Click here to switch to the map view.

The map label for this gene is kdsA

Identifier: 157825218

GI number: 157825218

Start: 78798

End: 79622

Strand: Direct

Name: kdsA

Synonym: A1C_00485

Alternate gene names: 157825218

Gene position: 78798-79622 (Clockwise)

Preceding gene: 157825217

Following gene: 157825219

Centisome position: 6.4

GC content: 34.42

Gene sequence:

>825_bases
ATGCAAAAAATAGTAAAACTTAACAATATCAAAATAGGAAATGATTTACCGTTTGTTCTCATTGCAGGGCCTTGTCAGAT
TGAAGGAAAAGATCATGCATTGTTTATGGCAGAAAAACTTGTTAAATTAACTAGCAAGCTGGATATTGCATTTATTTATA
AATCTTCTTTTGATAAAGCTAATAGAACTTCCGTAAATGGAATTAGAGGAGTTGGTATTGAGAAAGGTTTAGAAATTTTA
TCAAAAGTAAAATCTGAATTCGATTGCCCTATTGTTACTGATATTCATTCAGAGAGTCAATGTACTGAAACAGCCGAAGT
AGCAGATATTTTACAAATTCCGGCATTTCTATGTAGACAAACTGACTTGCTACAAGCTGCAGCAAAAACAGGTAAAATAG
TAAAAGTCAAAAAAGGGCAGTTTCTAGCTCCGTGGGATATGAAAAATGTACAAACAAAACTACAAGCTTTTGGAGTAAAG
GATATATTATTTACAGAGCGGGGAGCATGTTTTGGTTATAATAATTTGGTATCTGATATGCGTAGTCTTGCAATAATGGC
AGAATTAAATGTACCTATAGTTTTTGATGCAACACATTCCGTTCAGCAGCCTGGAGGACTAGGAGGTAGTACCGGAGGGG
ACAGAAAATATGTAGAGCTACTTGCAAAGGCAGCAATTGCTGTAGGTATCGCCGGTATGTATATGGAAGTACATCAAGAT
CCCGATAACGCTCCAAGTGATGGTCCATGTATGATGAAGTTAGATAATCTAGAGTCCATACTTATCAAACTAAAAAAATA
TGATAAAATTACAAAAGAAAAATAA

Upstream 100 bases:

>100_bases
ACACTGATAATTAACAATGACTTAATAAAAAATGAATCAGTACCTGATATAACAGAGCAACACTAATCCATGCATCACTC
AATAATTAAATCTAAGAATT

Downstream 100 bases:

>100_bases
CCTCAAATTTTATTTTTCAAAAAACATATACAATATCCTCTATTAATTCAATTTAAAAATGGAAGTGATAATTTTTTGCA
AAATAAAAAATAGAATTTTC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MQKIVKLNNIKIGNDLPFVLIAGPCQIEGKDHALFMAEKLVKLTSKLDIAFIYKSSFDKANRTSVNGIRGVGIEKGLEIL
SKVKSEFDCPIVTDIHSESQCTETAEVADILQIPAFLCRQTDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLQAFGVK
DILFTERGACFGYNNLVSDMRSLAIMAELNVPIVFDATHSVQQPGGLGGSTGGDRKYVELLAKAAIAVGIAGMYMEVHQD
PDNAPSDGPCMMKLDNLESILIKLKKYDKITKEK

Sequences:

>Translated_274_residues
MQKIVKLNNIKIGNDLPFVLIAGPCQIEGKDHALFMAEKLVKLTSKLDIAFIYKSSFDKANRTSVNGIRGVGIEKGLEIL
SKVKSEFDCPIVTDIHSESQCTETAEVADILQIPAFLCRQTDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLQAFGVK
DILFTERGACFGYNNLVSDMRSLAIMAELNVPIVFDATHSVQQPGGLGGSTGGDRKYVELLAKAAIAVGIAGMYMEVHQD
PDNAPSDGPCMMKLDNLESILIKLKKYDKITKEK
>Mature_274_residues
MQKIVKLNNIKIGNDLPFVLIAGPCQIEGKDHALFMAEKLVKLTSKLDIAFIYKSSFDKANRTSVNGIRGVGIEKGLEIL
SKVKSEFDCPIVTDIHSESQCTETAEVADILQIPAFLCRQTDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLQAFGVK
DILFTERGACFGYNNLVSDMRSLAIMAELNVPIVFDATHSVQQPGGLGGSTGGDRKYVELLAKAAIAVGIAGMYMEVHQD
PDNAPSDGPCMMKLDNLESILIKLKKYDKITKEK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=273, Percent_Identity=43.956043956044, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_RICAH (A8GM05)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001492938.1
- ProteinModelPortal:   A8GM05
- SMR:   A8GM05
- STRING:   A8GM05
- GeneID:   5645371
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_00485
- NMPDR:   fig|293614.3.peg.85
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   RSLPIMA
- ProtClustDB:   PRK05198
- BioCyc:   RAKA293614:A1C_00485-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 29978; Mature: 29978

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIVKLNNIKIGNDLPFVLIAGPCQIEGKDHALFMAEKLVKLTSKLDIAFIYKSSFDKA
CCCEEEECCEEECCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCC
NRTSVNGIRGVGIEKGLEILSKVKSEFDCPIVTDIHSESQCTETAEVADILQIPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
TDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLQAFGVKDILFTERGACFGYNNLVSDM
HHHHHHHHHCCCEEEEECCCEECCCCHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHH
RSLAIMAELNVPIVFDATHSVQQPGGLGGSTGGDRKYVELLAKAAIAVGIAGMYMEVHQD
HHHEEEEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECC
PDNAPSDGPCMMKLDNLESILIKLKKYDKITKEK
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQKIVKLNNIKIGNDLPFVLIAGPCQIEGKDHALFMAEKLVKLTSKLDIAFIYKSSFDKA
CCCEEEECCEEECCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCC
NRTSVNGIRGVGIEKGLEILSKVKSEFDCPIVTDIHSESQCTETAEVADILQIPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
TDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLQAFGVKDILFTERGACFGYNNLVSDM
HHHHHHHHHCCCEEEEECCCEECCCCHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHH
RSLAIMAELNVPIVFDATHSVQQPGGLGGSTGGDRKYVELLAKAAIAVGIAGMYMEVHQD
HHHEEEEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECC
PDNAPSDGPCMMKLDNLESILIKLKKYDKITKEK
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA