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The map label for this gene is pepB

Identifier: 157371855

GI number: 157371855

Start: 4006419

End: 4007714

Strand: Reverse

Name: pepB

Synonym: Spro_3620

Alternate gene names: 157371855

Gene position: 4007714-4006419 (Counterclockwise)

Preceding gene: 157371856

Following gene: 157371854

Centisome position: 73.55

GC content: 58.56

Gene sequence:

>1296_bases
ATGACAACTGAATTTATGCTGGTAACGCTGTCGAACCAATCTGCTGACGCGCGCTGGGGCGAGAAAGCGCTGCTGAGCAC
CGGTGCAGAAGGGATGACCATCCACCTGACCGGCAAAGATAAACTGGGCAGCATTCAACGTGCGGCCCGTAAGATTGACG
GCCAGGGCATCAAGAATGTCAAACTGGCCGGTGACGGCTGGGATCTGGAAAACAGCTGGGCATTCTGGCAGGGCTTCCGT
GGGCCGAAAGGCAAACGCAGTGTCGAATGGGCACCATTGCCGGCAGCGGAAAGCAAAGAGCTGGAACAGCGCCTGAAGAT
TGTTGACTGGGTGCGTGACACCATCAACATGTCGGCGGAAGAGTTGGGGCCGGAGCAGTTGGCTACCCGCGCGGTTGATC
TGATGTGTGACATCGGTTGTGAAGCCGTCAGCTATCGTATTACCAAGGGTGAAGATCTGCGTGAGCAAAACTACGCCGGT
ATTCACACCGTGGGCCGTGGGTCAGATCGTTCACCGGTGCTGTTGGCACTGGATTTCAACCCGACCGGTAACCCGGAAGC
GCCGGTGTTTGCCTGCCTGGTGGGTAAAGGCATCACCTTTGACACCGGTGGCTACAGCCTGAAACAAAGCGCCTTTATGG
ACTCCATGAAGGCGGATATGGGCGGTGCAGCCACCATTACCGGCGCACTGGCGCTGGCAGCGGCTCGCGGTCTGAAACAG
CGCGTGAAACTTTACCTGTGCTGTGCCGACAACATGGTCAGCGGCAATGCTTTCAAATTGGGTGACATCATCCGTTACCG
CAACGGCAAAACCGTTGAGGTGATGAATACCGATGCGGAAGGGCGTCTGGTGCTGGCCGATGGCCTGATCGATGCGTCCG
CGCAGAACCCTCAGTTGATCATCGACTGCGCCACTCTGACCGGTGCGGCGAAAACGGCGGTGGGTAACGACTATCATGCG
CTGTTCAGCTTCGATGACGCCCTGGCGCAAGAGCTGCTGGCCAGTGCGGCGGCGGAGCAAGAGCCATTCTGGCGTCTGCC
GCTGGCTGAATTCCACCGCAGCCAACTGCCGTCCAACTTTGCCGAACTGAACAACGTAGCCGGTCCGGCCTACACGGCGG
GTGCCAGTACCGCGGCTGCCTTCCTGTCGCATTTTGTGACTAACTACCAGCAGGGCTGGCTGCACATTGACTGTTCCGCT
ACTTACCGTAAAGGTGCAGTAGATCAATGGTCCGCTGGCGCAACCGGTCTGGGGGTACGTGCCCTGGCCAACCTGCTGCT
GAGCAAAGCCAGGTAA

Upstream 100 bases:

>100_bases
GCCGCCTAGCTGCAACTTGAAACTCATAGGGTATACAATAAAAATCCCCAATAGATTTTGCGTGTGGCGTGAAAATGAAG
GGGAAATCCGGAGTAAGGCT

Downstream 100 bases:

>100_bases
TTGAATGCCCACCCCGGTGGGCGTTATACCCGTCATCTTTCAAGTTGCAGCGTTGTTACCTGCTTACAAGGCCCATCCAT
GGGCCTTGCCCTTTCAGGGC

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNVKLAGDGWDLENSWAFWQGFR
GPKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAEELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAG
IHTVGRGSDRSPVLLALDFNPTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQ
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLIIDCATLTGAAKTAVGNDYHA
LFSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNFAELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSA
TYRKGAVDQWSAGATGLGVRALANLLLSKAR

Sequences:

>Translated_431_residues
MTTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNVKLAGDGWDLENSWAFWQGFR
GPKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAEELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAG
IHTVGRGSDRSPVLLALDFNPTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQ
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLIIDCATLTGAAKTAVGNDYHA
LFSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNFAELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSA
TYRKGAVDQWSAGATGLGVRALANLLLSKAR
>Mature_430_residues
TTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNVKLAGDGWDLENSWAFWQGFRG
PKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAEELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAGI
HTVGRGSDRSPVLLALDFNPTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQR
VKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLIIDCATLTGAAKTAVGNDYHAL
FSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNFAELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSAT
YRKGAVDQWSAGATGLGVRALANLLLSKAR

Specific function: Probably plays an important role in intracellular peptide degradation

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=318, Percent_Identity=38.3647798742138, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=34.5794392523364, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI87082123, Length=424, Percent_Identity=76.4150943396226, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=320, Percent_Identity=38.125, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=309, Percent_Identity=33.0097087378641, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=141, Percent_Identity=35.4609929078014, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221379063, Length=345, Percent_Identity=32.463768115942, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221379062, Length=345, Percent_Identity=32.463768115942, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21357381, Length=345, Percent_Identity=32.463768115942, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355725, Length=342, Percent_Identity=28.0701754385965, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24661038, Length=331, Percent_Identity=28.0966767371601, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662227, Length=325, Percent_Identity=29.5384615384615, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161077148, Length=322, Percent_Identity=30.1242236024845, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130057, Length=322, Percent_Identity=30.1242236024845, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129969, Length=375, Percent_Identity=28, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355645, Length=342, Percent_Identity=27.4853801169591, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24662223, Length=342, Percent_Identity=27.4853801169591, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19922386, Length=307, Percent_Identity=28.3387622149837, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129963, Length=305, Percent_Identity=29.1803278688525, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646701, Length=165, Percent_Identity=32.1212121212121, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646703, Length=165, Percent_Identity=32.1212121212121, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358201, Length=165, Percent_Identity=32.1212121212121, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPB_SERP5 (A8GHX6)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479844.1
- ProteinModelPortal:   A8GHX6
- SMR:   A8GHX6
- STRING:   A8GHX6
- MEROPS:   M17.004
- GeneID:   5605944
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3620
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   MLQLDYN
- ProtClustDB:   PRK05015
- BioCyc:   SPRO399741:SPRO_3620-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00504
- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819
- PANTHER:   PTHR11963:SF3
- PIRSF:   PIRSF036388
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17

EC number: =3.4.11.23

Molecular weight: Translated: 46273; Mature: 46142

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 208-208 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNV
CCCEEEEEEECCCCCCCHHCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEE
KLAGDGWDLENSWAFWQGFRGPKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAE
EEECCCCCCCCCCHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
ELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAGIHTVGRGSDRSPVLLALDFN
HCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCEEEECCCCCCCCEEEEEECC
PTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQ
CCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLI
EEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEE
IDCATLTGAAKTAVGNDYHALFSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNF
EEEECCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCHHH
AELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSATYRKGAVDQWSAGATGLGVR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
ALANLLLSKAR
HHHHHHHHCCC
>Mature Secondary Structure 
TTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNV
CCEEEEEEECCCCCCCHHCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEE
KLAGDGWDLENSWAFWQGFRGPKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAE
EEECCCCCCCCCCHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
ELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAGIHTVGRGSDRSPVLLALDFN
HCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCEEEECCCCCCCCEEEEEECC
PTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQ
CCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLI
EEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEE
IDCATLTGAAKTAVGNDYHALFSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNF
EEEECCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCHHH
AELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSATYRKGAVDQWSAGATGLGVR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
ALANLLLSKAR
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA