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The map label for this gene is cytR [H]

Identifier: 157373022

GI number: 157373022

Start: 5309965

End: 5310993

Strand: Direct

Name: cytR [H]

Synonym: Spro_4790

Alternate gene names: 157373022

Gene position: 5309965-5310993 (Clockwise)

Preceding gene: 157373021

Following gene: 157373023

Centisome position: 97.45

GC content: 56.56

Gene sequence:

>1029_bases
TTGGAACACAAGAAAGAATTATCCATGGCAACCATGAAAGACGTTGCCGAAATGGCGGGCGTTTCAACGGCAACCGTGTC
GCGTGCGCTGATGAACCCGGAAAAGGTGTCAACGCCGACGCGTCAGAAAGTGGAACAGGCCGTACTGGCCGTGGGCTATT
CTCCTCATGCCCTCTCTCGCAATATCAAGCGTAACGAATCCCGGACTATCCTGGTGATCGTCCCCGACATTTGCGATCCG
TTTTTCGCCGATGTGATCCAGGGGATCGAGCAAACCGCCGCACAACAGGGCTACCTGGTGCTGATTGGTGACTGTGCTCA
GCAAAACCAGCAGGAACGCACCTTCGTCAACCTGATCATTACCAAACAAATCGATGGCATGCTGCTGCTCGGCTCCAACC
TGCCGTTCGATGCCAGCAAGGAAGAGCAGCGTAACCTGCCGCCGATGGTGATGGCCAACGAGTTTGCTCCGGAGCTGGAA
CTGCCGACGGTGCACATCGATAACCTGACCGCCGCCTTCGAAGCCGTGCATTATTTACATCAGCTCGGCCACCAGCAAAT
CGCCTGTGTCGCCGGGCCGGAACAGATGCCGCTCAGCCATTATCGCCTGCAAGGTTACATTCAGGCGCTACGTCGTAATG
GCATTACCGTCGAAAGCAGCTATATTACCCGGGGTGATTTCACCTACGAGGCTGGCGCTCAGGCGCTGGCAACGTTGATG
GCACAGCCAAAACCGCCGACGGCAGTGTTCTGCCACAGTGATGTGATGGCCATTGGCGTGCTGTCGCAGGCGAAAAAGAT
GGGGCTGCGGGTACCGCAGGACCTTTCTATCATCGGCTTTGACGACATCAAACTGGCGCAGTATTGCGATCCACCGTTAA
CCACAGTGGCTCAACCGCGCTACCAGATTGGCCAGCAGGCCATGTTATTGCTGTTGGAGCAGCTACACGGGCAGACCGTG
GCAAGCGGCTCCCGGCTATTGGACAGTGAATTGATTATCAGAGGCAGCACCGCTGCCCCGAAACGCTAG

Upstream 100 bases:

>100_bases
CGCGGATGGCGCTAAATGATAACAACACCACCGCACGCCAGAATTTGTGAGCAAACTGAAGTCGTCGCGTTGGCATGGGG
CTAACGCAAGGAGAAAGGCG

Downstream 100 bases:

>100_bases
TCAAATATTTTAGGGTTCAGTAACATGACGGACTTATCCCCTCATCAGGACACAGCGGAATAATAGTGGCACAAAAAGAC
TATGTAAGCCGTGGGCGCGC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MEHKKELSMATMKDVAEMAGVSTATVSRALMNPEKVSTPTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDICDP
FFADVIQGIEQTAAQQGYLVLIGDCAQQNQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFEAVHYLHQLGHQQIACVAGPEQMPLSHYRLQGYIQALRRNGITVESSYITRGDFTYEAGAQALATLM
AQPKPPTAVFCHSDVMAIGVLSQAKKMGLRVPQDLSIIGFDDIKLAQYCDPPLTTVAQPRYQIGQQAMLLLLEQLHGQTV
ASGSRLLDSELIIRGSTAAPKR

Sequences:

>Translated_342_residues
MEHKKELSMATMKDVAEMAGVSTATVSRALMNPEKVSTPTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDICDP
FFADVIQGIEQTAAQQGYLVLIGDCAQQNQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFEAVHYLHQLGHQQIACVAGPEQMPLSHYRLQGYIQALRRNGITVESSYITRGDFTYEAGAQALATLM
AQPKPPTAVFCHSDVMAIGVLSQAKKMGLRVPQDLSIIGFDDIKLAQYCDPPLTTVAQPRYQIGQQAMLLLLEQLHGQTV
ASGSRLLDSELIIRGSTAAPKR
>Mature_342_residues
MEHKKELSMATMKDVAEMAGVSTATVSRALMNPEKVSTPTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDICDP
FFADVIQGIEQTAAQQGYLVLIGDCAQQNQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFEAVHYLHQLGHQQIACVAGPEQMPLSHYRLQGYIQALRRNGITVESSYITRGDFTYEAGAQALATLM
AQPKPPTAVFCHSDVMAIGVLSQAKKMGLRVPQDLSIIGFDDIKLAQYCDPPLTTVAQPRYQIGQQAMLLLLEQLHGQTV
ASGSRLLDSELIIRGSTAAPKR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=339, Percent_Identity=74.3362831858407, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=35.4354354354354, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790194, Length=332, Percent_Identity=34.9397590361446, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=31.8318318318318, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=34.2424242424242, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1789068, Length=338, Percent_Identity=31.3609467455621, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI48994940, Length=310, Percent_Identity=28.3870967741935, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786540, Length=337, Percent_Identity=29.3768545994065, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=27.5316455696203, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790715, Length=314, Percent_Identity=25.796178343949, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787906, Length=304, Percent_Identity=25, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789456, Length=339, Percent_Identity=26.8436578171091, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=23.9482200647249, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37560; Mature: 37560

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKKELSMATMKDVAEMAGVSTATVSRALMNPEKVSTPTRQKVEQAVLAVGYSPHALSR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCCCCCHHHHC
NIKRNESRTILVIVPDICDPFFADVIQGIEQTAAQQGYLVLIGDCAQQNQQERTFVNLII
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEEEE
TKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFEAVHYLH
EECCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHH
QLGHQQIACVAGPEQMPLSHYRLQGYIQALRRNGITVESSYITRGDFTYEAGAQALATLM
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECEEECCCCCHHHHHHHHHHHH
AQPKPPTAVFCHSDVMAIGVLSQAKKMGLRVPQDLSIIGFDDIKLAQYCDPPLTTVAQPR
CCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YQIGQQAMLLLLEQLHGQTVASGSRLLDSELIIRGSTAAPKR
HHHHHHHHHHHHHHHCCCHHHCCCHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MEHKKELSMATMKDVAEMAGVSTATVSRALMNPEKVSTPTRQKVEQAVLAVGYSPHALSR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCCCCCHHHHC
NIKRNESRTILVIVPDICDPFFADVIQGIEQTAAQQGYLVLIGDCAQQNQQERTFVNLII
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEEEE
TKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFEAVHYLH
EECCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHH
QLGHQQIACVAGPEQMPLSHYRLQGYIQALRRNGITVESSYITRGDFTYEAGAQALATLM
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECEEECCCCCHHHHHHHHHHHH
AQPKPPTAVFCHSDVMAIGVLSQAKKMGLRVPQDLSIIGFDDIKLAQYCDPPLTTVAQPR
CCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YQIGQQAMLLLLEQLHGQTVASGSRLLDSELIIRGSTAAPKR
HHHHHHHHHHHHHHHCCCHHHCCCHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]