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The map label for this gene is coaBC [H]

Identifier: 157373075

GI number: 157373075

Start: 5361892

End: 5363109

Strand: Direct

Name: coaBC [H]

Synonym: Spro_4843

Alternate gene names: 157373075

Gene position: 5361892-5363109 (Clockwise)

Preceding gene: 157373070

Following gene: 157373076

Centisome position: 98.4

GC content: 57.55

Gene sequence:

>1218_bases
ATGATGACGGGACTTTCCGGCAAACATATTGTGCTTGGCATCAGTGGCGGCATCGCCGCATACAAATGCCCAGAACTGGT
ACGCCGCCTGCGTGACAGAGGCGCCGAAGTGCGTGTGATAATGACCAGCGCGGCGAAAGCCTTTATCACGCCGCTGACGC
TGCAGGCCGTTTCCGGCCATCCGGTCTCAGACGATCTGCTGGATCCCGCCGCCGAAGCGGCCATGGGCCATATCGAGCTC
GGTAAATGGGCAGATCTGGTGATCCTGGCTCCGGCCACCGCCGATCTGCTGGCGCGCGTCGCCGCCGGTATGGCCAACGA
TCTACTGACCACGGTTTGCCTGGCCACCGCGGCACCCATTGCCGCTGCCCCCGCCATGAACCAGCAGATGTATCGTGCCG
TCGCCACCCAAGCCAACCTGCAAACTCTGCAGGCGCGCGGCATGCTGCTGTGGGGGCCAGACAGCGGCAGCCAGGCCTGC
GGTGACGTCGGCCCAGGTCGCATGCTCGATCCGCTGGAAATTGTCGAACTGGCGAACAGCCATTTCTCTGCACCACAAGA
TCTGCAACATTTAAAGATTATGCTCACCGCCGGCCCGACGCGCGAAGCCTTGGATCCGGTACGTTTCATCAGCAATCACA
GCTCCGGCAAGATGGGTTTTGCCATCGCCCGCGCCGCCGCTGCCAGGGGTGCACAGGTCACGTTGATAGCCGGGCCGGTC
AATCTGCCAACCCCTCCCTGGGTCACCCGGGTTGACGTCGTCAGCGCGTTGGAAATGGAGCAGGCGGTACAGCAGCGCGC
CGCAGCGCAAGATATTTTTATTTCCTGCGCCGCAGTAGCCGATTACCGTGCGGAACAGATTTCCGATGAAAAAATAAAAA
AACAGGGTGATGAAATCATCCTCAAAATGGTAAAAAACCCCGACATCGTTGCCGGCGTTGCCGCAATGACGAAAAAGCGC
CCATTTGTCGTGGGGTTTGCCGCCGAAACCCAGAATGTGGAAGAATACGCGCGACAAAAACTGGCGCGTAAGAAACTGGA
TTTAATTTGCGCTAATGATGTATCGCTTGCAGAGCATGGGTTTAACAGTGACACCAATGCCTTGCACCTTTTTTGGCAGG
ATGGAGAAAAGCGCCTGGCGCTGAGCGACAAGGCACTCCTTGGCCAACGTTTAATAGACGAGATAGTCAGCCGTTATGAT
GAAAAAAATCGACGTTAA

Upstream 100 bases:

>100_bases
GCGCAAAGCACAATGTAACGCACTGCAGACACAGCGGAATCGCTCACCTGTCTGGCGGTTATGCTAAAATGGCACATCTT
TCGGATTCAATCGGACAATC

Downstream 100 bases:

>100_bases
AATCCTGGACCCGCGTATTGGCAAGGATTTCCCATTACCGACCTACGCCACCCCTGGCTCTGCAGGCCTGGATCTGCGCG
CCTGCCTGGACAGCGCCGTT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMTGLSGKHIVLGISGGIAAYKCPELVRRLRDRGAEVRVIMTSAAKAFITPLTLQAVSGHPVSDDLLDPAAEAAMGHIEL
GKWADLVILAPATADLLARVAAGMANDLLTTVCLATAAPIAAAPAMNQQMYRAVATQANLQTLQARGMLLWGPDSGSQAC
GDVGPGRMLDPLEIVELANSHFSAPQDLQHLKIMLTAGPTREALDPVRFISNHSSGKMGFAIARAAAARGAQVTLIAGPV
NLPTPPWVTRVDVVSALEMEQAVQQRAAAQDIFISCAAVADYRAEQISDEKIKKQGDEIILKMVKNPDIVAGVAAMTKKR
PFVVGFAAETQNVEEYARQKLARKKLDLICANDVSLAEHGFNSDTNALHLFWQDGEKRLALSDKALLGQRLIDEIVSRYD
EKNRR

Sequences:

>Translated_405_residues
MMTGLSGKHIVLGISGGIAAYKCPELVRRLRDRGAEVRVIMTSAAKAFITPLTLQAVSGHPVSDDLLDPAAEAAMGHIEL
GKWADLVILAPATADLLARVAAGMANDLLTTVCLATAAPIAAAPAMNQQMYRAVATQANLQTLQARGMLLWGPDSGSQAC
GDVGPGRMLDPLEIVELANSHFSAPQDLQHLKIMLTAGPTREALDPVRFISNHSSGKMGFAIARAAAARGAQVTLIAGPV
NLPTPPWVTRVDVVSALEMEQAVQQRAAAQDIFISCAAVADYRAEQISDEKIKKQGDEIILKMVKNPDIVAGVAAMTKKR
PFVVGFAAETQNVEEYARQKLARKKLDLICANDVSLAEHGFNSDTNALHLFWQDGEKRLALSDKALLGQRLIDEIVSRYD
EKNRR
>Mature_405_residues
MMTGLSGKHIVLGISGGIAAYKCPELVRRLRDRGAEVRVIMTSAAKAFITPLTLQAVSGHPVSDDLLDPAAEAAMGHIEL
GKWADLVILAPATADLLARVAAGMANDLLTTVCLATAAPIAAAPAMNQQMYRAVATQANLQTLQARGMLLWGPDSGSQAC
GDVGPGRMLDPLEIVELANSHFSAPQDLQHLKIMLTAGPTREALDPVRFISNHSSGKMGFAIARAAAARGAQVTLIAGPV
NLPTPPWVTRVDVVSALEMEQAVQQRAAAQDIFISCAAVADYRAEQISDEKIKKQGDEIILKMVKNPDIVAGVAAMTKKR
PFVVGFAAETQNVEEYARQKLARKKLDLICANDVSLAEHGFNSDTNALHLFWQDGEKRLALSDKALLGQRLIDEIVSRYD
EKNRR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=171, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=76.980198019802, Blast_Score=626, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17560194, Length=175, Percent_Identity=29.1428571428571, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322925, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=30.2702702702703, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43439; Mature: 43439

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTGLSGKHIVLGISGGIAAYKCPELVRRLRDRGAEVRVIMTSAAKAFITPLTLQAVSGH
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHEEEECCCC
PVSDDLLDPAAEAAMGHIELGKWADLVILAPATADLLARVAAGMANDLLTTVCLATAAPI
CCCHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AAAPAMNQQMYRAVATQANLQTLQARGMLLWGPDSGSQACGDVGPGRMLDPLEIVELANS
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
HFSAPQDLQHLKIMLTAGPTREALDPVRFISNHSSGKMGFAIARAAAARGAQVTLIAGPV
CCCCCHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCC
NLPTPPWVTRVDVVSALEMEQAVQQRAAAQDIFISCAAVADYRAEQISDEKIKKQGDEII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LKMVKNPDIVAGVAAMTKKRPFVVGFAAETQNVEEYARQKLARKKLDLICANDVSLAEHG
HHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEEECCCCHHHHCC
FNSDTNALHLFWQDGEKRLALSDKALLGQRLIDEIVSRYDEKNRR
CCCCCCEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMTGLSGKHIVLGISGGIAAYKCPELVRRLRDRGAEVRVIMTSAAKAFITPLTLQAVSGH
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHEEEECCCC
PVSDDLLDPAAEAAMGHIELGKWADLVILAPATADLLARVAAGMANDLLTTVCLATAAPI
CCCHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AAAPAMNQQMYRAVATQANLQTLQARGMLLWGPDSGSQACGDVGPGRMLDPLEIVELANS
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
HFSAPQDLQHLKIMLTAGPTREALDPVRFISNHSSGKMGFAIARAAAARGAQVTLIAGPV
CCCCCHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCC
NLPTPPWVTRVDVVSALEMEQAVQQRAAAQDIFISCAAVADYRAEQISDEKIKKQGDEII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LKMVKNPDIVAGVAAMTKKRPFVVGFAAETQNVEEYARQKLARKKLDLICANDVSLAEHG
HHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEEECCCCHHHHCC
FNSDTNALHLFWQDGEKRLALSDKALLGQRLIDEIVSRYDEKNRR
CCCCCCEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]