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The map label for this gene is xapR [H]

Identifier: 157372489

GI number: 157372489

Start: 4718788

End: 4719660

Strand: Direct

Name: xapR [H]

Synonym: Spro_4256

Alternate gene names: 157372489

Gene position: 4718788-4719660 (Clockwise)

Preceding gene: 157372473

Following gene: 157372493

Centisome position: 86.6

GC content: 58.99

Gene sequence:

>873_bases
GTGGTAGCGGAGGAGATGAACTTCACCCAAGCGGCGCTGCGGCTGAATATTTCGCAGCCGCCGCTCAGCAAACATATTAA
AGAGTTGGAGAGCCAACTGGGCGTGGAGTTATTCAAGCGTACCACCCGATCGATGGCATTGACGCTGGCCGGTCGCACGC
TGTTTCACAATGTAGAAATGCTGCTCGATCAGGCCGGGCATGCGCTCAATCAGGTGCAGCAGTTGGGGCGCGGCGAGGCC
GGGCATATGGTGATCGGCATGGTCGGCACTTCGGTTTGGGGCGGGCTAATCCCGGCGTTGAAACGCTTTACCTGGCAAAC
GGCCAACGTCACCTGGGCGTTAAACGAACTGACACCCAGCCAGCAGATTGCTGCGCTGCAAAAGCGTCATATCGATATTG
GCGTCTGGCGCGAGGCAAAGGAGCAGGTATTGCCGGGGCTGGCGAGTCAGTTGCTGGCACGGGAGAATATTGCGCTGGTG
CTGCCGCAGGGCCACCCACTGGCTCAGGCGGAAAGCCTGCCGCTCGCCGCGCTGCGGCATGAAAAATTCATTGTCCTGCC
GCCGCACGAAGCCAGTTTGGGTCTCTATCTGCACAATTTGTGTCTGCAGCAGGGTTTCAAGCCGGATATTGCCTATCAGG
TCAACGAGCCGCAAACGCTGATGGCACTGGTGGCCGAAGGCTATGGCATCACGCTGCTGCCGGACAGTTACGGCCGTATT
CCCTGGCCCGGCGTGCGTTTTTGCCCGCTGCAGCAGGCGCCGTCAGCGGATCTTTACGCTATTTATCATGCCGACAGCGC
AACGCCGGTGGTGCAGGCGTTTCTTGAGATGCTGCGTACAGCTCCCCAGAACAAGTCTGTGCAACGAGCTTAA

Upstream 100 bases:

>100_bases
TATAAATTGGTAGCTCCAGGAGGCGATCATCAGCATCAAACAGCCCCAGCCACTGCCCGATCCCAGCCGGATTAACTTCC
GCCTGCTGCACTATTTCCGC

Downstream 100 bases:

>100_bases
AGCGCCGGCTGCACCATAAACTGGCCGGCGCTGCCGCGATCCGCCATCTCCAGCGTCTGGCTGTAGAACAGGAACGGGAA
ATGTTCCGAAGTGGACTGGT

Product: DNA-binding transcriptional activator XapR

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVAEEMNFTQAALRLNISQPPLSKHIKELESQLGVELFKRTTRSMALTLAGRTLFHNVEMLLDQAGHALNQVQQLGRGEA
GHMVIGMVGTSVWGGLIPALKRFTWQTANVTWALNELTPSQQIAALQKRHIDIGVWREAKEQVLPGLASQLLARENIALV
LPQGHPLAQAESLPLAALRHEKFIVLPPHEASLGLYLHNLCLQQGFKPDIAYQVNEPQTLMALVAEGYGITLLPDSYGRI
PWPGVRFCPLQQAPSADLYAIYHADSATPVVQAFLEMLRTAPQNKSVQRA

Sequences:

>Translated_290_residues
MVAEEMNFTQAALRLNISQPPLSKHIKELESQLGVELFKRTTRSMALTLAGRTLFHNVEMLLDQAGHALNQVQQLGRGEA
GHMVIGMVGTSVWGGLIPALKRFTWQTANVTWALNELTPSQQIAALQKRHIDIGVWREAKEQVLPGLASQLLARENIALV
LPQGHPLAQAESLPLAALRHEKFIVLPPHEASLGLYLHNLCLQQGFKPDIAYQVNEPQTLMALVAEGYGITLLPDSYGRI
PWPGVRFCPLQQAPSADLYAIYHADSATPVVQAFLEMLRTAPQNKSVQRA
>Mature_290_residues
MVAEEMNFTQAALRLNISQPPLSKHIKELESQLGVELFKRTTRSMALTLAGRTLFHNVEMLLDQAGHALNQVQQLGRGEA
GHMVIGMVGTSVWGGLIPALKRFTWQTANVTWALNELTPSQQIAALQKRHIDIGVWREAKEQVLPGLASQLLARENIALV
LPQGHPLAQAESLPLAALRHEKFIVLPPHEASLGLYLHNLCLQQGFKPDIAYQVNEPQTLMALVAEGYGITLLPDSYGRI
PWPGVRFCPLQQAPSADLYAIYHADSATPVVQAFLEMLRTAPQNKSVQRA

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=277, Percent_Identity=44.4043321299639, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1787879, Length=255, Percent_Identity=34.1176470588235, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788887, Length=280, Percent_Identity=28.2142857142857, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI157672245, Length=236, Percent_Identity=31.3559322033898, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790399, Length=238, Percent_Identity=30.2521008403361, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693105, Length=234, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787601, Length=283, Percent_Identity=27.208480565371, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=189, Percent_Identity=31.7460317460317, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788297, Length=234, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=238, Percent_Identity=27.3109243697479, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=26.7241379310345, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786401, Length=134, Percent_Identity=29.8507462686567, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32006; Mature: 32006

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAEEMNFTQAALRLNISQPPLSKHIKELESQLGVELFKRTTRSMALTLAGRTLFHNVEM
CCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLDQAGHALNQVQQLGRGEAGHMVIGMVGTSVWGGLIPALKRFTWQTANVTWALNELTPS
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCH
QQIAALQKRHIDIGVWREAKEQVLPGLASQLLARENIALVLPQGHPLAQAESLPLAALRH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHCCCCHHHHCC
EKFIVLPPHEASLGLYLHNLCLQQGFKPDIAYQVNEPQTLMALVAEGYGITLLPDSYGRI
CCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCEEECCCCCCCC
PWPGVRFCPLQQAPSADLYAIYHADSATPVVQAFLEMLRTAPQNKSVQRA
CCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVAEEMNFTQAALRLNISQPPLSKHIKELESQLGVELFKRTTRSMALTLAGRTLFHNVEM
CCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLDQAGHALNQVQQLGRGEAGHMVIGMVGTSVWGGLIPALKRFTWQTANVTWALNELTPS
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCH
QQIAALQKRHIDIGVWREAKEQVLPGLASQLLARENIALVLPQGHPLAQAESLPLAALRH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHCCCCHHHHCC
EKFIVLPPHEASLGLYLHNLCLQQGFKPDIAYQVNEPQTLMALVAEGYGITLLPDSYGRI
CCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCEEECCCCCCCC
PWPGVRFCPLQQAPSADLYAIYHADSATPVVQAFLEMLRTAPQNKSVQRA
CCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]