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The map label for this gene is pepA [H]

Identifier: 157825323

GI number: 157825323

Start: 196090

End: 197574

Strand: Direct

Name: pepA [H]

Synonym: A1C_01025

Alternate gene names: 157825323

Gene position: 196090-197574 (Clockwise)

Preceding gene: 157825321

Following gene: 157825324

Centisome position: 15.93

GC content: 36.9

Gene sequence:

>1485_bases
GTGAATGAAGAATCATCTATTAATCAAGGTCTAGTAGTTTTTATTGATGAACAGTTAAAGCTTGATAGTAATTTAATAGG
ACTTGATCAACAACATCACGGATTAATTGCTAAAACTATTCAGAATAAGCTGCAATTTACCGGTAAATATGGACAAATCA
ATGTGATTCCATCTGTCATTAAATCAGGTGAGGTGAAATATTTGATAATAGTAGGTCTTGGGAATGAAGAAAAATTAACT
GAAGCCAAAATCGAAGAGTTAGGCGGTAAAATCTTACAGCATGCAACCGTTTGTAAAATTTCTACTATCGGCTTAAAACT
TACAAATAGAATTAGTAGGTTTACATCTCAAACATTTGCATCTTTAGTCGCTAGTGGGGCGTTTCTTGCTTCTTACAGAT
TTGATAAATATAGAACTACCTTAAAAGAAGCAGAGAAGTTCGCAGTAGAGTCAATTGAAATTTTTACCGATAATAGCACT
GAAACAGCAAAATTATTTAAAGTTAAAAAATTAATTGCTGAGGCAGTATTTTTTACAAGAGATATATGTAATGAACCGTC
AAATATTAAAACTCCGCAGGTTTATGCTGAAAGAATAGTTGATATACTTGAACCATTTGGAGTAGATGTTGATGTTATCG
GTGAACGTGAGATGAAAAACCTTGGTATGGGTGCATTACTTGGGGTTGGTCAAGGTTCACAAAACGAGTCAAAATTAGTA
GTGATGGAATATAAAGGCGGCAGTAAAGAGGCTCCGATTATTGCTTTGGTTGGTAAAGGAGTGATTTTTGACACCGGTGG
CATTTCATTAAAACCGTCAAGTAATATGCATTTAATGAGATACGATATGGGAGGTTCTGCAGCAGTCGCGGGTGCTATGA
TTGCGGTTGCTGGTCAAAAATTACCTGTAAATATAGTCGGTGTTATAGGGCTTGTAGAAAATATGCCGTCCGGTAATGCA
CAGCGTCCAGGGGATGTGGTAACTACTATGTCAGGGCAAACTGCCGAAGTTTTAAATACCGATGCAGAAGGGCGTTTAGT
ACTTGCTGATGCAGTTTGGTATGCACAAGAAAAATTTAAGCCTAAATACGTGATTGACGTTGCAACTCTAACAGGAGCAA
TAACTGTAGCACTAGGTAGTACATATGCCGGTTGTTTTTCCAATAATGATGAGTTAGCTGATAAGTTAATAAAAGTAGGG
AAAGAAGTTAATGAAAAACTTTGGAGAATGCCTCTGCATGATGAGTACGATGCAATGATTAACTCCGACATAGCCGATAT
GGCAAATATAGGGAACGTACCTGGAGCTGCTGGCAGCTGTATTGCTGCACATTTCATTAAACGTTTCATTAAAGATGGAG
TATATTGGGCTCATTTAGATATAGCAGGCGTTGCAAATAGTAATAAAGCTTCAGCACTCGGTCCGAAAGGGGCAGTGGGG
TATGGTGTTAGATTACTTGAAAAGTTTATCAAAGAATATATTTAA

Upstream 100 bases:

>100_bases
TTTAAATCAATTAATAATACTTGCAAAGCTTTATCAAGATAAATAGAATTGTCCAAAGTCAAAAATAATATCAGGGATAA
GTATGCTTAACATAAACTTT

Downstream 100 bases:

>100_bases
CGTGATTCTTGCTTTTAGTGGCGTTTGTGGCATGGCTCGTTTTTTTGTTGTCATACCATGGCTTGACCGCTGGATCCAAT
AATAATTAAGAACTTTATTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MNEESSINQGLVVFIDEQLKLDSNLIGLDQQHHGLIAKTIQNKLQFTGKYGQINVIPSVIKSGEVKYLIIVGLGNEEKLT
EAKIEELGGKILQHATVCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNST
ETAKLFKVKKLIAEAVFFTRDICNEPSNIKTPQVYAERIVDILEPFGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLV
VMEYKGGSKEAPIIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVAGAMIAVAGQKLPVNIVGVIGLVENMPSGNA
QRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKYVIDVATLTGAITVALGSTYAGCFSNNDELADKLIKVG
KEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVYWAHLDIAGVANSNKASALGPKGAVG
YGVRLLEKFIKEYI

Sequences:

>Translated_494_residues
MNEESSINQGLVVFIDEQLKLDSNLIGLDQQHHGLIAKTIQNKLQFTGKYGQINVIPSVIKSGEVKYLIIVGLGNEEKLT
EAKIEELGGKILQHATVCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNST
ETAKLFKVKKLIAEAVFFTRDICNEPSNIKTPQVYAERIVDILEPFGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLV
VMEYKGGSKEAPIIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVAGAMIAVAGQKLPVNIVGVIGLVENMPSGNA
QRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKYVIDVATLTGAITVALGSTYAGCFSNNDELADKLIKVG
KEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVYWAHLDIAGVANSNKASALGPKGAVG
YGVRLLEKFIKEYI
>Mature_494_residues
MNEESSINQGLVVFIDEQLKLDSNLIGLDQQHHGLIAKTIQNKLQFTGKYGQINVIPSVIKSGEVKYLIIVGLGNEEKLT
EAKIEELGGKILQHATVCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNST
ETAKLFKVKKLIAEAVFFTRDICNEPSNIKTPQVYAERIVDILEPFGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLV
VMEYKGGSKEAPIIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVAGAMIAVAGQKLPVNIVGVIGLVENMPSGNA
QRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKYVIDVATLTGAITVALGSTYAGCFSNNDELADKLIKVG
KEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVYWAHLDIAGVANSNKASALGPKGAVG
YGVRLLEKFIKEYI

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=379, Percent_Identity=39.8416886543536, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI47155554, Length=379, Percent_Identity=32.9815303430079, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1790710, Length=500, Percent_Identity=39.2, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=36, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=349, Percent_Identity=33.810888252149, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17565172, Length=472, Percent_Identity=27.3305084745763, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24662227, Length=513, Percent_Identity=29.4346978557505, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129969, Length=495, Percent_Identity=28.4848484848485, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24661038, Length=512, Percent_Identity=31.640625, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355645, Length=431, Percent_Identity=30.8584686774942, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24662223, Length=431, Percent_Identity=30.8584686774942, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI161077148, Length=352, Percent_Identity=32.1022727272727, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20130057, Length=352, Percent_Identity=32.1022727272727, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129963, Length=461, Percent_Identity=29.5010845986985, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI21355725, Length=378, Percent_Identity=33.5978835978836, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI19922386, Length=477, Percent_Identity=30.6079664570231, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21357381, Length=320, Percent_Identity=35.3125, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI221379063, Length=320, Percent_Identity=35.3125, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI221379062, Length=320, Percent_Identity=35.3125, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24646701, Length=362, Percent_Identity=25.414364640884, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646703, Length=362, Percent_Identity=25.414364640884, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358201, Length=362, Percent_Identity=25.414364640884, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53320; Mature: 53320

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEESSINQGLVVFIDEQLKLDSNLIGLDQQHHGLIAKTIQNKLQFTGKYGQINVIPSVI
CCCCCCCCCCEEEEEECCCCCCCCEECCCCHHCCHHHHHHHHHHHCCCCCCEEEEEHHHH
KSGEVKYLIIVGLGNEEKLTEAKIEELGGKILQHATVCKISTIGLKLTNRISRFTSQTFA
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHH
SLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNSTETAKLFKVKKLIAEAVFFTR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
DICNEPSNIKTPQVYAERIVDILEPFGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLV
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCHHEEECCCCCCCCCEEE
VMEYKGGSKEAPIIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVAGAMIAVAGQK
EEEECCCCCCCCEEEEECCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
LPVNIVGVIGLVENMPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFK
CCEEHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEHHHHHHHHHCC
PKYVIDVATLTGAITVALGSTYAGCFSNNDELADKLIKVGKEVNEKLWRMPLHDEYDAMI
CEEEEEEEHHHCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
NSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVYWAHLDIAGVANSNKASALGPKGAVG
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHH
YGVRLLEKFIKEYI
HHHHHHHHHHHHCC
>Mature Secondary Structure
MNEESSINQGLVVFIDEQLKLDSNLIGLDQQHHGLIAKTIQNKLQFTGKYGQINVIPSVI
CCCCCCCCCCEEEEEECCCCCCCCEECCCCHHCCHHHHHHHHHHHCCCCCCEEEEEHHHH
KSGEVKYLIIVGLGNEEKLTEAKIEELGGKILQHATVCKISTIGLKLTNRISRFTSQTFA
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHH
SLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNSTETAKLFKVKKLIAEAVFFTR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
DICNEPSNIKTPQVYAERIVDILEPFGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLV
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCHHEEECCCCCCCCCEEE
VMEYKGGSKEAPIIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVAGAMIAVAGQK
EEEECCCCCCCCEEEEECCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
LPVNIVGVIGLVENMPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFK
CCEEHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEHHHHHHHHHCC
PKYVIDVATLTGAITVALGSTYAGCFSNNDELADKLIKVGKEVNEKLWRMPLHDEYDAMI
CEEEEEEEHHHCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
NSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVYWAHLDIAGVANSNKASALGPKGAVG
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHH
YGVRLLEKFIKEYI
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA