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The map label for this gene is atpB [H]

Identifier: 157825171

GI number: 157825171

Start: 34465

End: 35193

Strand: Direct

Name: atpB [H]

Synonym: A1C_00250

Alternate gene names: 157825171

Gene position: 34465-35193 (Clockwise)

Preceding gene: 157825170

Following gene: 157825172

Centisome position: 2.8

GC content: 30.45

Gene sequence:

>729_bases
ATGACTCACAGCCCTTTAGCACAATTTGATATCAAAAAATTGATAGACATCAAAATGTTCGGTTTTGACATCAGCTTTAC
TAATTCGAGTATCTATATGTTACTTGCTAGCATCTTGGCTCTAACTTATTTTTACTTAGCTTTTTATAACCGAAAATTAG
TACCTTCTAGACTACAAGTAAGTGCTGAAATAGTTTATAATCTTGTAGCTGATATGTTAAATCAGAACATAGGAGTAAAG
GGACACAAGTTTATTCCGTTAGTTTTTAGTTTGTTCATTTTTGTTTTATTTTCTAATTTGCTTGGTATGACACCTTATAG
CTTTACTGCTACTAGTCATATTATCGTTACTTTTACCTTAGCAATTATAGTATTTTTAACGGTCACTATAGTTGGTTTCG
TAAAACACGGCTTACGTTTTTTAACTCTTTTTTTACCATACGGTACTCCTTTATGGTTAGCACCATTGATGATAGTAATT
GAACTGTTTACATATTTAGCAAAACCGGTTAGTTTATCATTGCGACTTGCTGCTAATATGATGGCGGGACATGTTTTATT
AAAAGTAATAGCCGGTTTTACCGTTTCATTAATGATTTACTTGAAATTTCTACCAATCCCTATTATAGTGATACTAATTG
GGTTTGAAATTTTTGTTGCAATACTTCAAGCTTATATTTTTACTATTTTATCTTGTATGTATCTTAATGATGCTATTAAT
TTACACTAG

Upstream 100 bases:

>100_bases
TTACGGATAAGTTTTTTAATTCTAAACCATTATTTCTTATTGTATTTACAATAATAGGAATGATTGCCGGCTTTAACATT
ATAATACAGAAAATAAGGAA

Downstream 100 bases:

>100_bases
GCCTGTCACACAACTTGCTTCTAAAGGTAATTTGTACGTCAATCCGATGCTAAAATCCTCACGTACTTTTTTGTACGCTG
CGGTTCTGTGCTTGGTATTT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTHSPLAQFDIKKLIDIKMFGFDISFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVK
GHKFIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTLAIIVFLTVTIVGFVKHGLRFLTLFLPYGTPLWLAPLMIVI
ELFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCMYLNDAIN
LH

Sequences:

>Translated_242_residues
MTHSPLAQFDIKKLIDIKMFGFDISFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVK
GHKFIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTLAIIVFLTVTIVGFVKHGLRFLTLFLPYGTPLWLAPLMIVI
ELFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCMYLNDAIN
LH
>Mature_241_residues
THSPLAQFDIKKLIDIKMFGFDISFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVKG
HKFIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTLAIIVFLTVTIVGFVKHGLRFLTLFLPYGTPLWLAPLMIVIE
LFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCMYLNDAINL
H

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=221, Percent_Identity=32.579185520362, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1790176, Length=214, Percent_Identity=28.0373831775701, Blast_Score=61, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=249, Percent_Identity=36.144578313253, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 27296; Mature: 27164

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure 
THSPLAQFDIKKLIDIKMFGFDISFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQV
CCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SAEIVYNLVADMLNQNIGVKGHKFIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AIIVFLTVTIVGFVKHGLRFLTLFLPYGTPLWLAPLMIVIELFTYLAKPVSLSLRLAANM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAGHVLLKVIAGFTVSLMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCMYLNDAIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA