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The map label for this gene is aroP [H]

Identifier: 157372247

GI number: 157372247

Start: 4452867

End: 4454249

Strand: Direct

Name: aroP [H]

Synonym: Spro_4013

Alternate gene names: 157372247

Gene position: 4452867-4454249 (Clockwise)

Preceding gene: 157372240

Following gene: 157372248

Centisome position: 81.72

GC content: 57.27

Gene sequence:

>1383_bases
ATGGATGGTCAACAGCATGATGGCGACCAGCTGAAACGCGGGCTTAAAAACCGCCATATTCAGCTTATTGCACTAGGGGG
CGCTATTGGTACCGGGCTATTTCTCGGCATCGCGCAAACAATAAAGATGGCCGGCCCTTCGGTCATTCTCGGTTATGCCA
TTGGCGGCTTTATCGCATTTCTGATCATGCGCCAACTGGGTGAAATGGTGGTCGAAGAGCCGGTGGCCGGTTCCTTTAGC
CACTTCGCCTATAAATACTGGGGCAACTTCGCCGGCTTCGCTTCCGGCTGGAACTACTGGGTGCTGTACGTCCTGGTTGC
CATGGCGGAACTGACCGCGGTGGGGATCTATGTGCAGTACTGGTGGCCGGAGATCCCGACCTGGGTGTCGGCAGCCGTAT
TCTTCCTGGCGATTAATGCCATCAACCTGGCAAACGTGAAGGTGTATGGCGAGATGGAATTCTGGTTCGCCATCATCAAG
GTCGTGGCGATTATCGGCATGATCGTGTTCGGTGCCTACCTGCTGTTCAGCGGCATGGGCGGGCCGGAAGCCACAGTGAC
CAATCTGTGGGCGCAGGGCGGGTTCTTCCCGAACGGCGTCATGGGGCTGGTGATGGCGATGGCGGTGATCATGTTCTCGT
TCGGTGGGCTGGAGTTGGTGGGCATCACCGCGGCAGAAGCCGACAACCCGCAGAAAAGCATTCCCAAAGCGACCAACCAG
GTTATCTACCGCATCCTGCTGTTCTATATCGGTTCACTGACCATTCTGTTGTCGCTGTACCCGTGGGGTAAAGTGGTTGA
AGGCGGTAGCCCGTTCGTACTGATCTTCCACGCGCTGAACAGCAACCTGGTAGCAACGGTGCTGAACGTGGTGGTGTTGA
CCGCCGCGCTGTCGGTATACAACAGCTGCGTCTACTGCAACAGCCGCATGCTGTACGGCCTGGCAAAACAGGGCAACGGG
CCGAAAAGCCTGCTGAAAGTCGACGGTCGCGGCGTCCCTGTCATTGCGATTGCCGTTTCCGCCACCGCCACGGCGTTCTG
CGTACTGATTAACTACCTGATCCCCGGCCGTGCCTTCGAACTGCTGATGGCGTTGGTGGTGTCGGCACTGGTGATCAACT
GGGCGATGATCAGCCTGGCACATCTGAAGTTCCGCGCAGCCAAGAACCGCGAAGGTGTTGAACCGAAGTTCAAAGCCTTC
TGGTACCCGTTCAGCAACTATCTGTGCCTGGTGTTTATGGCCGCTATCCTGGTGATCATGTACCTGACGCCGGGGATCCA
AATCTCGGTGTTGCTGATCCCGGTTTGGGTCGCCATTTTAGGCATCGGCTATGCCATTAAACAGCGTAGCCAGCGTGCCG
TGAGCGCTACAGGCCGCGGGTAA

Upstream 100 bases:

>100_bases
TGGAATTAATAGATATAACGCCGTAAATAAAACAAAACACACATCGTAACCACTGCTTTACAGCATGTGAGTAATTCTGC
AACGACAGAGGGTTTGATTG

Downstream 100 bases:

>100_bases
CCAAGCCAAAAAACAAGGCCCGCAGTGCAAACTGTGGGCCTTTTTATTGCCGCTCTATTTTGCAAGCTGGCTCACAGTTT
CCCCGCCACGGTGGATTTGT

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDGQQHDGDQLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VVAIIGMIVFGAYLLFSGMGGPEATVTNLWAQGGFFPNGVMGLVMAMAVIMFSFGGLELVGITAAEADNPQKSIPKATNQ
VIYRILLFYIGSLTILLSLYPWGKVVEGGSPFVLIFHALNSNLVATVLNVVVLTAALSVYNSCVYCNSRMLYGLAKQGNG
PKSLLKVDGRGVPVIAIAVSATATAFCVLINYLIPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNREGVEPKFKAF
WYPFSNYLCLVFMAAILVIMYLTPGIQISVLLIPVWVAILGIGYAIKQRSQRAVSATGRG

Sequences:

>Translated_460_residues
MDGQQHDGDQLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VVAIIGMIVFGAYLLFSGMGGPEATVTNLWAQGGFFPNGVMGLVMAMAVIMFSFGGLELVGITAAEADNPQKSIPKATNQ
VIYRILLFYIGSLTILLSLYPWGKVVEGGSPFVLIFHALNSNLVATVLNVVVLTAALSVYNSCVYCNSRMLYGLAKQGNG
PKSLLKVDGRGVPVIAIAVSATATAFCVLINYLIPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNREGVEPKFKAF
WYPFSNYLCLVFMAAILVIMYLTPGIQISVLLIPVWVAILGIGYAIKQRSQRAVSATGRG
>Mature_460_residues
MDGQQHDGDQLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VVAIIGMIVFGAYLLFSGMGGPEATVTNLWAQGGFFPNGVMGLVMAMAVIMFSFGGLELVGITAAEADNPQKSIPKATNQ
VIYRILLFYIGSLTILLSLYPWGKVVEGGSPFVLIFHALNSNLVATVLNVVVLTAALSVYNSCVYCNSRMLYGLAKQGNG
PKSLLKVDGRGVPVIAIAVSATATAFCVLINYLIPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNREGVEPKFKAF
WYPFSNYLCLVFMAAILVIMYLTPGIQISVLLIPVWVAILGIGYAIKQRSQRAVSATGRG

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=332, Percent_Identity=24.0963855421687, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=76.5350877192982, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=64.1425389755011, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=45.0331125827815, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=41.7633410672854, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=38.5120350109409, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87081915, Length=401, Percent_Identity=37.6558603491272, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=35.9628770301624, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=34.4748858447489, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1788480, Length=429, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=26.5895953757225, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082023, Length=268, Percent_Identity=23.134328358209, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=379, Percent_Identity=24.2744063324538, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=289, Percent_Identity=25.9515570934256, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=448, Percent_Identity=35.2678571428571, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324061, Length=438, Percent_Identity=34.0182648401827, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=32.5112107623318, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=35.0490196078431, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=33.25, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=404, Percent_Identity=31.6831683168317, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=444, Percent_Identity=32.8828828828829, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=30.5418719211823, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=440, Percent_Identity=30, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=433, Percent_Identity=30.2540415704388, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=451, Percent_Identity=30.820399113082, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=415, Percent_Identity=29.6385542168675, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=440, Percent_Identity=27.9545454545455, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=29.5, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=28.7878787878788, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=29.1457286432161, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=406, Percent_Identity=28.0788177339901, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=25.2049180327869, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24666159, Length=286, Percent_Identity=24.1258741258741, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221512776, Length=342, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667468, Length=383, Percent_Identity=25.3263707571802, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668806, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356285, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668802, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49907; Mature: 49907

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGQQHDGDQLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVILGYAIGGFIAF
CCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGNFAGFASGWNYWVLYVLVAMAELTAVGIYVQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVVAIIGMIVFGAYLLFSGMG
ECCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPEATVTNLWAQGGFFPNGVMGLVMAMAVIMFSFGGLELVGITAAEADNPQKSIPKATNQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VIYRILLFYIGSLTILLSLYPWGKVVEGGSPFVLIFHALNSNLVATVLNVVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHH
NSCVYCNSRMLYGLAKQGNGPKSLLKVDGRGVPVIAIAVSATATAFCVLINYLIPGRAFE
HHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSALVINWAMISLAHLKFRAAKNREGVEPKFKAFWYPFSNYLCLVFMAAILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHH
YLTPGIQISVLLIPVWVAILGIGYAIKQRSQRAVSATGRG
HHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDGQQHDGDQLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVILGYAIGGFIAF
CCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGNFAGFASGWNYWVLYVLVAMAELTAVGIYVQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVVAIIGMIVFGAYLLFSGMG
ECCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPEATVTNLWAQGGFFPNGVMGLVMAMAVIMFSFGGLELVGITAAEADNPQKSIPKATNQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VIYRILLFYIGSLTILLSLYPWGKVVEGGSPFVLIFHALNSNLVATVLNVVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHH
NSCVYCNSRMLYGLAKQGNGPKSLLKVDGRGVPVIAIAVSATATAFCVLINYLIPGRAFE
HHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSALVINWAMISLAHLKFRAAKNREGVEPKFKAFWYPFSNYLCLVFMAAILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHH
YLTPGIQISVLLIPVWVAILGIGYAIKQRSQRAVSATGRG
HHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]