| Definition | Rickettsia akari str. Hartford, complete genome. |
|---|---|
| Accession | NC_009881 |
| Length | 1,231,060 |
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The map label for this gene is virB4 [H]
Identifier: 157825275
GI number: 157825275
Start: 137496
End: 139913
Strand: Direct
Name: virB4 [H]
Synonym: A1C_00785
Alternate gene names: 157825275
Gene position: 137496-139913 (Clockwise)
Preceding gene: 157825274
Following gene: 157825276
Centisome position: 11.17
GC content: 34.0
Gene sequence:
>2418_bases ATGAAGTTATTTAGAACCAGGGCAGCTAAAGAATTAAGGTCTAAACAAGAAAGACCAACTTCGCATTTTATTCCTTATAA ATGTCATTGGGATAGTAATACTATTTTAACAAAAGATAATTCTTTATTACAAGTTATTAAAATAAACGGATTTTCTTTTG AAACTGCTGATGATGAAGATCTAGACATTAAAAAGAATATCAGAAATGCCTTACTTAAAAATATGGCTTCGGGAAATATC GTTATGTATTTCCATACTATTAGAAGACGTAAAGCGGTAATATTTGACGATACGGAATTTACTTATGATCCTACTGTAAA ACTCCCTAATGATTTCATTACTTATTTAGGTGTAGAATGGCGTAAGAAACATGCGGGTGCTAGGTCATTTTTTAACGAAT TATATGTTAGTATTTTATATAAGCCTGATACAGGTGGTGCTGCTATAGTTGAGTATTTTCTAAAGAAGCTTAGACAAAAA TCTAATAAAACCGCTTGGGAAAATGACATGAAAGAGATGAAAGAAAATCTTCAAGAAATGTCAACTAGAGTGGTTAATAC ATTCAGAAGTTACGGAGCAAGATTACTTGGAGTTCGTCAAACGCAGTCAGGTAATTATTGTGAGATTTTAGAATTCCTTT CATCTTTAATCAATTGCGGTGATTCACCAGGTCCTGTAGCATTACCGCGTGGTACTATTGACGAATATTTACCTACGCAT CGTTTATTTTTTGATTCTCGTACTATTGAAGCAAGAAGTCCGCTTGGCAAAAAATATGCCGGAATGATCAGTATACTTGA ATACGGTCCTAATACTTCGGCAGGAATGTTTGATGGATTTCTGCAAATGCCTTTTGAATTTGTCATGACTCAAAGCTTTG TCTTTGCTAATAGAAGCATAGCGATCGGTAAAATGCAATTACAGCAAAATAGAATGATACAATCCGGTGATAAAGCTACT TCGCAAATTGCTGAAATTAATACGGCTCTTGATATGGCTACTAGCGGTGATATCGGTTTCGGTGAGCATCATTTATCGCT TTTATGTTCTGCGCATAATATTAAAGCTTTGGAAGATATATTATCAATGGCAGCAGTGGAGCTTTCTAATTCAGGAATTC AACCGGTTAGAGAAAAAGTTAACATGGAACCTAGCTATTGGGGACAGTTGCCGGGAAATATGGATTATATAGTACGTAAA TCCACTATAAATACTCTTAATATGGCTAGCTTTGCCTCACTACATAATTATCCGCTCGGTAAAATTAGAGATAACCATTG GGGAGAATATGTCACAGTACTTGATACTACTTCAGGTACACCGTTTTATTTTAATTTCCATGTAAGGGATGTGGGACATA CTCTAATTATCGGTCCAACTGGTGCCGGTAAAACAGTTCTTATGAATTTCTTATGTGCGGAAGCACAAAAATTCAAACCT CGTATGTTCTTTTTTGATAAAGATCGAGGAGCAGAAATATTTATACGTGCTTTAAACGGAGTTTATACGGTAATTGATCC GGGATTAAAATGTAATTTTAATCCCTTGCAGCTTGAGGATACTAGTGAGAATAGAACATTTATTTTAGAGTGGCTTCGTG TACTTGTAACTTCTAACGGTGAAAGTTTAACTGCACAAGATAATAAAATCTTATCTCAAGCAGTAAGTGGTAATTTTAGA TTAGAGAAACAAGACAGAAGGCTTAGTAATGTTATAGCATTTCTTGGTATTGATACACCAAATAGTTTGGCAAGTAGGAT TGCAATGTGGGTTGGTAAAGGTTCACATGCTAAGATATTTGACAATGAAGTAGATGATATTGATTTACAAAAAGCAAGGG TATTCGGTTTTGATATGACTGAATTACTTAAAGATCCTGTAAGCCTTGCACCGGTATTGTTATATATTTTCCATCGCATT AATATCTCTTTAGATGGACAGAAAACTATGATAGTACTTGATGAAGCATGGGCTTTAATCGATAATCCGGTATTTGCACC TAAGATCAAAGATTGGTTAAAAGTGTTGAGAAAATTAAATACTTTTGTTATATTTGCTACGCAGAGTGTTGAAGATGCCG CAAAAAGTAGAATTAGTGATACATTAATTCAACAAACAGCTACACAGATTTTTTTACCTAATTTGAAGGCTACGGATATT TATCGTAGTGCATTTATGTTAAGTCAGCGAGAATATATTTTAATTAAAACTACCGACCCTACTACACGTTATTTTTTAAT AAAACAAGGAATAGATGCCGTAGTTGCTAAAGTTAACTTAGAAGGTATGAATAATATAATTAGTGTTTTATCAGGCAGAG TTGAGACTGTATTATTGCTCGATCAAATTAGAGAGAAATACGGCAATGATCCGGATAAGTGGTTACCTATATTTTATGAA GCAGTTAAAACATTATAG
Upstream 100 bases:
>100_bases CCGTAGGCTGACAGTATAAAATTTCTGAGATTGCCGAGTCGAGGCTTAGCCTCTTTTTGCAATGACAAAGTGAATCAAAA TCGTTAAATCAGGTGAGGTA
Downstream 100 bases:
>100_bases ATTAAATGGATACCGAGTCGTCATTGCGAGCGGTTGTAGGCTGCGTGGCAATCAAGAAAAAGTAATAAAAAAATTCTGTA AATTAGAATTTTTTACTGGA
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MKLFRTRAAKELRSKQERPTSHFIPYKCHWDSNTILTKDNSLLQVIKINGFSFETADDEDLDIKKNIRNALLKNMASGNI VMYFHTIRRRKAVIFDDTEFTYDPTVKLPNDFITYLGVEWRKKHAGARSFFNELYVSILYKPDTGGAAIVEYFLKKLRQK SNKTAWENDMKEMKENLQEMSTRVVNTFRSYGARLLGVRQTQSGNYCEILEFLSSLINCGDSPGPVALPRGTIDEYLPTH RLFFDSRTIEARSPLGKKYAGMISILEYGPNTSAGMFDGFLQMPFEFVMTQSFVFANRSIAIGKMQLQQNRMIQSGDKAT SQIAEINTALDMATSGDIGFGEHHLSLLCSAHNIKALEDILSMAAVELSNSGIQPVREKVNMEPSYWGQLPGNMDYIVRK STINTLNMASFASLHNYPLGKIRDNHWGEYVTVLDTTSGTPFYFNFHVRDVGHTLIIGPTGAGKTVLMNFLCAEAQKFKP RMFFFDKDRGAEIFIRALNGVYTVIDPGLKCNFNPLQLEDTSENRTFILEWLRVLVTSNGESLTAQDNKILSQAVSGNFR LEKQDRRLSNVIAFLGIDTPNSLASRIAMWVGKGSHAKIFDNEVDDIDLQKARVFGFDMTELLKDPVSLAPVLLYIFHRI NISLDGQKTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDAAKSRISDTLIQQTATQIFLPNLKATDI YRSAFMLSQREYILIKTTDPTTRYFLIKQGIDAVVAKVNLEGMNNIISVLSGRVETVLLLDQIREKYGNDPDKWLPIFYE AVKTL
Sequences:
>Translated_805_residues MKLFRTRAAKELRSKQERPTSHFIPYKCHWDSNTILTKDNSLLQVIKINGFSFETADDEDLDIKKNIRNALLKNMASGNI VMYFHTIRRRKAVIFDDTEFTYDPTVKLPNDFITYLGVEWRKKHAGARSFFNELYVSILYKPDTGGAAIVEYFLKKLRQK SNKTAWENDMKEMKENLQEMSTRVVNTFRSYGARLLGVRQTQSGNYCEILEFLSSLINCGDSPGPVALPRGTIDEYLPTH RLFFDSRTIEARSPLGKKYAGMISILEYGPNTSAGMFDGFLQMPFEFVMTQSFVFANRSIAIGKMQLQQNRMIQSGDKAT SQIAEINTALDMATSGDIGFGEHHLSLLCSAHNIKALEDILSMAAVELSNSGIQPVREKVNMEPSYWGQLPGNMDYIVRK STINTLNMASFASLHNYPLGKIRDNHWGEYVTVLDTTSGTPFYFNFHVRDVGHTLIIGPTGAGKTVLMNFLCAEAQKFKP RMFFFDKDRGAEIFIRALNGVYTVIDPGLKCNFNPLQLEDTSENRTFILEWLRVLVTSNGESLTAQDNKILSQAVSGNFR LEKQDRRLSNVIAFLGIDTPNSLASRIAMWVGKGSHAKIFDNEVDDIDLQKARVFGFDMTELLKDPVSLAPVLLYIFHRI NISLDGQKTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDAAKSRISDTLIQQTATQIFLPNLKATDI YRSAFMLSQREYILIKTTDPTTRYFLIKQGIDAVVAKVNLEGMNNIISVLSGRVETVLLLDQIREKYGNDPDKWLPIFYE AVKTL >Mature_805_residues MKLFRTRAAKELRSKQERPTSHFIPYKCHWDSNTILTKDNSLLQVIKINGFSFETADDEDLDIKKNIRNALLKNMASGNI VMYFHTIRRRKAVIFDDTEFTYDPTVKLPNDFITYLGVEWRKKHAGARSFFNELYVSILYKPDTGGAAIVEYFLKKLRQK SNKTAWENDMKEMKENLQEMSTRVVNTFRSYGARLLGVRQTQSGNYCEILEFLSSLINCGDSPGPVALPRGTIDEYLPTH RLFFDSRTIEARSPLGKKYAGMISILEYGPNTSAGMFDGFLQMPFEFVMTQSFVFANRSIAIGKMQLQQNRMIQSGDKAT SQIAEINTALDMATSGDIGFGEHHLSLLCSAHNIKALEDILSMAAVELSNSGIQPVREKVNMEPSYWGQLPGNMDYIVRK STINTLNMASFASLHNYPLGKIRDNHWGEYVTVLDTTSGTPFYFNFHVRDVGHTLIIGPTGAGKTVLMNFLCAEAQKFKP RMFFFDKDRGAEIFIRALNGVYTVIDPGLKCNFNPLQLEDTSENRTFILEWLRVLVTSNGESLTAQDNKILSQAVSGNFR LEKQDRRLSNVIAFLGIDTPNSLASRIAMWVGKGSHAKIFDNEVDDIDLQKARVFGFDMTELLKDPVSLAPVLLYIFHRI NISLDGQKTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDAAKSRISDTLIQQTATQIFLPNLKATDI YRSAFMLSQREYILIKTTDPTTRYFLIKQGIDAVVAKVNLEGMNNIISVLSGRVETVLLLDQIREKYGNDPDKWLPIFYE AVKTL
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 91302; Mature: 91302
Theoretical pI: Translated: 8.63; Mature: 8.63
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLFRTRAAKELRSKQERPTSHFIPYKCHWDSNTILTKDNSLLQVIKINGFSFETADDED CCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCEEEEEEECCEEECCCCCCC LDIKKNIRNALLKNMASGNIVMYFHTIRRRKAVIFDDTEFTYDPTVKLPNDFITYLGVEW CHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCEEEEECCCCEECCCCCCCCHHHHHCCCHH RKKHAGARSFFNELYVSILYKPDTGGAAIVEYFLKKLRQKSNKTAWENDMKEMKENLQEM HHHHCHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH STRVVNTFRSYGARLLGVRQTQSGNYCEILEFLSSLINCGDSPGPVALPRGTIDEYLPTH HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCCH RLFFDSRTIEARSPLGKKYAGMISILEYGPNTSAGMFDGFLQMPFEFVMTQSFVFANRSI HEEECCCCCCCCCCCCHHHHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHHHHHEECCCE AIGKMQLQQNRMIQSGDKATSQIAEINTALDMATSGDIGFGEHHLSLLCSAHNIKALEDI EEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHH LSMAAVELSNSGIQPVREKVNMEPSYWGQLPGNMDYIVRKSTINTLNMASFASLHNYPLG HHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC KIRDNHWGEYVTVLDTTSGTPFYFNFHVRDVGHTLIIGPTGAGKTVLMNFLCAEAQKFKP CCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCC RMFFFDKDRGAEIFIRALNGVYTVIDPGLKCNFNPLQLEDTSENRTFILEWLRVLVTSNG EEEEEECCCCCEEEEEHHCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC ESLTAQDNKILSQAVSGNFRLEKQDRRLSNVIAFLGIDTPNSLASRIAMWVGKGSHAKIF CEEECCHHHHHHHHHCCCEEEEHHHHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCEEC DNEVDDIDLQKARVFGFDMTELLKDPVSLAPVLLYIFHRINISLDGQKTMIVLDEAWALI CCCCCCCCCCHHHEECCCHHHHHCCCHHHHHHHHHHHHHHEEEECCCEEEEEEECCHHHH DNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDAAKSRISDTLIQQTATQIFLPNLKATDI CCCCCCHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH YRSAFMLSQREYILIKTTDPTTRYFLIKQGIDAVVAKVNLEGMNNIISVLSGRVETVLLL HHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHEEHEEEHHHHHHHHHHHCCCHHHHHHH DQIREKYGNDPDKWLPIFYEAVKTL HHHHHHHCCCCCHHHHHHHHHHHCC >Mature Secondary Structure MKLFRTRAAKELRSKQERPTSHFIPYKCHWDSNTILTKDNSLLQVIKINGFSFETADDED CCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCEEEEEEECCEEECCCCCCC LDIKKNIRNALLKNMASGNIVMYFHTIRRRKAVIFDDTEFTYDPTVKLPNDFITYLGVEW CHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCEEEEECCCCEECCCCCCCCHHHHHCCCHH RKKHAGARSFFNELYVSILYKPDTGGAAIVEYFLKKLRQKSNKTAWENDMKEMKENLQEM HHHHCHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH STRVVNTFRSYGARLLGVRQTQSGNYCEILEFLSSLINCGDSPGPVALPRGTIDEYLPTH HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCCH RLFFDSRTIEARSPLGKKYAGMISILEYGPNTSAGMFDGFLQMPFEFVMTQSFVFANRSI HEEECCCCCCCCCCCCHHHHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHHHHHEECCCE AIGKMQLQQNRMIQSGDKATSQIAEINTALDMATSGDIGFGEHHLSLLCSAHNIKALEDI EEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHH LSMAAVELSNSGIQPVREKVNMEPSYWGQLPGNMDYIVRKSTINTLNMASFASLHNYPLG HHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC KIRDNHWGEYVTVLDTTSGTPFYFNFHVRDVGHTLIIGPTGAGKTVLMNFLCAEAQKFKP CCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCC RMFFFDKDRGAEIFIRALNGVYTVIDPGLKCNFNPLQLEDTSENRTFILEWLRVLVTSNG EEEEEECCCCCEEEEEHHCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC ESLTAQDNKILSQAVSGNFRLEKQDRRLSNVIAFLGIDTPNSLASRIAMWVGKGSHAKIF CEEECCHHHHHHHHHCCCEEEEHHHHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCEEC DNEVDDIDLQKARVFGFDMTELLKDPVSLAPVLLYIFHRINISLDGQKTMIVLDEAWALI CCCCCCCCCCHHHEECCCHHHHHCCCHHHHHHHHHHHHHHEEEECCCEEEEEEECCHHHH DNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDAAKSRISDTLIQQTATQIFLPNLKATDI CCCCCCHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH YRSAFMLSQREYILIKTTDPTTRYFLIKQGIDAVVAKVNLEGMNNIISVLSGRVETVLLL HHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHEEHEEEHHHHHHHHHHHCCCHHHHHHH DQIREKYGNDPDKWLPIFYEAVKTL HHHHHHHCCCCCHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]