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The map label for this gene is lpxA [H]

Identifier: 157825131

GI number: 157825131

Start: 6021

End: 6737

Strand: Reverse

Name: lpxA [H]

Synonym: A1C_00030

Alternate gene names: 157825131

Gene position: 6737-6021 (Counterclockwise)

Preceding gene: 157825132

Following gene: NA

Centisome position: 0.55

GC content: 36.4

Gene sequence:

>717_bases
TTGTGTGTTATAGGTCCTGAAGTTGTACTTCATGATAATATCGAGCTAAAATCCCATGTAGTGATTGAAGGGATTACCGA
AATCGGCAAAAATACCGTAATATATCCTTTTGCATCAATCGGTCAACCTCCGCAAATCTTAAAATATACTAATGAGCGAT
CAAGCACGATAATCGGCTCTAATAATACTATTAGAGAATATGTTACGGTACAAGCAGGAAGCCAAGGCGGCGGAATGATA
ACAAGAATAGAAAATAATAATTTATTCATGGTCGGTGTTCATATCGGTCATGATTGTAAAATCGGCAATAACGTAGTATT
TGCTAATTACGTAAGCCTAGCAGGTCATATTGAGGTAGGTGATTATGCAATAATCGGTGGATTATCGGCAGTTCATCAAT
ATGCTAAAATCGGCAAATATTCGATGATTGGCGGGCTATCACCGGTCGGAGCAGATGTAATACCGTTTGGGCTTGTAAGT
AGCAAACGTGCTGTGCTTGAGGGTTTAAACCTAATCGGTATGAATAGAAAAGGATTTGATAAAGCAGAGTCTTTAAGTGC
TTTAAAAGCTATCAAAGAAATCTTCTCAGGTGAAGGTAATTTTGCTGAGCGTATAAAACAAGTTGCCGAGAAATATAAAA
ATAATTCTATAGTAATGCAAATTATCGATTTTCTTAATCAAGATAGTAGTAGAGCATTTTGTCGTTTTGAGAAGTAA

Upstream 100 bases:

>100_bases
AAGATAAATCATAGGAAAAAGTAGTGGCAAATAACATCCATACTACAGCTATAATTGCAGAAGGTGCAAAGCTCGGTGAA
AACGTAAAAATCGGACCGTA

Downstream 100 bases:

>100_bases
CTTTAGATTGCTTCGTCAAAACTTACAGTTTTTCCTCTCAATGACGAAACATTTTCTCTTGTAAAGAATTTTGGCGTAAA
CGAGTTTTCAAGCTCTTAAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MCVIGPEVVLHDNIELKSHVVIEGITEIGKNTVIYPFASIGQPPQILKYTNERSSTIIGSNNTIREYVTVQAGSQGGGMI
TRIENNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIEVGDYAIIGGLSAVHQYAKIGKYSMIGGLSPVGADVIPFGLVS
SKRAVLEGLNLIGMNRKGFDKAESLSALKAIKEIFSGEGNFAERIKQVAEKYKNNSIVMQIIDFLNQDSSRAFCRFEK

Sequences:

>Translated_238_residues
MCVIGPEVVLHDNIELKSHVVIEGITEIGKNTVIYPFASIGQPPQILKYTNERSSTIIGSNNTIREYVTVQAGSQGGGMI
TRIENNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIEVGDYAIIGGLSAVHQYAKIGKYSMIGGLSPVGADVIPFGLVS
SKRAVLEGLNLIGMNRKGFDKAESLSALKAIKEIFSGEGNFAERIKQVAEKYKNNSIVMQIIDFLNQDSSRAFCRFEK
>Mature_238_residues
MCVIGPEVVLHDNIELKSHVVIEGITEIGKNTVIYPFASIGQPPQILKYTNERSSTIIGSNNTIREYVTVQAGSQGGGMI
TRIENNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIEVGDYAIIGGLSAVHQYAKIGKYSMIGGLSPVGADVIPFGLVS
SKRAVLEGLNLIGMNRKGFDKAESLSALKAIKEIFSGEGNFAERIKQVAEKYKNNSIVMQIIDFLNQDSSRAFCRFEK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=236, Percent_Identity=40.6779661016949, Blast_Score=181, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 25836; Mature: 25836

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVIGPEVVLHDNIELKSHVVIEGITEIGKNTVIYPFASIGQPPQILKYTNERSSTIIGS
CEEECCEEEEECCCCCCHHEEEEEHHHHCCCCEEEEHHHCCCCHHHHEECCCCCCEEECC
NNTIREYVTVQAGSQGGGMITRIENNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIEVG
CCCEEEEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCEECCCEEEEEEEEEEEEEEEC
DYAIIGGLSAVHQYAKIGKYSMIGGLSPVGADVIPFGLVSSKRAVLEGLNLIGMNRKGFD
CEEEEHHHHHHHHHHHCCCCHHHCCCCCCCCCHHCCCHHCCHHHHHCCCCEEECCCCCCC
KAESLSALKAIKEIFSGEGNFAERIKQVAEKYKNNSIVMQIIDFLNQDSSRAFCRFEK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MCVIGPEVVLHDNIELKSHVVIEGITEIGKNTVIYPFASIGQPPQILKYTNERSSTIIGS
CEEECCEEEEECCCCCCHHEEEEEHHHHCCCCEEEEHHHCCCCHHHHEECCCCCCEEECC
NNTIREYVTVQAGSQGGGMITRIENNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIEVG
CCCEEEEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCEECCCEEEEEEEEEEEEEEEC
DYAIIGGLSAVHQYAKIGKYSMIGGLSPVGADVIPFGLVSSKRAVLEGLNLIGMNRKGFD
CEEEEHHHHHHHHHHHCCCCHHHCCCCCCCCCHHCCCHHCCHHHHHCCCCEEECCCCCCC
KAESLSALKAIKEIFSGEGNFAERIKQVAEKYKNNSIVMQIIDFLNQDSSRAFCRFEK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA