: 3-hydroxyacyl-CoA dehydrogenase; Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase [H]

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MQNEIKKICVIGSGVMGSGIAALIANSSHKVVLLDIIAKDSDDPNKIVKNAIENLHKQKPPPLSCPDKANFITIGTLEHD
LDLITECDLIIEVIVEKLEIKHQLYNKLIPYLKEEAIIASNTSTLPLKRLKENLPDNIKSRFVITHFFNPPRYMELLELI
IDHMVKVEAIERVSEFLTKTLGKTIVRCNDTPGFIANRVGCFLLELVVRKAISQKLNFVALDKIFTTCLGLPSTGIFGLY
DLIGHDVMKLISSSLLAALPAKDAYHKIYVNTPVLDKMIGRKLIGRKGCGGFYRLSVSNGKKIQEVININDLSYSPVQKV
DISFKNLDELLASDSVYGKFFTEIITEFYVYLASLVPSVTDNIYDIDAAMKLGYSWKYGPFELLTIAAKDGWNSIIKNTD
LMHIPLPQYLGNKEYQKIDKQKFNSHKDILKESQIVLENDSAKLINYRENLVFVITTKMNCLNHNVFYLLQEAASKAEND
GKNLYIYPQGNHFSAGADLKLLLSYIEDKNFHDLENLLKLGQQTMLHLKYSAAHIVSCAKGVALGGGCELLLYSSYIVAN
NELSAGLVELGVGLIPGWGGVTVMFARARGDKTKLIRNVRNIIEQNKTSSADYVKADYDVENMQVNMNKHYILDEALKLN
LSKKIVPATHKVTLPKINLATEIDISKYNDLQNKVLSKFQTIIDQHNETNEESLFAYERDIFLELAKDPKTIEKLKVVLG
H

Sequences:

>Translated_721_residues
MQNEIKKICVIGSGVMGSGIAALIANSSHKVVLLDIIAKDSDDPNKIVKNAIENLHKQKPPPLSCPDKANFITIGTLEHD
LDLITECDLIIEVIVEKLEIKHQLYNKLIPYLKEEAIIASNTSTLPLKRLKENLPDNIKSRFVITHFFNPPRYMELLELI
IDHMVKVEAIERVSEFLTKTLGKTIVRCNDTPGFIANRVGCFLLELVVRKAISQKLNFVALDKIFTTCLGLPSTGIFGLY
DLIGHDVMKLISSSLLAALPAKDAYHKIYVNTPVLDKMIGRKLIGRKGCGGFYRLSVSNGKKIQEVININDLSYSPVQKV
DISFKNLDELLASDSVYGKFFTEIITEFYVYLASLVPSVTDNIYDIDAAMKLGYSWKYGPFELLTIAAKDGWNSIIKNTD
LMHIPLPQYLGNKEYQKIDKQKFNSHKDILKESQIVLENDSAKLINYRENLVFVITTKMNCLNHNVFYLLQEAASKAEND
GKNLYIYPQGNHFSAGADLKLLLSYIEDKNFHDLENLLKLGQQTMLHLKYSAAHIVSCAKGVALGGGCELLLYSSYIVAN
NELSAGLVELGVGLIPGWGGVTVMFARARGDKTKLIRNVRNIIEQNKTSSADYVKADYDVENMQVNMNKHYILDEALKLN
LSKKIVPATHKVTLPKINLATEIDISKYNDLQNKVLSKFQTIIDQHNETNEESLFAYERDIFLELAKDPKTIEKLKVVLG
H
>Mature_721_residues
MQNEIKKICVIGSGVMGSGIAALIANSSHKVVLLDIIAKDSDDPNKIVKNAIENLHKQKPPPLSCPDKANFITIGTLEHD
LDLITECDLIIEVIVEKLEIKHQLYNKLIPYLKEEAIIASNTSTLPLKRLKENLPDNIKSRFVITHFFNPPRYMELLELI
IDHMVKVEAIERVSEFLTKTLGKTIVRCNDTPGFIANRVGCFLLELVVRKAISQKLNFVALDKIFTTCLGLPSTGIFGLY
DLIGHDVMKLISSSLLAALPAKDAYHKIYVNTPVLDKMIGRKLIGRKGCGGFYRLSVSNGKKIQEVININDLSYSPVQKV
DISFKNLDELLASDSVYGKFFTEIITEFYVYLASLVPSVTDNIYDIDAAMKLGYSWKYGPFELLTIAAKDGWNSIIKNTD
LMHIPLPQYLGNKEYQKIDKQKFNSHKDILKESQIVLENDSAKLINYRENLVFVITTKMNCLNHNVFYLLQEAASKAEND
GKNLYIYPQGNHFSAGADLKLLLSYIEDKNFHDLENLLKLGQQTMLHLKYSAAHIVSCAKGVALGGGCELLLYSSYIVAN
NELSAGLVELGVGLIPGWGGVTVMFARARGDKTKLIRNVRNIIEQNKTSSADYVKADYDVENMQVNMNKHYILDEALKLN
LSKKIVPATHKVTLPKINLATEIDISKYNDLQNKVLSKFQTIIDQHNETNEESLFAYERDIFLELAKDPKTIEKLKVVLG
H

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=294, Percent_Identity=31.2925170068027, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI296179427, Length=314, Percent_Identity=29.9363057324841, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI20127408, Length=389, Percent_Identity=25.4498714652956, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI261878539, Length=315, Percent_Identity=26.031746031746, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI68989263, Length=400, Percent_Identity=24.5, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1787661, Length=344, Percent_Identity=28.1976744186047, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790281, Length=245, Percent_Identity=29.3877551020408, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=31.5436241610738, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=298, Percent_Identity=30.8724832214765, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17558304, Length=290, Percent_Identity=28.6206896551724, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508953, Length=259, Percent_Identity=29.3436293436293, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25144276, Length=259, Percent_Identity=29.3436293436293, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=315, Percent_Identity=26.984126984127, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508951, Length=259, Percent_Identity=29.3436293436293, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=299, Percent_Identity=24.7491638795987, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985930, Length=386, Percent_Identity=24.0932642487047, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129993, Length=226, Percent_Identity=26.1061946902655, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45549573, Length=238, Percent_Identity=23.109243697479, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35; =4.2.1.17; =5.3.3.8 [H]

Molecular weight: Translated: 80986; Mature: 80986

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNEIKKICVIGSGVMGSGIAALIANSSHKVVLLDIIAKDSDDPNKIVKNAIENLHKQKP
CCCCCEEEEEECCCCHHCCHHEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PPLSCPDKANFITIGTLEHDLDLITECDLIIEVIVEKLEIKHQLYNKLIPYLKEEAIIAS
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEC
NTSTLPLKRLKENLPDNIKSRFVITHFFNPPRYMELLELIIDHMVKVEAIERVSEFLTKT
CCCCCCHHHHHHCCCCCHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTIVRCNDTPGFIANRVGCFLLELVVRKAISQKLNFVALDKIFTTCLGLPSTGIFGLY
HHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHH
DLIGHDVMKLISSSLLAALPAKDAYHKIYVNTPVLDKMIGRKLIGRKGCGGFYRLSVSNG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCC
KKIQEVININDLSYSPVQKVDISFKNLDELLASDSVYGKFFTEIITEFYVYLASLVPSVT
HHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DNIYDIDAAMKLGYSWKYGPFELLTIAAKDGWNSIIKNTDLMHIPLPQYLGNKEYQKIDK
CCCEEHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHCCCCEEEECCHHHHCCHHHHHHHH
QKFNSHKDILKESQIVLENDSAKLINYRENLVFVITTKMNCLNHNVFYLLQEAASKAEND
HHCCCHHHHHHCCCEEEECCCCCEEEECCCEEEEEEECHHHHCCHHHHHHHHHHHHCCCC
GKNLYIYPQGNHFSAGADLKLLLSYIEDKNFHDLENLLKLGQQTMLHLKYSAAHIVSCAK
CCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVALGGGCELLLYSSYIVANNELSAGLVELGVGLIPGWGGVTVMFARARGDKTKLIRNVR
CCEECCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
NIIEQNKTSSADYVKADYDVENMQVNMNKHYILDEALKLNLSKKIVPATHKVTLPKINLA
HHHHCCCCCCCCCEEECCCCCCEEEECCCCEEHHHHHHCCCCCCCCCCCCEEECCCCCCE
TEIDISKYNDLQNKVLSKFQTIIDQHNETNEESLFAYERDIFLELAKDPKTIEKLKVVLG
EEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
H
C
>Mature Secondary Structure
MQNEIKKICVIGSGVMGSGIAALIANSSHKVVLLDIIAKDSDDPNKIVKNAIENLHKQKP
CCCCCEEEEEECCCCHHCCHHEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PPLSCPDKANFITIGTLEHDLDLITECDLIIEVIVEKLEIKHQLYNKLIPYLKEEAIIAS
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEC
NTSTLPLKRLKENLPDNIKSRFVITHFFNPPRYMELLELIIDHMVKVEAIERVSEFLTKT
CCCCCCHHHHHHCCCCCHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTIVRCNDTPGFIANRVGCFLLELVVRKAISQKLNFVALDKIFTTCLGLPSTGIFGLY
HHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHH
DLIGHDVMKLISSSLLAALPAKDAYHKIYVNTPVLDKMIGRKLIGRKGCGGFYRLSVSNG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCC
KKIQEVININDLSYSPVQKVDISFKNLDELLASDSVYGKFFTEIITEFYVYLASLVPSVT
HHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DNIYDIDAAMKLGYSWKYGPFELLTIAAKDGWNSIIKNTDLMHIPLPQYLGNKEYQKIDK
CCCEEHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHCCCCEEEECCHHHHCCHHHHHHHH
QKFNSHKDILKESQIVLENDSAKLINYRENLVFVITTKMNCLNHNVFYLLQEAASKAEND
HHCCCHHHHHHCCCEEEECCCCCEEEECCCEEEEEEECHHHHCCHHHHHHHHHHHHCCCC
GKNLYIYPQGNHFSAGADLKLLLSYIEDKNFHDLENLLKLGQQTMLHLKYSAAHIVSCAK
CCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVALGGGCELLLYSSYIVANNELSAGLVELGVGLIPGWGGVTVMFARARGDKTKLIRNVR
CCEECCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
NIIEQNKTSSADYVKADYDVENMQVNMNKHYILDEALKLNLSKKIVPATHKVTLPKINLA
HHHHCCCCCCCCCEEECCCCCCEEEECCCCEEHHHHHHCCCCCCCCCCCCEEECCCCCCE
TEIDISKYNDLQNKVLSKFQTIIDQHNETNEESLFAYERDIFLELAKDPKTIEKLKVVLG
EEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA