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The map label for this gene is pqqL [C]

Identifier: 157825424

GI number: 157825424

Start: 302409

End: 303647

Strand: Direct

Name: pqqL [C]

Synonym: A1C_01625

Alternate gene names: 157825424

Gene position: 302409-303647 (Clockwise)

Preceding gene: 157825423

Following gene: 157825425

Centisome position: 24.56

GC content: 31.8

Gene sequence:

>1239_bases
ATGAAAGAAAATTTTAACGTTAGTAAATTAAAAAACGGTTTAACAATTTTAACCTATAATATGCCTTATGTTAATTCGGT
AGCAATAAATTTAATTGCTAAAGTTGGAGCACGTTATGAGAATGCAGAAGAGGAAGGTATCTCTCACTTTCTTGAGCATA
TGGCTTTTAAAGGTACAAAAACTAGAACGGCAAAACAGATAGCAGAAGAGTTTGACTCTATAGGCGGACATTTTAATGCC
TATACCGGTCATGAGAATACGGTATATTATGTACGAGTCTTGTCTGAAAATTGTGATAAAGCAGTTAACATACTTGCCGA
TATAATTCAAAATTCTATTTTTGCTGACGAAGAAATAGCTAAGGAATATCAGGTGATAATGCAGGAAATTGCTCATCATC
AGGATAATCCAGATGACCTAGTATATGAAAAGTTTTATAATAAAGTTTATAGAGATCAACCGTTAGGTAAGTTGATCTTA
GGTACTACTAAAACCATTGCAGCTTTTACGCAAGAGCATTTTTTGACCTTTATAGGTAAACATTATAATGCTGAAAATCT
TTATTTATCGATTGCCGGTAATATTGATCATGATAAAATAGTAATTATAGCGGAACAGTTATTTTCTTCTTTGAAGCAAG
GAGTAAAAAGTAGCTTTATTCCGGCAAAATATATAGGTGGAAATGGCTTTATTCATAAGGAGTTAGAACAAACTAGTTTA
GTGCTAGGGTTTGAAGGTACATCATATATTAATTTAGAAAAGCTGTACCAAACCCATCTACTTTCTATAATATTCGGCGG
CGGTATGTCATCGCGTTTATTTCAAACTATTCGTGAGAAATTGGGGTTAGCATATGCAGTAGGTAGTTATAATAGTGCTT
ACTTTGATAGTGGAGTGTTTACAATTTATGCGTCTACTGCACATGATAAATTAGAATTATTATATCGAGAGATTAAAAAC
GAAATAATAAAAATGACTGAAACAGTAAGTGCAGAAGAGATTATTAGAGCTAAAACACAACTTCGTAGTAATTTACAAAT
GGCTCAAGAGAAAAATGCTTATAAGTCAGAAGAAATAGGTAAAAATTATTCTGTTTTCGGTAAATATATTTCTCCTGAGG
AGATTATGGAAATTATTACAAATATAAAAACCGATGACATTATTAATACTGCAAATAAAATATTTAGCGGTACTACTACG
TCGGCAATTATTGGTCCGAATGGTTTGAGAGAGGTTTAA

Upstream 100 bases:

>100_bases
GCTTCGTCGAATTACTACATAATTCTTCTACCAATGACGGAAAACCGATCCACGTAATAATGTCTACTCACAATGATGAT
TTAGAAAATAAAAGTAACTT

Downstream 100 bases:

>100_bases
TGTCATTCCTGCAAAAGCAGGAATGACATATGTATCCACGCAGGCGATGACGAGGACAATGAATTTTGAGAAAATAACAA
ATGAAAACACAAATTTACAA

Product: mitochondrial protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEEGISHFLEHMAFKGTKTRTAKQIAEEFDSIGGHFNA
YTGHENTVYYVRVLSENCDKAVNILADIIQNSIFADEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYRDQPLGKLIL
GTTKTIAAFTQEHFLTFIGKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNGFIHKELEQTSL
VLGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQTIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKN
EIIKMTETVSAEEIIRAKTQLRSNLQMAQEKNAYKSEEIGKNYSVFGKYISPEEIMEIITNIKTDDIINTANKIFSGTTT
SAIIGPNGLREV

Sequences:

>Translated_412_residues
MKENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEEGISHFLEHMAFKGTKTRTAKQIAEEFDSIGGHFNA
YTGHENTVYYVRVLSENCDKAVNILADIIQNSIFADEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYRDQPLGKLIL
GTTKTIAAFTQEHFLTFIGKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNGFIHKELEQTSL
VLGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQTIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKN
EIIKMTETVSAEEIIRAKTQLRSNLQMAQEKNAYKSEEIGKNYSVFGKYISPEEIMEIITNIKTDDIINTANKIFSGTTT
SAIIGPNGLREV
>Mature_412_residues
MKENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEEGISHFLEHMAFKGTKTRTAKQIAEEFDSIGGHFNA
YTGHENTVYYVRVLSENCDKAVNILADIIQNSIFADEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYRDQPLGKLIL
GTTKTIAAFTQEHFLTFIGKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNGFIHKELEQTSL
VLGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQTIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKN
EIIKMTETVSAEEIIRAKTQLRSNLQMAQEKNAYKSEEIGKNYSVFGKYISPEEIMEIITNIKTDDIINTANKIFSGTTT
SAIIGPNGLREV

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=417, Percent_Identity=28.7769784172662, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI46593007, Length=419, Percent_Identity=24.1050119331742, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI24308013, Length=430, Percent_Identity=25.5813953488372, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI50592988, Length=413, Percent_Identity=26.634382566586, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1787770, Length=213, Percent_Identity=27.6995305164319, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999683, Length=412, Percent_Identity=29.126213592233, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17553678, Length=377, Percent_Identity=24.4031830238727, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510601, Length=439, Percent_Identity=22.3234624145786, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323192, Length=404, Percent_Identity=33.6633663366337, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6321813, Length=426, Percent_Identity=25.3521126760563, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21357875, Length=411, Percent_Identity=29.4403892944039, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24646943, Length=411, Percent_Identity=29.4403892944039, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI19921772, Length=435, Percent_Identity=24.367816091954, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46415; Mature: 46415

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEEGISHFLEHMAFKGTK
CCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
TRTAKQIAEEFDSIGGHFNAYTGHENTVYYVRVLSENCDKAVNILADIIQNSIFADEEIA
HHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHCCCCHHHH
KEYQVIMQEIAHHQDNPDDLVYEKFYNKVYRDQPLGKLILGTTKTIAAFTQEHFLTFIGK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHC
HYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNGFIHKELEQTSL
CCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCEE
VLGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQTIREKLGLAYAVGSYNSAYFDSGVF
EEEECCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHCCCCEE
TIYASTAHDKLELLYREIKNEIIKMTETVSAEEIIRAKTQLRSNLQMAQEKNAYKSEEIG
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
KNYSVFGKYISPEEIMEIITNIKTDDIINTANKIFSGTTTSAIIGPNGLREV
CCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MKENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEEGISHFLEHMAFKGTK
CCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
TRTAKQIAEEFDSIGGHFNAYTGHENTVYYVRVLSENCDKAVNILADIIQNSIFADEEIA
HHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHCCCCHHHH
KEYQVIMQEIAHHQDNPDDLVYEKFYNKVYRDQPLGKLILGTTKTIAAFTQEHFLTFIGK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHC
HYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNGFIHKELEQTSL
CCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCEE
VLGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQTIREKLGLAYAVGSYNSAYFDSGVF
EEEECCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHCCCCEE
TIYASTAHDKLELLYREIKNEIIKMTETVSAEEIIRAKTQLRSNLQMAQEKNAYKSEEIG
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
KNYSVFGKYISPEEIMEIITNIKTDDIINTANKIFSGTTTSAIIGPNGLREV
CCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]