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The map label for this gene is gmk [H]

Identifier: 157373098

GI number: 157373098

Start: 5390448

End: 5391071

Strand: Direct

Name: gmk [H]

Synonym: Spro_4867

Alternate gene names: 157373098

Gene position: 5390448-5391071 (Clockwise)

Preceding gene: 157373097

Following gene: 157373099

Centisome position: 98.93

GC content: 54.01

Gene sequence:

>624_bases
ATGGCTCAAGGCACGCTTTATATTGTCTCTGCCCCCAGTGGCGCAGGGAAATCAAGTCTGATTCAGGCTTTGTTAAAGAC
GCAACCGCTGTACGACACGCAGGTTTCGGTTTCGCACACCACGCGCGACAGCCGCCCGGGTGAACAGCACGGCGATCATT
ATTTCTTCGTCTCAAAAGATGAATTCTGCCAAATGATTGAGCAGGATGCGTTTCTTGAGCACGCGGAAGTGTTCGGCAAC
TATTACGGGACCTCACGTGCCGCTATTGAGCAAGTGTTGTCGACCGGCGTAGACGTTTTCCTGGATATCGACTGGCAGGG
CGCACAGCAAATTCGCGCCAAAATGCCACAGGCGCGCAGCATCTTTATTTTGCCGCCGTCGAAGGACGAACTTGGCCGTC
GCCTGCGTGGCCGCGGGCAAGACTCGGATGAGGTGATCGCCAAACGCATGGCTCAGGCCGTGGCCGAAATGGCACACTAC
GCGGAGTATGATTATTTAATCGTGAACGATGATTTCGATCTGGCCCTGTCCGATCTGAAAACCATTATTCGCGCCGAACG
CCTGCGTTTAGGCCGCCAATTACTGCGGCATGACGCTTTAATCAGCAAACTATTGGCAGACTGA

Upstream 100 bases:

>100_bases
CGAGCTAACGCTGCATCCGGCTCGTTAGCCGTGTATACTGTGCGGAGAAAATACACATCCGCTGTTATTGGCATATCAAC
CGCTATCAACGAACATCATC

Downstream 100 bases:

>100_bases
AGACAGTTTCAGTATTATGCCCAGTCTTTTCGTCACCTGTGGAGTAGCACAAATATGGCACGCGTAACTGTTCAAGACGC
TGTAGAGAAAATTGGTAACC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRDSRPGEQHGDHYFFVSKDEFCQMIEQDAFLEHAEVFGN
YYGTSRAAIEQVLSTGVDVFLDIDWQGAQQIRAKMPQARSIFILPPSKDELGRRLRGRGQDSDEVIAKRMAQAVAEMAHY
AEYDYLIVNDDFDLALSDLKTIIRAERLRLGRQLLRHDALISKLLAD

Sequences:

>Translated_207_residues
MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRDSRPGEQHGDHYFFVSKDEFCQMIEQDAFLEHAEVFGN
YYGTSRAAIEQVLSTGVDVFLDIDWQGAQQIRAKMPQARSIFILPPSKDELGRRLRGRGQDSDEVIAKRMAQAVAEMAHY
AEYDYLIVNDDFDLALSDLKTIIRAERLRLGRQLLRHDALISKLLAD
>Mature_206_residues
AQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRDSRPGEQHGDHYFFVSKDEFCQMIEQDAFLEHAEVFGNY
YGTSRAAIEQVLSTGVDVFLDIDWQGAQQIRAKMPQARSIFILPPSKDELGRRLRGRGQDSDEVIAKRMAQAVAEMAHYA
EYDYLIVNDDFDLALSDLKTIIRAERLRLGRQLLRHDALISKLLAD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=39.8907103825137, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=39.8907103825137, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=39.8907103825137, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI38570142, Length=181, Percent_Identity=32.5966850828729, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI21361598, Length=202, Percent_Identity=30.1980198019802, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI21536464, Length=179, Percent_Identity=29.608938547486, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=88.4057971014493, Blast_Score=376, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=37.0165745856354, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=37.0165745856354, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=46.7741935483871, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=38.4615384615385, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077626, Length=174, Percent_Identity=29.3103448275862, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330162, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330166, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330164, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23263; Mature: 23131

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRDSRPGEQHGDHYFFVSKD
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECHH
EFCQMIEQDAFLEHAEVFGNYYGTSRAAIEQVLSTGVDVFLDIDWQGAQQIRAKMPQARS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCE
IFILPPSKDELGRRLRGRGQDSDEVIAKRMAQAVAEMAHYAEYDYLIVNDDFDLALSDLK
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHH
TIIRAERLRLGRQLLRHDALISKLLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRDSRPGEQHGDHYFFVSKD
CCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECHH
EFCQMIEQDAFLEHAEVFGNYYGTSRAAIEQVLSTGVDVFLDIDWQGAQQIRAKMPQARS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCE
IFILPPSKDELGRRLRGRGQDSDEVIAKRMAQAVAEMAHYAEYDYLIVNDDFDLALSDLK
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHH
TIIRAERLRLGRQLLRHDALISKLLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA