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The map label for this gene is pgi

Identifier: 157372710

GI number: 157372710

Start: 4951937

End: 4953583

Strand: Reverse

Name: pgi

Synonym: Spro_4477

Alternate gene names: 157372710

Gene position: 4953583-4951937 (Counterclockwise)

Preceding gene: 157372716

Following gene: 157372708

Centisome position: 90.91

GC content: 55.25

Gene sequence:

>1647_bases
ATGAAAAATATCAATCCTAGTCAAACCGCTGCTTGGCAAGCCCTGCAGCAACATTTCGAACAGATGAAAGATGTACAGAT
CAGCGATCTGTTTGCTCAGGACAAAGAGCGTTTCTCCAAGTTCTCTGCCACCTTCAACGATCAGATGCTGGTGGACTACT
CTAAAAACCGCATTAGCGCGGAGACCCTGGAGAAGCTGCAGGCACTGGCGAAAGAAACCGATCTGCAAAGCGCGATCAAA
TCCATGTTTGCCGGTGAGAAAATCAACCGTACCGAAGACCGTGCGGTGCTGCACGTTGCCCTGCGCAACCGCAGCAATAC
CCCAATTATCGTGGACGGCAAAGACGTGATGCCGGAAGTGAACGCGGTGCTGGCCAAAATGAAACAGTTCTGCGACCGCG
TGATTGGCGGTGACTGGAAAGGTTACACCGGCAAAGCCATTACCGACGTGGTGAACATCGGTATCGGCGGTTCTGATCTC
GGCCCTTATATGGCGACCGAGGCGCTGCGCCCTTACAAAAACCACCTGAATATGCATTTTGTCTCCAACGTTGACGGCAC
CCATATCGCCGAAACGCTGCAGCCACTGAACCCGGAAACCACCCTGTTCCTGGTGGCGTCCAAAACCTTCACTACTCAGG
AAACCATGACCAACGCCCACAGCGCGCGCGACTGGTTCCTGAGCACTGCCGGTGACCAAAAACACGTGGCGAAACACTTT
GCTGCGTTGTCCACCAACGGCAAGGCGGTGGGCGGGTTCGGTATTGATACCGCCAACATGTTCGAATTTTGGGACTGGGT
CGGAGGTCGTTATTCCCTGTGGTCGGCGATTGGCCTGTCGATTGCTTTGTCGCTGGGCTTTGATAACTTCGAACAACTGC
TGAGTGGCGCGCATGCGATGGACCAACACTTCGCACAAACTCCGGCAGAGAAAAACCTGCCGGTGCTGCTGGCGCTGATC
GGCATCTGGTACAACAATTTCTTCGGTGCAGAAACCGAAGCTATCCTGCCTTACGACCAGTACATGCACCGTTTTGCTGC
TTACTTCCAGCAGGGTAACATGGAATCCAACGGTAAGTATGTCGATCGCAACGGCAACCCGGTGGATTACCAGACCGGCC
CAATCATCTGGGGCGAGCCAGGCACCAACGGTCAGCACGCGTTTTACCAGTTGATCCATCAGGGGACCAAACTGGTGCCT
TGCGACTTTATCGCACCGGCCATCAGCCACAACCCGCTGAGCGACCACCACGCCAAACTGCTGTCGAACTTCTTCGCACA
GACCGAAGCGCTGGCGTTCGGTAAATCGCTGGAAGTGGTAGAGGCCGAGTTTGCCGCACAGGGTAAAACGCCGGAAGAGG
TCAAGCACGTGGCGCCGTTCAAGGTGTTTGAAGGCAACCGCCCGACCAACTCCATCCTGCTGCGTGAGATCACCCCGTTT
AGCCTGGGCAGCCTGATTGCCCTGTATGAACACAAGATCTTCACCCAGGGCGCGATCCTGAACATCTTCACCTTCGACCA
ATGGGGCGTGGAGCTGGGCAAGCAGCTGGCAAACCGCATCCTGCCGGAACTGGCGGGTGACGAAGCGGTCAGCAGCCATG
ACAGTTCAACCAATGCGCTGATCAACCGCTTTAAAGAATGGCGTTAA

Upstream 100 bases:

>100_bases
CAGTTAGCGCCTATCGCAAGAAAAGAGATCATAATCACAGTCGAACAGGCTACAATCGGACAACCACGTCATCTTTATTC
TCAAGCCTAAGAGTGTTGCT

Downstream 100 bases:

>100_bases
TTACCGCCTGAATTGATGCCAATAAAAAACCCGCCGCGGCGGGTTTTTTTACATCTGAACGATTACAGATCGATTGGCAC
TTCGAAACTGATGCCTGCGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKNINPSQTAAWQALQQHFEQMKDVQISDLFAQDKERFSKFSATFNDQMLVDYSKNRISAETLEKLQALAKETDLQSAIK
SMFAGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLAKMKQFCDRVIGGDWKGYTGKAITDVVNIGIGGSDL
GPYMATEALRPYKNHLNMHFVSNVDGTHIAETLQPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSTAGDQKHVAKHF
AALSTNGKAVGGFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEQLLSGAHAMDQHFAQTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLVP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEVVEAEFAAQGKTPEEVKHVAPFKVFEGNRPTNSILLREITPF
SLGSLIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELAGDEAVSSHDSSTNALINRFKEWR

Sequences:

>Translated_548_residues
MKNINPSQTAAWQALQQHFEQMKDVQISDLFAQDKERFSKFSATFNDQMLVDYSKNRISAETLEKLQALAKETDLQSAIK
SMFAGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLAKMKQFCDRVIGGDWKGYTGKAITDVVNIGIGGSDL
GPYMATEALRPYKNHLNMHFVSNVDGTHIAETLQPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSTAGDQKHVAKHF
AALSTNGKAVGGFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEQLLSGAHAMDQHFAQTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLVP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEVVEAEFAAQGKTPEEVKHVAPFKVFEGNRPTNSILLREITPF
SLGSLIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELAGDEAVSSHDSSTNALINRFKEWR
>Mature_548_residues
MKNINPSQTAAWQALQQHFEQMKDVQISDLFAQDKERFSKFSATFNDQMLVDYSKNRISAETLEKLQALAKETDLQSAIK
SMFAGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLAKMKQFCDRVIGGDWKGYTGKAITDVVNIGIGGSDL
GPYMATEALRPYKNHLNMHFVSNVDGTHIAETLQPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSTAGDQKHVAKHF
AALSTNGKAVGGFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEQLLSGAHAMDQHFAQTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLVP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEVVEAEFAAQGKTPEEVKHVAPFKVFEGNRPTNSILLREITPF
SLGSLIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELAGDEAVSSHDSSTNALINRFKEWR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=544, Percent_Identity=65.625, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=544, Percent_Identity=61.2132352941177, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=548, Percent_Identity=87.043795620438, Blast_Score=1011, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=63.2727272727273, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=63.6697247706422, Blast_Score=724, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=58.8342440801457, Blast_Score=650, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=550, Percent_Identity=63.2727272727273, Blast_Score=719, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=550, Percent_Identity=63.2727272727273, Blast_Score=719, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=550, Percent_Identity=63.2727272727273, Blast_Score=719, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SERP5 (A8GKD1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480699.1
- ProteinModelPortal:   A8GKD1
- SMR:   A8GKD1
- STRING:   A8GKD1
- GeneID:   5602562
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4477
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BioCyc:   SPRO399741:SPRO_4477-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61019; Mature: 61019

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 386-386 ACT_SITE 514-514

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPSQTAAWQALQQHFEQMKDVQISDLFAQDKERFSKFSATFNDQMLVDYSKNRISA
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCH
ETLEKLQALAKETDLQSAIKSMFAGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLAKMKQFCDRVIGGDWKGYTGKAITDVVNIGIGGSDLGPYMATEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLQPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSTAGDQKHVAKHF
ECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNGKAVGGFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEQLLSGAHAM
HHHCCCCCEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
DQHFAQTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLVPCDFIAPAISHNPLSDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSLEVVEAEFAAQGKTPEEVKHVAPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGSLIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELAGDEAVSSHDSSTNAL
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHH
INRFKEWR
HHHHHCCC
>Mature Secondary Structure
MKNINPSQTAAWQALQQHFEQMKDVQISDLFAQDKERFSKFSATFNDQMLVDYSKNRISA
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCH
ETLEKLQALAKETDLQSAIKSMFAGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLAKMKQFCDRVIGGDWKGYTGKAITDVVNIGIGGSDLGPYMATEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLQPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSTAGDQKHVAKHF
ECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNGKAVGGFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEQLLSGAHAM
HHHCCCCCEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
DQHFAQTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLVPCDFIAPAISHNPLSDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSLEVVEAEFAAQGKTPEEVKHVAPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGSLIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELAGDEAVSSHDSSTNAL
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHH
INRFKEWR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA