Click here to switch to the map view.

The map label for this gene is dlgD [H]

Identifier: 157372167

GI number: 157372167

Start: 4357580

End: 4358578

Strand: Direct

Name: dlgD [H]

Synonym: Spro_3933

Alternate gene names: 157372167

Gene position: 4357580-4358578 (Clockwise)

Preceding gene: 157372166

Following gene: 157372168

Centisome position: 79.97

GC content: 58.96

Gene sequence:

>999_bases
ATGAGAGTGAGTTACACCGATCTAAAGCAGCAATTCAAACGCGTGCTATTGGCGCGGGGCGTGGCGGAAGGCACCGCCGA
TGACTGTGCCGGTATGTTCGCCGATACCTCCGCCAGCGGCGTTTACTCCCACGGCGTTAACCGTTTCCCACGTTTTATTC
AGCAGTTGGACGCTGGCGATATTGTGCCGGACGCCGAGCCCAGCAAGCTGCTGTCGCTGGGTGCAATTGAGCAATGGGAC
GCCCATCAAGGCATAGGTAATCTCACCGCCCGCAAGATGATGGATCGCGCCATGCAGTTAGCCGACGGCCACGGTATCGG
GCTGGTGGCGCTGCGTAATGCCAACCACTGGATGCGCGGCGGCGGCTACGGCTGGCAAGCGGCAGAGAAAGGCTATATCG
GCATTTGCTGGACCAACTCAGCAGCAGTGATGCCGCCCTGGGGAGCCAAAGAGTGCCGCATCGGCACCAATCCATTGATC
GTCGCGGTGCCGGGTAACCCAATCACCATGGTGGATATGTCGATGTCGATGTTCTCCTATGGCGCGTTGGAGCTGAACCG
GCTGGCGGGCAAAACCCTGCCAGTGGACGGCGGCTTTGACAACGACGGGCAATTGACGCGCGATCCGGCCACCATTGAAG
AGAACCGTCGCATTCTTCCGATGGGCTACTGGAAAGGATCGGCGCTGTCGGTAGTGCTGGATATGATTGCCACCCTGCTT
TCCGGCGGATCTTCAGTCGCGGAAGTCACCGAGGACAACAGTGACGAGTACGGCGTGTCACAGGTGTTTATCGCCATTGA
GATCGAACGCTTGATCGACGGTGCCACTCGCGATGCAAAACTGCAGCGCATCATGGACTACATCACCAGCGCCGAACGCG
ATAACCCGGAGGTGGCTATCCGCCTGCCGGGCCATAAATTCCCACGCATTCATGCAGAAAACATGCGTGACGGCATTCCG
GTGGATGAGCGCATCTGGGCGCGCATTCAGGCGCTGTAA

Upstream 100 bases:

>100_bases
TTCGTTTAACCGCAGGTATAGCATTTATTTGAAATGCAATTCCGCATATTGAAATACAAAGAACACAAAACAAACAAATA
CGCCGTAGCGGAGAATCAGG

Downstream 100 bases:

>100_bases
CAGGAGAAACACCATGATCTTTGGCCATATCGCCAATACCTCACCGGAGCACTACCCGGCACCGGTGGCTCACGCCATCG
CCTATTTGCAAGGCACGGAT

Product: 2,3-diketo-L-gulonate reductase

Products: NA

Alternate protein names: 2,3-DKG reductase; 3-dehydro-L-gulonate 2-dehydrogenase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRVSYTDLKQQFKRVLLARGVAEGTADDCAGMFADTSASGVYSHGVNRFPRFIQQLDAGDIVPDAEPSKLLSLGAIEQWD
AHQGIGNLTARKMMDRAMQLADGHGIGLVALRNANHWMRGGGYGWQAAEKGYIGICWTNSAAVMPPWGAKECRIGTNPLI
VAVPGNPITMVDMSMSMFSYGALELNRLAGKTLPVDGGFDNDGQLTRDPATIEENRRILPMGYWKGSALSVVLDMIATLL
SGGSSVAEVTEDNSDEYGVSQVFIAIEIERLIDGATRDAKLQRIMDYITSAERDNPEVAIRLPGHKFPRIHAENMRDGIP
VDERIWARIQAL

Sequences:

>Translated_332_residues
MRVSYTDLKQQFKRVLLARGVAEGTADDCAGMFADTSASGVYSHGVNRFPRFIQQLDAGDIVPDAEPSKLLSLGAIEQWD
AHQGIGNLTARKMMDRAMQLADGHGIGLVALRNANHWMRGGGYGWQAAEKGYIGICWTNSAAVMPPWGAKECRIGTNPLI
VAVPGNPITMVDMSMSMFSYGALELNRLAGKTLPVDGGFDNDGQLTRDPATIEENRRILPMGYWKGSALSVVLDMIATLL
SGGSSVAEVTEDNSDEYGVSQVFIAIEIERLIDGATRDAKLQRIMDYITSAERDNPEVAIRLPGHKFPRIHAENMRDGIP
VDERIWARIQAL
>Mature_332_residues
MRVSYTDLKQQFKRVLLARGVAEGTADDCAGMFADTSASGVYSHGVNRFPRFIQQLDAGDIVPDAEPSKLLSLGAIEQWD
AHQGIGNLTARKMMDRAMQLADGHGIGLVALRNANHWMRGGGYGWQAAEKGYIGICWTNSAAVMPPWGAKECRIGTNPLI
VAVPGNPITMVDMSMSMFSYGALELNRLAGKTLPVDGGFDNDGQLTRDPATIEENRRILPMGYWKGSALSVVLDMIATLL
SGGSSVAEVTEDNSDEYGVSQVFIAIEIERLIDGATRDAKLQRIMDYITSAERDNPEVAIRLPGHKFPRIHAENMRDGIP
VDERIWARIQAL

Specific function: Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790000, Length=332, Percent_Identity=75.6024096385542, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1787020, Length=334, Percent_Identity=23.9520958083832, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1786727, Length=273, Percent_Identity=26.3736263736264, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17507179, Length=311, Percent_Identity=26.0450160771704, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17536633, Length=312, Percent_Identity=24.3589743589744, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24667904, Length=269, Percent_Identity=28.996282527881, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45553211, Length=269, Percent_Identity=28.996282527881, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667912, Length=269, Percent_Identity=28.996282527881, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667908, Length=269, Percent_Identity=28.996282527881, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24658010, Length=282, Percent_Identity=27.3049645390071, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648360, Length=310, Percent_Identity=27.741935483871, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.130 [H]

Molecular weight: Translated: 36265; Mature: 36265

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSYTDLKQQFKRVLLARGVAEGTADDCAGMFADTSASGVYSHGVNRFPRFIQQLDAGD
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
IVPDAEPSKLLSLGAIEQWDAHQGIGNLTARKMMDRAMQLADGHGIGLVALRNANHWMRG
CCCCCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEECC
GGYGWQAAEKGYIGICWTNSAAVMPPWGAKECRIGTNPLIVAVPGNPITMVDMSMSMFSY
CCCCCCCCCCCEEEEEEECCCEECCCCCCCCCEECCCCEEEEECCCCEEEEEEHHHHHHH
GALELNRLAGKTLPVDGGFDNDGQLTRDPATIEENRRILPMGYWKGSALSVVLDMIATLL
CCHHHHHHCCCCCCCCCCCCCCCCEECCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHH
SGGSSVAEVTEDNSDEYGVSQVFIAIEIERLIDGATRDAKLQRIMDYITSAERDNPEVAI
CCCCCEEHHHCCCCCCCCCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEE
RLPGHKFPRIHAENMRDGIPVDERIWARIQAL
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRVSYTDLKQQFKRVLLARGVAEGTADDCAGMFADTSASGVYSHGVNRFPRFIQQLDAGD
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
IVPDAEPSKLLSLGAIEQWDAHQGIGNLTARKMMDRAMQLADGHGIGLVALRNANHWMRG
CCCCCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEECC
GGYGWQAAEKGYIGICWTNSAAVMPPWGAKECRIGTNPLIVAVPGNPITMVDMSMSMFSY
CCCCCCCCCCCEEEEEEECCCEECCCCCCCCCEECCCCEEEEECCCCEEEEEEHHHHHHH
GALELNRLAGKTLPVDGGFDNDGQLTRDPATIEENRRILPMGYWKGSALSVVLDMIATLL
CCHHHHHHCCCCCCCCCCCCCCCCEECCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHH
SGGSSVAEVTEDNSDEYGVSQVFIAIEIERLIDGATRDAKLQRIMDYITSAERDNPEVAI
CCCCCEEHHHCCCCCCCCCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEE
RLPGHKFPRIHAENMRDGIPVDERIWARIQAL
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA