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The map label for this gene is lysR [H]

Identifier: 157372072

GI number: 157372072

Start: 4247555

End: 4248478

Strand: Direct

Name: lysR [H]

Synonym: Spro_3837

Alternate gene names: 157372072

Gene position: 4247555-4248478 (Clockwise)

Preceding gene: 157372070

Following gene: 157372075

Centisome position: 77.95

GC content: 60.61

Gene sequence:

>924_bases
ATGCACGCGATAACGCTACGCCAGATTGAAATCTTCTATGCGGTGATGACCACCGGCAACCTGACCGAAGCCGCCGCGCT
GCTGCAAACCTCGCAGCCCACCGTCAGCCGCGAGCTGGCGCGCTTTGAGAAGCTAATCCAGCTGCAATTGTTCGAACGGG
TTCGCGGCCGGTTATCCCCAACGGTGCAAGGCCTGCGGCTATTGGAAGAGGTGCAGCGCTCCTACTACGGTCTGGATCGT
ATCACCGCCGCCGCCGCCAGTATCCGCCAGTTCCGGCAGGCGCAGCTGTCGATTGCCTGCCTGCCGGTGTTCTCGCAATC
ACTGCTACCCGCGGTGTGCAAACCTTTTATCGATCGCTATCCGGAAGTGAGTTTCAGCGTAATACCGCAGGAATCACCGC
TGCTGGAGGAGTGGCTGTCGGCGCAGCGTCACGATTTGGGACTCACAGAAAATACCCTGACCCCGGCGGGGACCGAGCGC
ATGACGCTGATGACCTTGAACGAGGTGTGCGTGCTACCGGCCGGGCATCCCCTGCTGGCGAAAACGGTGTTGACGCCGCA
GGACTTTGCCGGACAAAACTTTATCAGCCTGTCGAACACCGACAGCTATCGCCAGCTACTGGATTCGTTGTTCAGTGAGG
AAGGAGTCAACCGCCGTTTGGTGATGGAAACCCATAGCGCCGCATCGGTCTGCGCCATGGTTAAAGCGGGAGTGGGAGTG
TCGATCGTTAACCCGCTGACGGCGCTCGATTACGCCGGCAGCGGCGTCCACGTGCGGCCATTCAGCGTTGAGGTCCCCTT
TACCGTCAGTCTGATCCGGCCGCTGCATCGCCCATCGTCGGCGCTGGTCACGGCCTTTACTCAGCATTTGCAACAGCAGG
CGGAGACACTCCCCGCCCGCCTGGCTGCGGTAATTACACGCTAG

Upstream 100 bases:

>100_bases
AATACCCCAATATTGCCGCACGCTTTCTTGGATGGAAAATATCTATTTAGCCAGAGTCTATTCATTTATGATATGGCTTT
GCTGATTAAAAGAGCTGCCG

Downstream 100 bases:

>100_bases
CCGGGCGCTTGGCGCGGCTGAAGGTCACTATGCAGAGCAGCAGCCCCAGCAGCGCGATCCCCGCGGCCGCCAGCGGTACG
CTGGTCAAGCCCAGCCCCTG

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MHAITLRQIEIFYAVMTTGNLTEAAALLQTSQPTVSRELARFEKLIQLQLFERVRGRLSPTVQGLRLLEEVQRSYYGLDR
ITAAAASIRQFRQAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSFSVIPQESPLLEEWLSAQRHDLGLTENTLTPAGTER
MTLMTLNEVCVLPAGHPLLAKTVLTPQDFAGQNFISLSNTDSYRQLLDSLFSEEGVNRRLVMETHSAASVCAMVKAGVGV
SIVNPLTALDYAGSGVHVRPFSVEVPFTVSLIRPLHRPSSALVTAFTQHLQQQAETLPARLAAVITR

Sequences:

>Translated_307_residues
MHAITLRQIEIFYAVMTTGNLTEAAALLQTSQPTVSRELARFEKLIQLQLFERVRGRLSPTVQGLRLLEEVQRSYYGLDR
ITAAAASIRQFRQAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSFSVIPQESPLLEEWLSAQRHDLGLTENTLTPAGTER
MTLMTLNEVCVLPAGHPLLAKTVLTPQDFAGQNFISLSNTDSYRQLLDSLFSEEGVNRRLVMETHSAASVCAMVKAGVGV
SIVNPLTALDYAGSGVHVRPFSVEVPFTVSLIRPLHRPSSALVTAFTQHLQQQAETLPARLAAVITR
>Mature_307_residues
MHAITLRQIEIFYAVMTTGNLTEAAALLQTSQPTVSRELARFEKLIQLQLFERVRGRLSPTVQGLRLLEEVQRSYYGLDR
ITAAAASIRQFRQAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSFSVIPQESPLLEEWLSAQRHDLGLTENTLTPAGTER
MTLMTLNEVCVLPAGHPLLAKTVLTPQDFAGQNFISLSNTDSYRQLLDSLFSEEGVNRRLVMETHSAASVCAMVKAGVGV
SIVNPLTALDYAGSGVHVRPFSVEVPFTVSLIRPLHRPSSALVTAFTQHLQQQAETLPARLAAVITR

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=306, Percent_Identity=72.875816993464, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI145693105, Length=270, Percent_Identity=22.5925925925926, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788887, Length=267, Percent_Identity=25.8426966292135, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787530, Length=229, Percent_Identity=25.764192139738, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=22.707423580786, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788481, Length=248, Percent_Identity=27.8225806451613, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787879, Length=257, Percent_Identity=26.4591439688716, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33853; Mature: 33853

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAITLRQIEIFYAVMTTGNLTEAAALLQTSQPTVSRELARFEKLIQLQLFERVRGRLSP
CCCEEHHHHHHHHEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLLEEVQRSYYGLDRITAAAASIRQFRQAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEVSFSVIPQESPLLEEWLSAQRHDLGLTENTLTPAGTERMTLMTLNEVCVLPAGHPLLA
CCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHH
KTVLTPQDFAGQNFISLSNTDSYRQLLDSLFSEEGVNRRLVMETHSAASVCAMVKAGVGV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCE
SIVNPLTALDYAGSGVHVRPFSVEVPFTVSLIRPLHRPSSALVTAFTQHLQQQAETLPAR
EHHCHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LAAVITR
HHHHHCC
>Mature Secondary Structure
MHAITLRQIEIFYAVMTTGNLTEAAALLQTSQPTVSRELARFEKLIQLQLFERVRGRLSP
CCCEEHHHHHHHHEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLLEEVQRSYYGLDRITAAAASIRQFRQAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEVSFSVIPQESPLLEEWLSAQRHDLGLTENTLTPAGTERMTLMTLNEVCVLPAGHPLLA
CCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHH
KTVLTPQDFAGQNFISLSNTDSYRQLLDSLFSEEGVNRRLVMETHSAASVCAMVKAGVGV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCE
SIVNPLTALDYAGSGVHVRPFSVEVPFTVSLIRPLHRPSSALVTAFTQHLQQQAETLPAR
EHHCHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LAAVITR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]