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The map label for this gene is patB [H]

Identifier: 157371853

GI number: 157371853

Start: 4003542

End: 4004720

Strand: Direct

Name: patB [H]

Synonym: Spro_3618

Alternate gene names: 157371853

Gene position: 4003542-4004720 (Clockwise)

Preceding gene: 157371852

Following gene: 157371865

Centisome position: 73.47

GC content: 54.96

Gene sequence:

>1179_bases
GTGAAACAGACCGATTTTAACCAGATAGTTAACCGCCACAACACCGGCTCGGTGAAATGGGACTTTATCGACCGCTATCT
GCAACTCGATGAAACCGACCTTTTGCCGATGTGGGTCTCTGATTTTGACTTCCAGTGCCCGGCGGAAGTCCGGCAGGCAC
TGCATCAGCGGGTTGATCACGGCATATTTGGCTATAGCGAACGCGATGACGCATATTACCAGGCGGCGATCAATTGGTTC
TCAAGACGGCACAATCTGCCTTTGCAGCGCGAATGGTTCACCTCCGTTGAGGGGGTGGTGCCCGGCCTGGCGATGCTGAT
CCAACTGCTCAGCCAGCCTGGCGATCCGGTAGTGATCCAGGGACCATACTATGGATCTTTCGCCAAGATCATCACCATGA
ACGGCCGAGAAGTCCTCGAAAACCCGCTGAAGGAAAGCGCGCAGGGTTATCAATTTGATTTCGAGCATCTGGAAGCCTGT
TTTGAACAGCGGAAACCGCCGTTACTGCTGTTGTGTAATCCGCATAACCCCACCGGGCGATGCTGGACCCGCAGCGAACT
GACACAATTGATGACGCTATGCAGTCGTCATGGCGTGACGGTGATTTCCGATGAAATCTGGGCCGACCTGACGCTGCCCG
GCGAAACCTTTACCTCGGTGCTGCATCTGGATGAAGCCTGGCACGACCAGATGATTTCGGCGACCTCAGCCAGCAAGAGC
TTTGGTTTGTCGTCGCTGAGGATCTCAAATTTCCTGATCCCCAATGTTCGCACCCGCAATGCGTTTATCGAACGCCTTAA
TGCCCATGGGTTGGATGTCTTTAATGCGCTGTCGATGACTGCCGCAACGGCAGCTTATCAACAGGGGGAAGCCTGGCTTG
ATGATTTACAAGGTTATCTGGCCGACAACCGGCGTTGGTTTGAGCAGGCATTAGCCTGTGCCGCACCCTGGTGTAAAATG
ACCCCAGCCGAGGGAACCTACCTTGCCTGGCTGGATTGTCGCGCCTTAGGCCTGGATGATCACGCCCTACAGCAGGCGTT
GATCCACCAGTCGAAAATTGCCGCCTCGATGGGCATCAGCTTTGGCGAGCAGGGAAAAGGCTTTATTCGCATCAACCTCG
GCTGTCCTCGCCAATATCTTGAACAGGCCATCGCGGGGCTCGCCCGGTTAAAACCCTGA

Upstream 100 bases:

>100_bases
TGCTACGCCGCCGTGGTCTTCGCCCTGATTTATGGGTTTACCGGATTTGGGATTGCCAGAATACAGCCAGAAAACGATTT
ACAGCGTAAGGAAGCCTGAC

Downstream 100 bases:

>100_bases
ACCACAATCACCGACGTATGAAAGGCCCCAAACGGGGTCTTTTTGTTGAACGATATCTGGCGGAAATGGTTGAACGAATT
TACCTCGACCTGACGGTATA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKQTDFNQIVNRHNTGSVKWDFIDRYLQLDETDLLPMWVSDFDFQCPAEVRQALHQRVDHGIFGYSERDDAYYQAAINWF
SRRHNLPLQREWFTSVEGVVPGLAMLIQLLSQPGDPVVIQGPYYGSFAKIITMNGREVLENPLKESAQGYQFDFEHLEAC
FEQRKPPLLLLCNPHNPTGRCWTRSELTQLMTLCSRHGVTVISDEIWADLTLPGETFTSVLHLDEAWHDQMISATSASKS
FGLSSLRISNFLIPNVRTRNAFIERLNAHGLDVFNALSMTAATAAYQQGEAWLDDLQGYLADNRRWFEQALACAAPWCKM
TPAEGTYLAWLDCRALGLDDHALQQALIHQSKIAASMGISFGEQGKGFIRINLGCPRQYLEQAIAGLARLKP

Sequences:

>Translated_392_residues
MKQTDFNQIVNRHNTGSVKWDFIDRYLQLDETDLLPMWVSDFDFQCPAEVRQALHQRVDHGIFGYSERDDAYYQAAINWF
SRRHNLPLQREWFTSVEGVVPGLAMLIQLLSQPGDPVVIQGPYYGSFAKIITMNGREVLENPLKESAQGYQFDFEHLEAC
FEQRKPPLLLLCNPHNPTGRCWTRSELTQLMTLCSRHGVTVISDEIWADLTLPGETFTSVLHLDEAWHDQMISATSASKS
FGLSSLRISNFLIPNVRTRNAFIERLNAHGLDVFNALSMTAATAAYQQGEAWLDDLQGYLADNRRWFEQALACAAPWCKM
TPAEGTYLAWLDCRALGLDDHALQQALIHQSKIAASMGISFGEQGKGFIRINLGCPRQYLEQAIAGLARLKP
>Mature_392_residues
MKQTDFNQIVNRHNTGSVKWDFIDRYLQLDETDLLPMWVSDFDFQCPAEVRQALHQRVDHGIFGYSERDDAYYQAAINWF
SRRHNLPLQREWFTSVEGVVPGLAMLIQLLSQPGDPVVIQGPYYGSFAKIITMNGREVLENPLKESAQGYQFDFEHLEAC
FEQRKPPLLLLCNPHNPTGRCWTRSELTQLMTLCSRHGVTVISDEIWADLTLPGETFTSVLHLDEAWHDQMISATSASKS
FGLSSLRISNFLIPNVRTRNAFIERLNAHGLDVFNALSMTAATAAYQQGEAWLDDLQGYLADNRRWFEQALACAAPWCKM
TPAEGTYLAWLDCRALGLDDHALQQALIHQSKIAASMGISFGEQGKGFIRINLGCPRQYLEQAIAGLARLKP

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=166, Percent_Identity=27.1084337349398, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI56713254, Length=166, Percent_Identity=27.1084337349398, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=40.1028277634961, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788722, Length=362, Percent_Identity=24.8618784530387, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322401, Length=181, Percent_Identity=29.8342541436464, Blast_Score=83, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44401; Mature: 44401

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTDFNQIVNRHNTGSVKWDFIDRYLQLDETDLLPMWVSDFDFQCPAEVRQALHQRVDH
CCCCCHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHC
GIFGYSERDDAYYQAAINWFSRRHNLPLQREWFTSVEGVVPGLAMLIQLLSQPGDPVVIQ
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GPYYGSFAKIITMNGREVLENPLKESAQGYQFDFEHLEACFEQRKPPLLLLCNPHNPTGR
CCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
CWTRSELTQLMTLCSRHGVTVISDEIWADLTLPGETFTSVLHLDEAWHDQMISATSASKS
CCCHHHHHHHHHHHHHCCCEEEEHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHH
FGLSSLRISNFLIPNVRTRNAFIERLNAHGLDVFNALSMTAATAAYQQGEAWLDDLQGYL
CCCCHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ADNRRWFEQALACAAPWCKMTPAEGTYLAWLDCRALGLDDHALQQALIHQSKIAASMGIS
HCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
FGEQGKGFIRINLGCPRQYLEQAIAGLARLKP
CCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQTDFNQIVNRHNTGSVKWDFIDRYLQLDETDLLPMWVSDFDFQCPAEVRQALHQRVDH
CCCCCHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHC
GIFGYSERDDAYYQAAINWFSRRHNLPLQREWFTSVEGVVPGLAMLIQLLSQPGDPVVIQ
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GPYYGSFAKIITMNGREVLENPLKESAQGYQFDFEHLEACFEQRKPPLLLLCNPHNPTGR
CCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
CWTRSELTQLMTLCSRHGVTVISDEIWADLTLPGETFTSVLHLDEAWHDQMISATSASKS
CCCHHHHHHHHHHHHHCCCEEEEHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHH
FGLSSLRISNFLIPNVRTRNAFIERLNAHGLDVFNALSMTAATAAYQQGEAWLDDLQGYL
CCCCHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ADNRRWFEQALACAAPWCKMTPAEGTYLAWLDCRALGLDDHALQQALIHQSKIAASMGIS
HCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
FGEQGKGFIRINLGCPRQYLEQAIAGLARLKP
CCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]