Click here to switch to the map view.

The map label for this gene is can [H]

Identifier: 157372231

GI number: 157372231

Start: 4432263

End: 4432919

Strand: Direct

Name: can [H]

Synonym: Spro_3997

Alternate gene names: 157372231

Gene position: 4432263-4432919 (Clockwise)

Preceding gene: 157372227

Following gene: 157372234

Centisome position: 81.34

GC content: 53.12

Gene sequence:

>657_bases
ATGAAAGAAATCGAAAAGCTTATCGCTAATAACCATACCTGGTCGGCTAACATCAGCAAGGAAGACCCGAACTTTTTTGA
ACGTTTGGCCCAGGCGCAGAAGCCTCGCTTTTTATGGATAGGTTGTTCAGACAGCCGCGTTCCCGCGGAAAGACTGACCG
GGCTGGAGCCGGGTGAACTCTTTGTTCACCGTAACGTGGCCAACCTGGTGATTCACACCGATTTAAACTGCCTGTCGGTG
GTGCAGTACGCCGTCGACGTTCTGGAAGTTGAGCATATTATTATTTGCGGACACCTGGGCTGTGGTGGCGTAGAAGCCGC
GGTTGAGAACCCTGAGCTGGGGCTGATCAACAACTGGCTGCTGCACATCCGTGACCTGTGGTACAAGCACAGTTCACTGT
TGGGTGAGCTGGAGCCAGAACAGCGCCTCGACGTACTCTGTGAAATCAACGTGATTGAGCAAGTCTATAACCTGGGCCAT
TCCACCATTATGCAGTCAGCGTGGAAACGCGGGCAGAAAGTGATGATTCACGGTTGGGTGTACGGGATCCAAGACGGACG
TCTGCGGGATCTGGAAGTTGCAGCCACCAGCCGGGAAAGCCTGGAAATGGGCTATCGCAAGGCGATGGCTACACTGCAGC
AGGATAAGGGTATTTAA

Upstream 100 bases:

>100_bases
TGGCTGAATACCCTCTAGCGTAGCTGTTCCGATTTCCAAACTGTGACGCTTGTCCTATATTACCCCAACGCAATCTGTCC
GTTACAGGTCTATAACCTCC

Downstream 100 bases:

>100_bases
TCCTGTCAGGGGCGCGGCAAACCGCGCCCACCGCATATTACTCGTCCAGCAGCACTACTTTGCCGACGTACGGCAAATGG
CGATAACGCTGAGCGTAATC

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKEIEKLIANNHTWSANISKEDPNFFERLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSV
VQYAVDVLEVEHIIICGHLGCGGVEAAVENPELGLINNWLLHIRDLWYKHSSLLGELEPEQRLDVLCEINVIEQVYNLGH
STIMQSAWKRGQKVMIHGWVYGIQDGRLRDLEVAATSRESLEMGYRKAMATLQQDKGI

Sequences:

>Translated_218_residues
MKEIEKLIANNHTWSANISKEDPNFFERLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSV
VQYAVDVLEVEHIIICGHLGCGGVEAAVENPELGLINNWLLHIRDLWYKHSSLLGELEPEQRLDVLCEINVIEQVYNLGH
STIMQSAWKRGQKVMIHGWVYGIQDGRLRDLEVAATSRESLEMGYRKAMATLQQDKGI
>Mature_218_residues
MKEIEKLIANNHTWSANISKEDPNFFERLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSV
VQYAVDVLEVEHIIICGHLGCGGVEAAVENPELGLINNWLLHIRDLWYKHSSLLGELEPEQRLDVLCEINVIEQVYNLGH
STIMQSAWKRGQKVMIHGWVYGIQDGRLRDLEVAATSRESLEMGYRKAMATLQQDKGI

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=213, Percent_Identity=81.2206572769953, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1786534, Length=203, Percent_Identity=32.0197044334975, Blast_Score=94, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324292, Length=199, Percent_Identity=29.1457286432161, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24736; Mature: 24736

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIEKLIANNHTWSANISKEDPNFFERLAQAQKPRFLWIGCSDSRVPAERLTGLEPGEL
CHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCCCE
FVHRNVANLVIHTDLNCLSVVQYAVDVLEVEHIIICGHLGCGGVEAAVENPELGLINNWL
EEECCCEEEEEECCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LHIRDLWYKHSSLLGELEPEQRLDVLCEINVIEQVYNLGHSTIMQSAWKRGQKVMIHGWV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
YGIQDGRLRDLEVAATSRESLEMGYRKAMATLQQDKGI
EEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEIEKLIANNHTWSANISKEDPNFFERLAQAQKPRFLWIGCSDSRVPAERLTGLEPGEL
CHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCCCE
FVHRNVANLVIHTDLNCLSVVQYAVDVLEVEHIIICGHLGCGGVEAAVENPELGLINNWL
EEECCCEEEEEECCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LHIRDLWYKHSSLLGELEPEQRLDVLCEINVIEQVYNLGHSTIMQSAWKRGQKVMIHGWV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
YGIQDGRLRDLEVAATSRESLEMGYRKAMATLQQDKGI
EEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]