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The map label for this gene is clpP

Identifier: 157825907

GI number: 157825907

Start: 759326

End: 759931

Strand: Reverse

Name: clpP

Synonym: A1C_04235

Alternate gene names: 157825907

Gene position: 759931-759326 (Counterclockwise)

Preceding gene: 157825908

Following gene: 157825906

Centisome position: 61.73

GC content: 36.14

Gene sequence:

>606_bases
ATGTCGTATGTACCGATAGTAATTGAGCAAACCTCTCGAGGTGAGCGTGCTTATGATATATATTCAAGATTGCTAAAAGA
GCGTATAATCTTTGTATGTAGCACTGTTGAAGATCATATGGCCAACTTAATTGTTGCACAGTTATTGTTTCTTGAAGCAG
AAAATCCTAAAAAAGATGTATATATGTATATCAATTCCCCTGGAGGAGTTGTAACCGCAGGTCTTGCGATTTATGACACA
ATGCAATATATAAAACCTAAAGTGGCAACGCTTTGCATCGGTCAAGCGTGTTCTATGGGTTCACTTTTACTTTGTGGAGG
CACGCAGGGGATGCGTTATAGTTTACCTCATAGCCGTATTATGATCCATCAACCGTCAGGAGGTTATAAAGGGCAAGCTA
CCGATATAGAAATCCATGCTCAAGAAACTCTAAAAATCAAAAGGTTACTTAACGAATTGTATAGTAAACATACTGGACAA
GAGTTAAAACATATCGAAAAAAGTATGGAACGTGATAATTTCATGTCACCGGAAGAAGCAAAGAAATTTGGAATAATTGA
TAATATAATTTCTTCTAGAGATGTTATGACAATGTCAGCAAAATAA

Upstream 100 bases:

>100_bases
TTACAGTTTTTCCTCGCAATGACGAGTTTCAAGACCCACGCAGACCACGTGCGCTTGCAATGACAAAATATCATATAATT
AGTCTAAGGAGAAAATATTA

Downstream 100 bases:

>100_bases
AGAATTAGTATTGCTACTCAATATAGATTCGTCATTACGAAGCCACGAAGTGGCTGTGGCAATCCAGAACAATAATAAAA
AGTGCTAATTTTAATATTTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDVYMYINSPGGVVTAGLAIYDT
MQYIKPKVATLCIGQACSMGSLLLCGGTQGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTGQ
ELKHIEKSMERDNFMSPEEAKKFGIIDNIISSRDVMTMSAK

Sequences:

>Translated_201_residues
MSYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDVYMYINSPGGVVTAGLAIYDT
MQYIKPKVATLCIGQACSMGSLLLCGGTQGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTGQ
ELKHIEKSMERDNFMSPEEAKKFGIIDNIISSRDVMTMSAK
>Mature_200_residues
SYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDVYMYINSPGGVVTAGLAIYDTM
QYIKPKVATLCIGQACSMGSLLLCGGTQGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTGQE
LKHIEKSMERDNFMSPEEAKKFGIIDNIISSRDVMTMSAK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=64.2105263157895, Blast_Score=266, Evalue=1e-71,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=66.4948453608247, Blast_Score=291, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=58.0645161290323, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=63.6842105263158, Blast_Score=266, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_RICAH (A8GNZ4)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493627.1
- ProteinModelPortal:   A8GNZ4
- SMR:   A8GNZ4
- STRING:   A8GNZ4
- MEROPS:   S14.001
- GeneID:   5645588
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_04235
- NMPDR:   fig|293614.3.peg.793
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   RAKA293614:A1C_04235-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22598; Mature: 22466

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDV
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YMYINSPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGTQGMRYSLPHSRI
EEEECCCCCEEEHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCEE
MIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTGQELKHIEKSMERDNFMSPEEA
EEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
KKFGIIDNIISSRDVMTMSAK
HHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure 
SYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDV
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YMYINSPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGTQGMRYSLPHSRI
EEEECCCCCEEEHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCEE
MIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTGQELKHIEKSMERDNFMSPEEA
EEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
KKFGIIDNIISSRDVMTMSAK
HHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA