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The map label for this gene is gyrA [H]

Identifier: 157825406

GI number: 157825406

Start: 280551

End: 283247

Strand: Direct

Name: gyrA [H]

Synonym: A1C_01525

Alternate gene names: 157825406

Gene position: 280551-283247 (Clockwise)

Preceding gene: 157825405

Following gene: 157825408

Centisome position: 22.79

GC content: 38.64

Gene sequence:

>2697_bases
GTGACTGATAAATATTCTTCTAATTTAGTGCCGGTAAATATCGAAGATGAGATGAAAGTATCTTATCTTGATTATGCTAT
GAGCGTTATAGTAAGTAGAGCTATACCGGATGTTCGGGACGGCTTAAAGCCGGTACATCGCCGAATTATCTATTCCATGC
ATGAAGCCGGTAATCATGCTAGCAAACCTTATAGAAAATCCGCAAGAATAGTTGGTGACGTGATGGGTAAATACCATCCG
CACGGTGATAGTGCTATTTATGATTCGTTAGTACGTATGGCACAAGCCTTTTCCTTGCGTTTGCCACTTGTCGACGGGCA
AGGTAATTTTGGATCGATGGATGGTGATGCAGCGGCAGCGATGAGATATACCGAATCTCGAATGGCCAAAGTTTCGCATA
AGCTCGTAGAGGATATCGATAAAGAGACTGTTAGCTTTAACCCTAATTATGACGGTTCTGAAAAAGAGCCTTCCGTACTT
CCTGCAATGTTTCCAAATTTATTGGTTAACGGTAGTGGAGGTATTGCGGTCGGTATGGCAACTAATATCCCTCCTCATAA
TCTTGGTGAGGTTATCGATGCGTGCTGTTTATATATAGATAATAATGATATAGAAATATTAGATTTACTCGAAGTCGTTA
AAGGACCGGATTTTCCTACAGGTTCAATGATTTTAGGTATTAGCGGTATTAGATCGGCATATCTTACCGGTAGAGGTAGT
ATCATTATGCGAGGTCGAGCCGAGATTGAGAATATCGGTAATAGCCGTCAAGCAATTATTATTACCGAAATACCGTATAT
GGTAAATAAGGCCAGGCTCGTTGAGAAAATTGCTGAAATGGTTAAGGAAAAGCGAATAGAAGGTATAAGTGATTTACGTG
ACGAATCGAATAAAAACGGTGTAAGGATTTTTATTGAGTTAAAGAAAGACGTAGTTGCGGAAGTAGTCTTAAATCAAATA
TACGCATGTACGCAGTTACAAACTAGCTTCGGTGTTATTATGCTTGCTCTTAAAGACGGGCTACCGAAAGTGATGAATTT
GAAAGAAGTAATTGCGGCTTTCGTTAGTTTTAGAGAAGTGGTAATTACTAACCGTACTATATATTTACTAAATAAAGCAA
GAGATAAAGCACATATTTTACTAGGACTAACTATTGCCGTTAGTAATATCGATGAAATAATACGTATTATTAAAGCTGCA
AATGACACGAATGCAGCTAAACAAGAATTAATGGCACGCAGCTGGGAAGCATTAAAGATCCTACCTCTTGTAAAGCTGGT
TGATGATAAGGCAATGTTAAATGAGCAAGACAAATGTAGTTTTACTGAGTTGCAAGCTAAGGCAATCTTAGAAATGAGAC
TACAGCGTCTAACCGCTATGGAGAAAAACAAGCTTGAAGAGGAGTTAAAGAACCTCGCTACGGAGATCACAGAATATATT
AATATACTCGGCTCTCGTACGAGATTACTTGAAATTTTAAAAGAAGAGTTAATTAAAGTTAAAGAAGAGTTTGCGACTCC
TCGTCTGACTTCAATTGAATTCGGTGAGTTTGATCAAGATATAGAAGATTTAATTCAACGTGAAGAAATGGTAGTAACAG
TAACGCTTGGTGGGTATATCAAGCGTGTACCTCTAAGTAGCTATCGTTCACAAAAACGAGGCGGTAAAGGAAGATCCGGG
CTTTCAATGCGTGATGAAGATATTACCACGCGAATTTTTGTCGGTAGTACTCATACTCCGATGTTGTTCTTCTCAAATAT
CGGTCAGGTTTATAGTTTAAAACTGTATAAATTACCTTTAAGTAATCCGCAAGGTAAAGGAAGACCAATGGTTAATATAT
TACCGCTGAAAGAAAATGAGCATATTACGAATATTATGCCGCTACCTGAAAATCAGGATGAATGGGATAATTTAAACATT
ATGTTCGCAACTGCAAAGGGTAATATCAGAAGAAGCGATTTATTAGATTTTAAAAAGATTCAGTCGAGCGGTAAAATTGC
TATTAGGCTTGATGATGATGATAAATTAATAGACGTAAAACCATGTAAAGAAGACGAGCACATTTTACTTGCCACTAAAG
CCGGTAAAGCTTTAAGATTCCCTGTTGAATCGCTGCGTGTTATTAAGAGCCGTACTTCCGACGGGGTACGAGGTATGAAA
CTTGCTAAGGAGGATTCCGTAATTTCTATGACCGTGCTTAAAGGCATTAACAGTACAAAAGAGGATAGAGATGCTTATTT
CACAGTGCCATGGGCAAAAAGGCTTGAGATTGCGAAAGGTGAGGAGTTTAACCTCGAAGAGTTAGGTGTAACTTTGACTG
CAGATTCTATTTTAAAAATGGCAAATTCCGAAGAATTCATCTTAACAGTTACAGAGAACGGTTTCGGAAAAAGAAGCTCG
GCATATGGCTATAGAATTACCGATCGAGGCGGTAGCGGCATAATCAATATGGATATTAACGACAAAACCGGCTTGGTCGT
CGGTGTTATGCCGGTTAAAATAGATGATGAGCTAATGCTGATTACCAATAGCGGTAAGTTAATTCGCTGTAAACTTGAGT
CAGTGCGTATTACGGGACGTAACACTAGCGGCGTAATCCTATTTAAGTTAGATGACGGTGAAAAAGTCGTATCTGTCTCT
TTAATTGCTGAAACTTCTGAAAGCGCAGAAGATAGTGAGTTAGAGGAAGATGGGTAG

Upstream 100 bases:

>100_bases
TAGAAACAATGTAACAATTATAAATACACGCAATCCTTGAAAGAAATTTATTATGTCTCTATAATTAAATATGATTTATT
AAATTTAAGGCTAAGTAATC

Downstream 100 bases:

>100_bases
TAGTTGTTAAGTTGGATGGTTATGTTGTTTTTGTAAAAAGACTCCAAGTGTTTCAGTGTCATACCGCGACTTGATCGCTG
TATCCAGTTAAAAATACTGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 898; Mature: 897

Protein sequence:

>898_residues
MTDKYSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHP
HGDSAIYDSLVRMAQAFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSHKLVEDIDKETVSFNPNYDGSEKEPSVL
PAMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
IIMRGRAEIENIGNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQI
YACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAA
NDTNAAKQELMARSWEALKILPLVKLVDDKAMLNEQDKCSFTELQAKAILEMRLQRLTAMEKNKLEEELKNLATEITEYI
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRSQKRGGKGRSG
LSMRDEDITTRIFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKENEHITNIMPLPENQDEWDNLNI
MFATAKGNIRRSDLLDFKKIQSSGKIAIRLDDDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
LAKEDSVISMTVLKGINSTKEDRDAYFTVPWAKRLEIAKGEEFNLEELGVTLTADSILKMANSEEFILTVTENGFGKRSS
AYGYRITDRGGSGIINMDINDKTGLVVGVMPVKIDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVS
LIAETSESAEDSELEEDG

Sequences:

>Translated_898_residues
MTDKYSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHP
HGDSAIYDSLVRMAQAFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSHKLVEDIDKETVSFNPNYDGSEKEPSVL
PAMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
IIMRGRAEIENIGNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQI
YACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAA
NDTNAAKQELMARSWEALKILPLVKLVDDKAMLNEQDKCSFTELQAKAILEMRLQRLTAMEKNKLEEELKNLATEITEYI
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRSQKRGGKGRSG
LSMRDEDITTRIFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKENEHITNIMPLPENQDEWDNLNI
MFATAKGNIRRSDLLDFKKIQSSGKIAIRLDDDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
LAKEDSVISMTVLKGINSTKEDRDAYFTVPWAKRLEIAKGEEFNLEELGVTLTADSILKMANSEEFILTVTENGFGKRSS
AYGYRITDRGGSGIINMDINDKTGLVVGVMPVKIDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVS
LIAETSESAEDSELEEDG
>Mature_897_residues
TDKYSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHPH
GDSAIYDSLVRMAQAFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSHKLVEDIDKETVSFNPNYDGSEKEPSVLP
AMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGSI
IMRGRAEIENIGNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQIY
ACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAAN
DTNAAKQELMARSWEALKILPLVKLVDDKAMLNEQDKCSFTELQAKAILEMRLQRLTAMEKNKLEEELKNLATEITEYIN
ILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRSQKRGGKGRSGL
SMRDEDITTRIFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKENEHITNIMPLPENQDEWDNLNIM
FATAKGNIRRSDLLDFKKIQSSGKIAIRLDDDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMKL
AKEDSVISMTVLKGINSTKEDRDAYFTVPWAKRLEIAKGEEFNLEELGVTLTADSILKMANSEEFILTVTENGFGKRSSA
YGYRITDRGGSGIINMDINDKTGLVVGVMPVKIDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSL
IAETSESAEDSELEEDG

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=343, Percent_Identity=24.4897959183673, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=351, Percent_Identity=24.7863247863248, Blast_Score=78, Evalue=5e-14,
Organism=Escherichia coli, GI1788562, Length=889, Percent_Identity=48.4814398200225, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=731, Percent_Identity=34.8837209302326, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI212645845, Length=459, Percent_Identity=25.4901960784314, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=171, Percent_Identity=30.4093567251462, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=164, Percent_Identity=31.0975609756098, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=284, Percent_Identity=26.056338028169, Blast_Score=71, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 100025; Mature: 99894

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKYSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHA
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SKPYRKSARIVGDVMGKYHPHGDSAIYDSLVRMAQAFSLRLPLVDGQGNFGSMDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHH
MRYTESRMAKVSHKLVEDIDKETVSFNPNYDGSEKEPSVLPAMFPNLLVNGSGGIAVGMA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCEEEEEE
TNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
CCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHEEECCCC
IIMRGRAEIENIGNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNG
EEEECCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VRIFIELKKDVVAEVVLNQIYACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHCHHHHHHHHHHHHHH
VITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAANDTNAAKQELMARSWEALKI
EEECCEEEEEECCCCCEEEEEEEEEEHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
LPLVKLVDDKAMLNEQDKCSFTELQAKAILEMRLQRLTAMEKNKLEEELKNLATEITEYI
HHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYI
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCEE
KRVPLSSYRSQKRGGKGRSGLSMRDEDITTRIFVGSTHTPMLFFSNIGQVYSLKLYKLPL
EECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEEEEEECC
SNPQGKGRPMVNILPLKENEHITNIMPLPENQDEWDNLNIMFATAKGNIRRSDLLDFKKI
CCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
QSSGKIAIRLDDDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
CCCCCEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCE
LAKEDSVISMTVLKGINSTKEDRDAYFTVPWAKRLEIAKGEEFNLEELGVTLTADSILKM
ECCCCCEEEEEEHHCCCCCCCCCCCEEECCHHHHEEECCCCCCCHHHCCEEEEHHHHHHH
ANSEEFILTVTENGFGKRSSAYGYRITDRGGSGIINMDINDKTGLVVGVMPVKIDDELML
CCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEEEEEEEEECCCEEE
ITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSLIAETSESAEDSELEEDG
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDKYSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SKPYRKSARIVGDVMGKYHPHGDSAIYDSLVRMAQAFSLRLPLVDGQGNFGSMDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHH
MRYTESRMAKVSHKLVEDIDKETVSFNPNYDGSEKEPSVLPAMFPNLLVNGSGGIAVGMA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCEEEEEE
TNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
CCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHEEECCCC
IIMRGRAEIENIGNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNG
EEEECCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VRIFIELKKDVVAEVVLNQIYACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHCHHHHHHHHHHHHHH
VITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAANDTNAAKQELMARSWEALKI
EEECCEEEEEECCCCCEEEEEEEEEEHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
LPLVKLVDDKAMLNEQDKCSFTELQAKAILEMRLQRLTAMEKNKLEEELKNLATEITEYI
HHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYI
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCEE
KRVPLSSYRSQKRGGKGRSGLSMRDEDITTRIFVGSTHTPMLFFSNIGQVYSLKLYKLPL
EECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEEEEEECC
SNPQGKGRPMVNILPLKENEHITNIMPLPENQDEWDNLNIMFATAKGNIRRSDLLDFKKI
CCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
QSSGKIAIRLDDDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
CCCCCEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCE
LAKEDSVISMTVLKGINSTKEDRDAYFTVPWAKRLEIAKGEEFNLEELGVTLTADSILKM
ECCCCCEEEEEEHHCCCCCCCCCCCEEECCHHHHEEECCCCCCCHHHCCEEEEHHHHHHH
ANSEEFILTVTENGFGKRSSAYGYRITDRGGSGIINMDINDKTGLVVGVMPVKIDDELML
CCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEEEEEEEEECCCEEE
ITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSLIAETSESAEDSELEEDG
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA