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The map label for this gene is thrS [H]

Identifier: 157825427

GI number: 157825427

Start: 306467

End: 308374

Strand: Direct

Name: thrS [H]

Synonym: A1C_01640

Alternate gene names: 157825427

Gene position: 306467-308374 (Clockwise)

Preceding gene: 157825426

Following gene: 157825428

Centisome position: 24.89

GC content: 38.47

Gene sequence:

>1908_bases
ATGATAAATATTTCTTTTCCCGACGGTAGTGTAAGACAATTTGAAAACGATATTACAGCCTATGAAGTAGCAAATGCAAT
TTCAATGTCACTGGCTAAAGCAGCAATGGTTGCTGAAATAAATGGCGAGCTTAAAGATTTAAGTACCGTAATTGAAAATG
ATTGCAAGCTTCGTATTTTAACTGCAAAAGATTCTGAATGTCTTGAGATCATAAGGCACGATGCGGCTCATATTATAGCT
GAAGCTGCTAAAGAATTATTTCCTGATATTCAAGTAACTATCGGTCCTGCAATTGAAAACGGTTTCTTTTACGATTTTGC
TAAGGATAAGCCATTTACACCAGATGATGTGGCAATGATAGAAGCAAGAATGCATGAAATAGTCAAGCGAAACGAACAAA
TTACTAGAGAATTATGGAATCGTGATAAAGCCATTGAGTTTTTTAAATCGATAGGGGAGCACTATAAAGCCGAAATTATT
GCTTCAATTCCTGCAGGTGAGCAGATTACTTTATACAGGCAAGGTAATTTTATTGATTTATGTCGAGGCCCGCATGCTCC
TTCCACAGGTTTCGTTAAGCATTTTAAGTTGATGAAAGTTGCAGGAGCTTATTGGCGAGGTGATAGTCGTAATGAGATGT
TGCAGCGTATATACGGTACGGCGTGGGCTACGAAAGAGCAGCTCGATAATTACCTCTTGATGCTTGAAGAAGCCGAGAAA
CGTGATCATAGAAAGCTAGGGAAAGAGCTTGATTTATTCCACTTCCAAGAAGAAGCTCAAGGGATGGTATTTTGGCATGA
TAAAGGTTGGAGTATATATAATACCATTGAGCAGTATATTAGGAAAAAGATTCGTAAAAACGGTTATACTGAGGTTAAAA
CACCTGTTTTAGTCGATAAAAGTCTTTGGGAAGCTTCAGGACATTGGGAAAAGTTTCGTGACGATATGTTTGCGTTAGAC
ACAGATGACAAGACGCTTGCTTTAAAGCCTATGAATTGCCCTTGCCACGTGCAGATATTTAAACAAGGTATCAAGAGCTA
TCGTGATTTACCGCTACGTATGTCTGAGTTTGGTTTATGTCATCGTAATGAGGCATCCGGTGCGTTGCACGGTTTAATGA
GAGTGCGGAGTTTAGTACAAGACGATGCACATATATTTTGTACAGAGGAACAAATTACCGATGAAACGGTTAGTTTTTGT
AAATTACTGACGGAAGTTTATAAAGATTTTGGTTTTACCAATATAAGTGTAAAATTCTCTGATCGTCCTGAGGTTAGAGC
CGGTAGCAATGGGACGTGGGATAAGGCAGAGAATGCTTTAAAAGAAGCAGTGGAAAAAGCAGGGTTTACTTACACGCTAA
ACCCGGGTGAAGGTGCATTTTACGGTCCGAAGCTTGAGTTTGTTTTAACCGATGCGATAGGACGGCAGTGGCAATGCGGT
ACACTTCAGATGGATTTTGTTTTGCCGGAGCGACTCGATGCTAGCTATATTGCAGCAAGCGGTGAGAAAAAAAGACCGGT
AATGCTCCATAGGGCAATACTAGGCTCGCTTGAGCGTTTTATTGGTATATTGATTGAAGAATATGCTGGGTGTTTTCCTC
TTTGGCTTGCTCCTATACAAGTTGCTATTGCAACAATTACAAGTGATTTAAACGATTACGCTTTAGAAGTGCAAAAAGCT
TTAATTGATAATGGTGTAAGAACGGATATTAATATCTCACCTGATAAAATTAACTATAAGATTCGTGAGTTTTATAATCA
AAAAATACCTATGATTGCTGTAATCGGTAAACAAGAGCAAGAAAATAAACAAGTAACGATAAGAAGACTCAGAACTACCG
AGCAGGAAGTATTATCGCTCGAACAGTTGATAACATTAATTAAGGAAGAGAATGAGAAGTATTTGTAA

Upstream 100 bases:

>100_bases
GTCATCCCGTGGTTTGACTCACTGGATGACAGCGGATTGTTTAAGAATCATATCGGCAACGTCTAAAATAGAAACCTAGA
AAAAATAAGTTATAATAAAA

Downstream 100 bases:

>100_bases
TATATATGAAATTTAGAATTGTTTAAGACAACATAATGTTGCGATGTCATTCCTGCGTAAGCAGGAATCCAGTTACCATT
AATGTCATACCGCGACTTGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MINISFPDGSVRQFENDITAYEVANAISMSLAKAAMVAEINGELKDLSTVIENDCKLRILTAKDSECLEIIRHDAAHIIA
EAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMIEARMHEIVKRNEQITRELWNRDKAIEFFKSIGEHYKAEII
ASIPAGEQITLYRQGNFIDLCRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLLMLEEAEK
RDHRKLGKELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDKSLWEASGHWEKFRDDMFALD
TDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLCHRNEASGALHGLMRVRSLVQDDAHIFCTEEQITDETVSFC
KLLTEVYKDFGFTNISVKFSDRPEVRAGSNGTWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCG
TLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGCFPLWLAPIQVAIATITSDLNDYALEVQKA
LIDNGVRTDINISPDKINYKIREFYNQKIPMIAVIGKQEQENKQVTIRRLRTTEQEVLSLEQLITLIKEENEKYL

Sequences:

>Translated_635_residues
MINISFPDGSVRQFENDITAYEVANAISMSLAKAAMVAEINGELKDLSTVIENDCKLRILTAKDSECLEIIRHDAAHIIA
EAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMIEARMHEIVKRNEQITRELWNRDKAIEFFKSIGEHYKAEII
ASIPAGEQITLYRQGNFIDLCRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLLMLEEAEK
RDHRKLGKELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDKSLWEASGHWEKFRDDMFALD
TDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLCHRNEASGALHGLMRVRSLVQDDAHIFCTEEQITDETVSFC
KLLTEVYKDFGFTNISVKFSDRPEVRAGSNGTWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCG
TLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGCFPLWLAPIQVAIATITSDLNDYALEVQKA
LIDNGVRTDINISPDKINYKIREFYNQKIPMIAVIGKQEQENKQVTIRRLRTTEQEVLSLEQLITLIKEENEKYL
>Mature_635_residues
MINISFPDGSVRQFENDITAYEVANAISMSLAKAAMVAEINGELKDLSTVIENDCKLRILTAKDSECLEIIRHDAAHIIA
EAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMIEARMHEIVKRNEQITRELWNRDKAIEFFKSIGEHYKAEII
ASIPAGEQITLYRQGNFIDLCRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLLMLEEAEK
RDHRKLGKELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDKSLWEASGHWEKFRDDMFALD
TDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLCHRNEASGALHGLMRVRSLVQDDAHIFCTEEQITDETVSFC
KLLTEVYKDFGFTNISVKFSDRPEVRAGSNGTWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCG
TLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGCFPLWLAPIQVAIATITSDLNDYALEVQKA
LIDNGVRTDINISPDKINYKIREFYNQKIPMIAVIGKQEQENKQVTIRRLRTTEQEVLSLEQLITLIKEENEKYL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=612, Percent_Identity=39.8692810457516, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI38202255, Length=633, Percent_Identity=39.1785150078989, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI20070344, Length=628, Percent_Identity=38.5350318471338, Blast_Score=433, Evalue=1e-121,
Organism=Escherichia coli, GI1788013, Length=631, Percent_Identity=50.7131537242472, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=158, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71984184, Length=638, Percent_Identity=40.5956112852665, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71984192, Length=638, Percent_Identity=40.5956112852665, Blast_Score=502, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322112, Length=651, Percent_Identity=38.0952380952381, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322654, Length=458, Percent_Identity=36.2445414847162, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24583839, Length=637, Percent_Identity=39.8744113029827, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583842, Length=637, Percent_Identity=39.8744113029827, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI28574141, Length=637, Percent_Identity=39.8744113029827, Blast_Score=492, Evalue=1e-139,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72690; Mature: 72690

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINISFPDGSVRQFENDITAYEVANAISMSLAKAAMVAEINGELKDLSTVIENDCKLRIL
CEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEE
TAKDSECLEIIRHDAAHIIAEAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMI
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHH
EARMHEIVKRNEQITRELWNRDKAIEFFKSIGEHYKAEIIASIPAGEQITLYRQGNFIDL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCEEEE
CRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLLMLEEAEK
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDK
HHHHHHCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECH
SLWEASGHWEKFRDDMFALDTDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLC
HHHHCCCCHHHHHCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHCCCC
HRNEASGALHGLMRVRSLVQDDAHIFCTEEQITDETVSFCKLLTEVYKDFGFTNISVKFS
CCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DRPEVRAGSNGTWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEEEEEEHHCCCCCCCC
TLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGCFPLWLAPIQ
CEEEEEECCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VAIATITSDLNDYALEVQKALIDNGVRTDINISPDKINYKIREFYNQKIPMIAVIGKQEQ
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
ENKQVTIRRLRTTEQEVLSLEQLITLIKEENEKYL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MINISFPDGSVRQFENDITAYEVANAISMSLAKAAMVAEINGELKDLSTVIENDCKLRIL
CEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEE
TAKDSECLEIIRHDAAHIIAEAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMI
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHH
EARMHEIVKRNEQITRELWNRDKAIEFFKSIGEHYKAEIIASIPAGEQITLYRQGNFIDL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCEEEE
CRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLLMLEEAEK
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDK
HHHHHHCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECH
SLWEASGHWEKFRDDMFALDTDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLC
HHHHCCCCHHHHHCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHCCCC
HRNEASGALHGLMRVRSLVQDDAHIFCTEEQITDETVSFCKLLTEVYKDFGFTNISVKFS
CCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DRPEVRAGSNGTWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEEEEEEHHCCCCCCCC
TLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGCFPLWLAPIQ
CEEEEEECCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VAIATITSDLNDYALEVQKALIDNGVRTDINISPDKINYKIREFYNQKIPMIAVIGKQEQ
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
ENKQVTIRRLRTTEQEVLSLEQLITLIKEENEKYL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA