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The map label for this gene is parC [H]

Identifier: 157825225

GI number: 157825225

Start: 85586

End: 87799

Strand: Direct

Name: parC [H]

Synonym: A1C_00520

Alternate gene names: 157825225

Gene position: 85586-87799 (Clockwise)

Preceding gene: 157825224

Following gene: 157825229

Centisome position: 6.95

GC content: 36.5

Gene sequence:

>2214_bases
ATGAAAGAAGCTAAAATAGAAAATATTGACTTTGGTAATGCATTATCGGAGCGTTATCTTGCTTACGCGTTGTCAACGAT
TATGTCACGTTCGCTTCCTGACGTACGCGATGGACTTAAGCCTGTACATCGTAGGTTATTATACGCAATGCTACAGCTAA
AGCTTGAGCCGAATTCCGGCTATAAGAAATGTGCAAGGGTGGTTGGTGACGTAATAGGTAAATACCACCCGCACGGTGAT
GTGGCAGTGTATGATACTTTGGTACGCCTTGCTCAGCATTTTTCGTTACGTTATCCTTTGATTGACGGGCAGGGTAATTT
CGGCTCTATCGACGGTGATAATGCAGCAGCTATGCGTTATACCGAATCACGTATGACGGAAATATGTACTTTATTAATGG
TAGACATTGATAAAGATACGGTAGATTTTCGCCCTACTTATGATGATTCCGATTTAGAACCGATAATAATGCCGGCAAGT
TTTCCGAATTTACTAGCTAACGGTTCTGAAGGGATAGCAGTCGGTATGGCAACCAATATACCGCCGCACAATTTACATGA
GCTTTGTGATGCTCTAATACATTTAATCGACCACCCGAACGCTGAAATTAATGATATAATGAACTTTATCAAAGGTCCTG
ATTTTCCAACAGGCGGTATAATTATTGATAAAGCTGAAGTTATTAATGCTGCATATAATACCGGACGCGGTAGTTTTAGA
GTGAGAAGTAGATGGGAAAAAGAGGCGTTAAGTTACGGTACATATCAGATAGTCGTAACCGAAATACCTTATCAGGTTCA
GAAATCAAAACTTATAGAACAAGTAGCCATATTACTAAAGGATAAAAAAATCCCGCTTGTTAGCAATATTAGAGATGAAT
CAACCGACATTATAAGGTTGGTTATAGAGCCAAGAGACCGGAGTTGTGATCCGCAGATAGTTATGGAGTCTTTATTTAAG
CTAACTAATTTAGAAAGCCGCATTCAGCTAAATATGAATGTGATTGGCAGTAATAACGTGCCTAGAGTAATGAATATTTT
AGAGGTTTTACAAGAGTTTTTAGCTCATAGACAAAATATTGTTACTCGCAGGTCAACTTATCTTGTGAATAAAATCAAGC
ATCGTTTAGAAATTCTAGCAGGGCTTAGAATAGCTTATCTAAATCTTGATGAGATAATTAAAATTATTCGTGAAGAGGAT
GAGCCGAAAGCGATAATGATGGAGCGGTTTAAACTAACCGAAATACAGGTAGAAGCAATATTAAATACTCGTCTTCGTTC
GCTACGCAAGCTTGAAGAGCATGAAATTATTAATGAGCATAGTAATTTGCAGAAGCAGCAAGCTATATTAGAAGAGATTT
TAAATAATCCTAAAGAGCTATGGAAAATAGTTAAAAAAGAAATCAAAGCAGTACAAATGCAATTTGGATTAAATACCGTA
ATAGGAGATAGACGTACAAGCTTTGAAGAAGTAACGCTTACGAATCAAGTAGTTGATATAACAGCGTTTGTTACTAAAGA
GCCGATTACTATTATCTGCTCAAAAATGGGGTGGGTGCGTTCACTAAAAGGTCATAACACCGATTTATCGAATATTAAAT
ACAAAGAAGGTGATGCAGAGAAGTTTATTTTAGAAGCTTATACAACTGATAAAATATTAATAGTTAGTTCGGAAGGTAGG
TTTTTTACTTTGCTTGCCGATAATATTCCCAAAGGTAAAGGAACCGGCGAATCTATAAAGCTGCTTGTGGATATAGGTAA
TAACGATATTACTAATATTTTAGTCCATAAACCTGATCAGCTTTTATTACTCGCAAGTAGTGTAGGGAAGGGGTTTTTAG
TTAATTCAAACGAAGTAATAGCTCAAACAAAAACAGGGAAGCAGGTTATGAATGTACCGGATGGTCATGCATGTATAGCT
TGTTTACATGTAGCGGGTGATGCCGTTGCCTGTATCGGTGAGAGCCGTAAATTATTGGTATTTAATGTAGATGAAATACC
GGAAATGAAAAAGGGGCAAGGCGTAACGCTGCAAAAATTTAAGAATGCAAAGTTACTTGATATTAAAATATTTAATAAAG
AAGATGGCTTATGTTGGAACAACAATGGAAAAGTAAAACTTGAGAAAAATATCATTGCATTTTTAGGACAAAGAGGTAGT
ACTGGTAAATTACCGCCTATGGGTTTTCCCAAAAATAATAGATTTTCATCATAA

Upstream 100 bases:

>100_bases
ATTAAACAAATTCTGTAAATCAGAATTTTTTACTGGATTGCTTCGTCGAATTACTACGTAATTCTTCTCGCAATGATGAT
AAATAAAAATTAAATAACTT

Downstream 100 bases:

>100_bases
TTATAATATAGATTGAGTGTATACAAAAAAATAGCATATTTTATATTGTGTGATACAAGCGACTTATCTATAAATTCGCT
TGTATCGTTCTATTATTAAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLKLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICTLLMVDIDKDTVDFRPTYDDSDLEPIIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLIDHPNAEINDIMNFIKGPDFPTGGIIIDKAEVINAAYNTGRGSFR
VRSRWEKEALSYGTYQIVVTEIPYQVQKSKLIEQVAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRSCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEVLQEFLAHRQNIVTRRSTYLVNKIKHRLEILAGLRIAYLNLDEIIKIIREED
EPKAIMMERFKLTEIQVEAILNTRLRSLRKLEEHEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKAVQMQFGLNTV
IGDRRTSFEEVTLTNQVVDITAFVTKEPITIICSKMGWVRSLKGHNTDLSNIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNIPKGKGTGESIKLLVDIGNNDITNILVHKPDQLLLLASSVGKGFLVNSNEVIAQTKTGKQVMNVPDGHACIA
CLHVAGDAVACIGESRKLLVFNVDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLCWNNNGKVKLEKNIIAFLGQRGS
TGKLPPMGFPKNNRFSS

Sequences:

>Translated_737_residues
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLKLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICTLLMVDIDKDTVDFRPTYDDSDLEPIIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLIDHPNAEINDIMNFIKGPDFPTGGIIIDKAEVINAAYNTGRGSFR
VRSRWEKEALSYGTYQIVVTEIPYQVQKSKLIEQVAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRSCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEVLQEFLAHRQNIVTRRSTYLVNKIKHRLEILAGLRIAYLNLDEIIKIIREED
EPKAIMMERFKLTEIQVEAILNTRLRSLRKLEEHEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKAVQMQFGLNTV
IGDRRTSFEEVTLTNQVVDITAFVTKEPITIICSKMGWVRSLKGHNTDLSNIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNIPKGKGTGESIKLLVDIGNNDITNILVHKPDQLLLLASSVGKGFLVNSNEVIAQTKTGKQVMNVPDGHACIA
CLHVAGDAVACIGESRKLLVFNVDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLCWNNNGKVKLEKNIIAFLGQRGS
TGKLPPMGFPKNNRFSS
>Mature_737_residues
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLKLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICTLLMVDIDKDTVDFRPTYDDSDLEPIIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLIDHPNAEINDIMNFIKGPDFPTGGIIIDKAEVINAAYNTGRGSFR
VRSRWEKEALSYGTYQIVVTEIPYQVQKSKLIEQVAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRSCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEVLQEFLAHRQNIVTRRSTYLVNKIKHRLEILAGLRIAYLNLDEIIKIIREED
EPKAIMMERFKLTEIQVEAILNTRLRSLRKLEEHEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKAVQMQFGLNTV
IGDRRTSFEEVTLTNQVVDITAFVTKEPITIICSKMGWVRSLKGHNTDLSNIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNIPKGKGTGESIKLLVDIGNNDITNILVHKPDQLLLLASSVGKGFLVNSNEVIAQTKTGKQVMNVPDGHACIA
CLHVAGDAVACIGESRKLLVFNVDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLCWNNNGKVKLEKNIIAFLGQRGS
TGKLPPMGFPKNNRFSS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=466, Percent_Identity=23.3905579399142, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI19913406, Length=359, Percent_Identity=24.5125348189415, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1789396, Length=687, Percent_Identity=40.9024745269287, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1788562, Length=615, Percent_Identity=41.6260162601626, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI212645845, Length=346, Percent_Identity=25.1445086705202, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=178, Percent_Identity=30.8988764044944, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=364, Percent_Identity=26.0989010989011, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136538, Length=366, Percent_Identity=25.1366120218579, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82931; Mature: 82931

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLKLEPNSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCC
YKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECEEECCCCCCCCCCCCCCCEEEE
TESRMTEICTLLMVDIDKDTVDFRPTYDDSDLEPIIMPASFPNLLANGSEGIAVGMATNI
HHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEEECCC
PPHNLHELCDALIHLIDHPNAEINDIMNFIKGPDFPTGGIIIDKAEVINAAYNTGRGSFR
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCEE
VRSRWEKEALSYGTYQIVVTEIPYQVQKSKLIEQVAILLKDKKIPLVSNIRDESTDIIRL
EHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEE
VIEPRDRSCDPQIVMESLFKLTNLESRIQLNMNVIGSNNVPRVMNILEVLQEFLAHRQNI
EECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VTRRSTYLVNKIKHRLEILAGLRIAYLNLDEIIKIIREEDEPKAIMMERFKLTEIQVEAI
HHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LNTRLRSLRKLEEHEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKAVQMQFGLNTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHH
IGDRRTSFEEVTLTNQVVDITAFVTKEPITIICSKMGWVRSLKGHNTDLSNIKYKEGDAE
HCCCCCCHHHEEECHHEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCC
KFILEAYTTDKILIVSSEGRFFTLLADNIPKGKGTGESIKLLVDIGNNDITNILVHKPDQ
EEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCC
LLLLASSVGKGFLVNSNEVIAQTKTGKQVMNVPDGHACIACLHVAGDAVACIGESRKLLV
EEEEEECCCCCEEECCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCCCEEEE
FNVDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLCWNNNGKVKLEKNIIAFLGQRGS
EECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEEECCCCCEEECCCHHHHHCCCCC
TGKLPPMGFPKNNRFSS
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLKLEPNSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCC
YKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECEEECCCCCCCCCCCCCCCEEEE
TESRMTEICTLLMVDIDKDTVDFRPTYDDSDLEPIIMPASFPNLLANGSEGIAVGMATNI
HHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEEECCC
PPHNLHELCDALIHLIDHPNAEINDIMNFIKGPDFPTGGIIIDKAEVINAAYNTGRGSFR
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCEE
VRSRWEKEALSYGTYQIVVTEIPYQVQKSKLIEQVAILLKDKKIPLVSNIRDESTDIIRL
EHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEE
VIEPRDRSCDPQIVMESLFKLTNLESRIQLNMNVIGSNNVPRVMNILEVLQEFLAHRQNI
EECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VTRRSTYLVNKIKHRLEILAGLRIAYLNLDEIIKIIREEDEPKAIMMERFKLTEIQVEAI
HHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LNTRLRSLRKLEEHEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKAVQMQFGLNTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHH
IGDRRTSFEEVTLTNQVVDITAFVTKEPITIICSKMGWVRSLKGHNTDLSNIKYKEGDAE
HCCCCCCHHHEEECHHEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCC
KFILEAYTTDKILIVSSEGRFFTLLADNIPKGKGTGESIKLLVDIGNNDITNILVHKPDQ
EEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCC
LLLLASSVGKGFLVNSNEVIAQTKTGKQVMNVPDGHACIACLHVAGDAVACIGESRKLLV
EEEEEECCCCCEEECCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCCCEEEE
FNVDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLCWNNNGKVKLEKNIIAFLGQRGS
EECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEEECCCCCEEECCCHHHHHCCCCC
TGKLPPMGFPKNNRFSS
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]